scholarly journals Regulation of mitochondria function by natriuretic peptides

2019 ◽  
Vol 317 (5) ◽  
pp. F1164-F1168
Author(s):  
Mark Domondon ◽  
Anna B. Nikiforova ◽  
Kristine Y. DeLeon-Pennell ◽  
Daria V. Ilatovskaya
Keyword(s):  
Blood Pressure ◽  
Reactive Oxygen Species ◽  
Natriuretic Peptides ◽  
Mitochondrial Respiration ◽  
Reactive Oxygen Species Production ◽  
Current Knowledge ◽  
Fluid Retention ◽  
Oxygen Species ◽  
Species Production ◽  
The Relationship

Natriuretic peptides (NPs) are well known to promote renal Na+ excretion, counteracting the effects of the renin-angiotensin-aldosterone system. Thus, NPs serve as a key component in the maintenance of blood pressure, influencing fluid retention capabilities via osmoregulation. Recently, NPs have been shown to affect lipolysis and enhance lipid oxidation and mitochondrial respiration. Here, we provide an overview of current knowledge about the relationship between NPs and mitochondria-mediated processes such as reactive oxygen species production, Ca2+ signaling, and apoptosis. Establishing a clear physiological and mechanistic connection between NPs and mitochondria in the cardiovascular system will open new avenues of research aimed at understanding and potentially using it as a therapeutic target from a completely new angle.

scholarly journals The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Alexey Kondrashov ◽  
Stanislava Vranková ◽  
Ima Dovinová ◽  
Rudolf Ševčík ◽  
Jana Parohová ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Production ◽  
Spontaneously Hypertensive Rats ◽  
Red Wine ◽  
Oxygen Species ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Species Production

We aimed to perform a chemical analysis of both Alibernet red wine and an alcohol-free Alibernet red wine extract (AWE) and to investigate the effects of AWE on nitric oxide and reactive oxygen species production as well as blood pressure development in normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHRs). Total antioxidant capacity together with total phenolic and selected mineral content was measured in wine and AWE. Young 6-week-old male WKY and SHR were treated with AWE (24,2 mg/kg/day) for 3 weeks. Total NOS and SOD activities, eNOS and SOD1 protein expressions, and superoxide production were determined in the tissues. Both antioxidant capacity and phenolic content were significantly higher in AWE compared to wine. The AWE increased NOS activity in the left ventricle, aorta, and kidney of SHR, while it did not change NOS activity in WKY rats. Similarly, increased SOD activity in the plasma and left ventricle was observed in SHR only. There were no changes in eNOS and SOD1 expressions. In conclusion, phenolics and minerals included in AWE may contribute directly to increased NOS and SOD activities of SHR. Nevertheless, 3 weeks of AWE treatment failed to affect blood pressure of SHR.

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