Bone mineral density reference values in the normal female and male population of İzmir, Turkey

Abstract Background: While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults.Methods: We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ³ 21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO).Results: Peak lumbar spine BMD was 1.093±0.168g/cm2 in women, and 1.041±0.098g/cm2 for men. Peak whole-body BMD was 1.193±0.93g/cm2 in women at, and 1.224±0.112g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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Bone mineral density reference values in Singaporean adults and comparison for osteoporosis establishment – The Yishun Study

10.21203/rs.3.rs-37206/v4 ◽

2020 ◽

Author(s):

Kexun Chen ◽

Shiou-Liang Wee ◽

Benedict Wei Jun Pang ◽

Lay Khoon Lau ◽

Khalid Abdul Jabbar ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Reference Values ◽

World Health ◽

Whole Body ◽

Kappa Statistics ◽

Mineral Density ◽

Percentage Difference ◽

Prevalence Of Osteoporosis

Abstract Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ≥ 21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093±0.168g/cm2 in women, and 1.041±0.098g/cm2 for men. Peak whole-body BMD was 1.193±0.93g/cm2 in women at, and 1.224±0.112g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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Body composition and bone mineral density by Dual Energy X-ray Absorptiometry: Reference values for young children

Clinical Nutrition ◽

10.1016/j.clnu.2021.11.010 ◽

2021 ◽

Author(s):

Inge A.L.P. van Beijsterveldt ◽

Manouk van der Steen ◽

Kirsten S. de Fluiter ◽

Sander A.M.J. Spaans ◽

Anita C.S. Hokken-Koelega

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Young Children ◽

Bone Mineral ◽

Reference Values ◽

Dual Energy ◽

Mineral Density ◽

X Ray

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O0065 ESTABLISHING REFERENCE VALUES FOR BONE MINERAL DENSITY AND BODY COMPOSITION OF PRETERM NEONATES LESS THAN 2500 G USING DUAL-ENERGY X-RAY ABSORPTIOMETRY

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/00005176-200406001-00067 ◽

2004 ◽

Vol 39 (Supplement 1) ◽

pp. S32

Author(s):

S. C. Y. Ng ◽

Y. S. Lee ◽

S. L. Low ◽

P. L. Ooi

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Bone Mineral ◽

Reference Values ◽

Dual Energy ◽

Preterm Neonates ◽

Mineral Density ◽

X Ray

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Decision letter for "Genetic burden contributing to extremely low or high bone mineral density in a senior male population from the Osteoporotic Fractures in Men (MrOS) study"

10.1002/jbm4.10335/v2/decision1 ◽

2019 ◽

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Osteoporotic Fractures ◽

High Bone Mineral Density ◽

Mineral Density ◽

Male Population ◽

High Bone ◽

Genetic Burden

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Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment – The Yishun Study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-020-03646-y ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Kexun Kenneth Chen ◽

Shiou-Liang Wee ◽

Benedict Wei Jun Pang ◽

Lay Khoon Lau ◽

Khalid Abdul Jabbar ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Reference Values ◽

World Health ◽

Whole Body ◽

Kappa Statistics ◽

Mineral Density ◽

Percentage Difference ◽

Prevalence Of Osteoporosis

Abstract Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ≥21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093 ± 0.168 g/cm2 in women, and 1.041 ± 0.098 g/cm2 for men. Peak whole-body BMD was 1.193 ± 0.93 g/cm2 in women at, and 1.224 ± 0.112 g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5–163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

Download Full-text