Off-site evaluation of liver lesion detection by Gd-BOPTA-enhanced MR imaging

2001 ◽  
Vol 11 (2) ◽  
pp. 187-192 ◽  
Author(s):  
H.-B. Gehl ◽  
M. Bourne ◽  
L. Grazioli ◽  
A. Möller ◽  
K.-P. Lodemann
Keyword(s):  
Mr Imaging ◽  
Liver Lesion ◽  
Lesion Detection ◽  
Site Evaluation

MnDPDP-enhanced MR imaging of the liver

1997 ◽  
Vol 38 (5) ◽  
pp. 650-654 ◽  
Author(s):  
P. A. Kane ◽  
V. Ayton ◽  
H. L. Walters ◽  
I. Benjamin ◽  
N. D. Heaton ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Spin Echo ◽  
Surgical Excision ◽  
Liver Lesion ◽  
Hepatic Disease ◽  
Lesion Detection ◽  
Pathological Examination ◽  
Liver Tumours ◽  
Resected Liver ◽  
Primary Liver Tumours

Purpose: To compare lesion detection and characterisation predicted by MnDPDP-enhanced MR imaging with surgical excision and pathological examination. Material and Methods: Ninety patients were intravenously infused at a rate of 2 to 3 ml/min with 5 μmol/kg mangafodipir trisodium (MnDPDP, Teslascan). The patients were examined with spin-echo and gradient-echo T1-weighted MR imaging at 1 h and 24 h after the end of infusion. The results were compared with identical pre-contrast sequences. In 20 of these patients, the pre-operative MR findings were compared with intra-operative ultrasonography and histology of the resected liver specimens. Results: In those with liver metastases, there was a good correlation between MR and the hepatic disease in 11 out of 14 cases. In the group with primary liver tumours, MR findings correlated with hepatic disease in 5 out of 6 cases. Conclusion: Liver lesion characterisation is possible with MnDPDP, and MR contrast enhancement with this agent is considered to be an important adjunct to the radiological assessment of patients with neoplastic liver disease where accurate decisions for surgical planning are imperative.

Focal Liver Lesion Detection and Characterization with Diffusion-weighted MR Imaging: Comparison with Standard Breath-hold T2-weighted Imaging

Radiology ◽  
2008 ◽  
Vol 246 (3) ◽  
pp. 812-822 ◽  
Author(s):  
Tejas Parikh ◽  
Stephen J. Drew ◽  
Vivian S. Lee ◽  
Samson Wong ◽  
Elizabeth M. Hecht ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Liver Lesion ◽  
Focal Liver Lesion ◽  
Lesion Detection ◽  
Breath Hold ◽  
Diffusion Weighted

scholarly journals A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging

2021 ◽  
Vol 22 (9) ◽  
pp. 4586
Author(s):  
Marta Orts-Arroyo ◽  
Amadeo Ten-Esteve ◽  
Sonia Ginés-Cárdenas ◽  
Isabel Castro ◽  
Luis Martí-Bonmatí ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Lesion Detection ◽  
Resonance Imaging ◽  
X Ray Diffraction ◽  
Functional Images ◽  
High Relaxivity ◽  
Contrast Enhanced ◽  
Phantom Studies

The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging.

Dynamic breast MR imaging: is parametric mapping superior to image subtraction in lesion detection?

2007 ◽  
Vol 17 (12) ◽  
pp. 3093-3099 ◽  
Author(s):  
Kathinka D. Kurz ◽  
Hans-Jörg Wittsack ◽  
Reinhart Willers ◽  
Dirk Blondin ◽  
Ulrich Mödder ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Lesion Detection ◽  
Image Subtraction ◽  
Parametric Mapping ◽  
Breast Mr

Preoperative assessment of focal liver lesions: multidetector computed tomography challenges magnetic resonance imaging

2005 ◽  
Vol 46 (1) ◽  
pp. 9-15 ◽  
Author(s):  
K. Numminen ◽  
H. Isoniemi ◽  
J. Halavaara ◽  
P. Tervahartiala ◽  
H. Mäkisalo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Multidetector Computed Tomography ◽  
Intraoperative Ultrasound ◽  
Preoperative Assessment ◽  
Liver Lesion ◽  
Lesion Detection ◽  
Extrahepatic Disease ◽  
Focal Liver Lesions ◽  
Liver Lesions

Purpose: To investigate prospectively multidetector computed tomography (CT) (MDCT) and magnetic resonance (MR) imaging (MRI) in the preoperative assessment of focal liver lesions. Material and Methods: Multiphasic MDCT and conventional gadolinium‐enhanced MRI were performed on 31 consecutive patients prior to hepatic surgery. All images were blindly analyzed as consensus reading. Lesion counts and their relation to vascular structures and possible extrahepatic disease were determined. The data from the MDCT and MRI were compared with the results obtained by intraoperative ultrasound (IOUS) and palpation. Histopathologic verification was available. Results: At surgery, IOUS and palpation revealed 45 solid liver lesions. From these, preoperative MDCT detected 43 (96%) and MRI 35 (78%) deposits. MDCT performed statistically better than MRI in lesion detection ( P = 0.008). Assessment of lesion vascular proximity was correctly determined by MDCT in 98% of patients and by MRI in 87%. Statistical difference was found ( P = 0.002). IOUS and palpation changed the preoperative surgical plan as a result of extrahepatic disease in 8/31 (26%) cases. In MDCT as well in MRI extrahepatic involvement was suspected in two cases. Conclusion: MDCT was superior to MRI and nearly equal to IOUS in liver lesion detection and in the determination of lesion vascular proximity. However, both techniques fail to reliably detect extrahepatic disease.

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