Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy

2020 ◽  
Author(s):  
Hsin-Chih Yeh ◽  
Ching-Chia Li ◽  
Tsu-Ming Chien ◽  
Chia-Yang Li ◽  
Yen-Chen Cheng ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Urothelial Carcinoma ◽  
Body Mass ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Upper Tract ◽  
Interethnic Differences ◽  
The Impact

Impact of body mass index on the oncological outcomes of patients treated with radical nephroureterectomy for upper tract urothelial carcinoma

2017 ◽  
Vol 36 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Yohann Dabi ◽  
Mohammed El Mrini ◽  
Igor Duquesnes ◽  
Nicolas Barry Delongchamps ◽  
Mathilde Sibony ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Urothelial Carcinoma ◽  
Body Mass ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Upper Tract ◽  
Oncological Outcomes

scholarly journals Effect of Body Mass Index and Hypertension on the Prognosis of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy

2020 ◽  
Vol 18 (3) ◽  
pp. 201-208
Author(s):  
Minseung Lee ◽  
Sang Hun Song ◽  
Hakju Kim ◽  
Sangchul Lee ◽  
Sung Kyu Hong ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Urothelial Carcinoma ◽  
Body Mass ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Upper Tract

The Impact of Hospital Volume on Short-term and Long-term Outcomes for Patients Undergoing Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Urology ◽  
2021 ◽  
Vol 147 ◽  
pp. 135-142
Author(s):  
Wilson Sui ◽  
Christopher J.D. Wallis ◽  
Amy N. Luckenbaugh ◽  
Daniel A. Barocas ◽  
Sam S. Chang ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Hospital Volume ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Long Term Outcomes ◽  
Short Term ◽  
Upper Tract ◽  
The Impact

The Impact of Sex Differences on Renal Function Outcomes After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Retrospective Study

2021 ◽  
Author(s):  
Tsu-Ming Chien ◽  
Ching-Chia Li ◽  
Yen-Man Lu ◽  
Hsueh-Wei Chang ◽  
Yii-Her Chou ◽  
...  
Keyword(s):  
Renal Function ◽  
Sex Differences ◽  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Clinicopathological Parameters ◽  
Radical Nephroureterectomy ◽  
Upper Tract ◽  
Female Patients ◽  
Kaplan Meier ◽  
The Impact

Abstract Background: Upper tract urothelial carcinoma (UTUC) is a relatively rare type of urothelial carcinoma. Additionally, only few reports have examined the sex differences in patients with UTUC. Therefore, the present study aimed to identify the sex factors affecting renal function in patients with UTUC.Methods: Patients who underwent radical nephroureterectomy for non-metastatic UTUC between 2000 and 2013 were retrospectively reviewed and divided into two groups by sex. The Kaplan–Meier method was applied to evaluate the effects of sex on survival, whereas for the other clinicopathological parameters, hazard ratios were evaluated using the Cox regression model. The analyses were also performed in patients with different chronic kidney disease (CKD) stages.Results: A total of 368 patients were included, 147 men and 221 women. Female patients had a higher rate of anemia, advanced CKD stage, and dialysis. Male patients predominantly had a higher rate of smoking. The Kaplan–Meier analysis revealed no differences between sexes on metastasis-free survival (MFS) and cancer-specific survival. Multivariate analysis confirmed that ureteral tumors, advanced pathological tumor stage, and adjuvant chemotherapy indicated significantly worse survival outcomes in both sexes. However, only female patients with advanced CKD showed poorer MFS. After adjusting for renal function, the analysis found men had worse MFS.Conclusions: The female sex is significantly associated with a higher prevalence of advanced CKD among patients with UTUC in Taiwan. The impact of sex differences on renal function needs to be considered when evaluating survival.

scholarly journals Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zai-Lin Sheu ◽  
Chi-Ping Huang ◽  
Chao-Hsiang Chang ◽  
Chung-Hsin Chen ◽  
Jian-Hua Hong ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Free Survival ◽  
Upper Tract ◽  
Pelvic Tumors ◽  
Tumor Distribution ◽  
The Impact ◽  
Bladder Recurrence

AbstractTumor multifocality and location are prognostic factors for upper tract urothelial carcinoma (UTUC). However, confounding effects can appear when these two factors are analyzed together. Therefore, we aimed to investigate the impact of tumor distribution on the outcomes of multifocal UTUC after radical nephroureterectomy. From the 2780 UTUC patients in the Taiwan UTUC Collaboration Group, 685 UTUC cases with multifocal tumors (defined as more than one tumor lesion in unilateral upper urinary tract) were retrospectively included and divided into three groups: multiple renal pelvic tumors, multiple ureteral tumors, and synchronous renal pelvic and ureteral tumors included 164, 152, and 369 patients, respectively. We found the prevalence of carcinoma in situ was the highest in the synchronous group. In multivariate survival analyses, tumor distribution showed no difference in cancer-specific and disease-free survival, but there was a significant difference in bladder recurrence-free survival. The synchronous group had the highest bladder recurrence rate. In summary, tumor distribution did not influence the cancer-specific outcomes of multifocal UTUC, but synchronous lesions led to a higher rate of bladder recurrence than multiple renal pelvic tumors. We believe that the distribution of tumors reflects the degree of malignant involvement within the urinary tract, but has little significance for survival or disease progression.

scholarly journals Impact of Non-synchronous Diagnostic Ureteroscopy on Intravesical Recurrence in Patients Underwent Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Propensity-Score Matched Analysis

2019 ◽  
Author(s):  
Huamao Ye ◽  
Xiang Feng ◽  
Yang Wang ◽  
Rui Chen ◽  
Meimian Hua ◽  
...  
Keyword(s):  
Propensity Score ◽  
Regression Model ◽  
Urothelial Carcinoma ◽  
Cox Regression ◽  
Upper Tract Urothelial Carcinoma ◽  
Control Group ◽  
Radical Nephroureterectomy ◽  
Cox Regression Model ◽  
Upper Tract ◽  
The Impact

Abstract Background: The effect of diagnostic ureteroscopy (DURS) on intravesical recurrence (IVR) after radical nephroureterectomy (RNU) were controversial. To investigate the impact of DURS, we carried out this single-center retrospective study by applying propensity-score matching (PSM) and Cox regression model. Patients and Methods: The data of 160 patients with pTa-pT3 upper tract urothelial carcinoma (UTUC) were analyzed. Eighty-six patients underwent DURS (DURS group) and 74 patients without DURS (control group). The DURS group was further sub-grouped into synchronous DURS group (DURS followed by immediate RNU, n=45) and non-synchronous DURS group (DURS followed by delayed RNU, n=41). Baseline confounders were corrected by PSM. The impact of DURS on IVR was assessed by Kaplan-Meier analysis in PSM cohort and by Cox regression model in the full data set. Results: The median follow-up time was 40.4 months. No difference of the 3-year IVRFS between DURS group and control group (72.6% vs. 65.3%, p=0.263). In subgroup analysis, the 3-year IVR-free survival of non-synchronous DURS group (51.4%) was significantly lower than that of synchronous DURS (78.3%) or control group (72.6%) (p=0.027). Further Cox regression analysis showed that non-synchronous DURS (HR 1.481, 95% CI 1.031-2.127, p=0.034) was independent risk factors for postoperative IVR. Conclusions: Non-synchronous DURS was not recommended for the diagnosis and preoperative evaluation of UTUC, because it could raise the risk of IVR after RNU. For UTUC patients in need of DURS, synchronous DURS could be a safer choice than the non-synchronous DURS in terms of lowering the IVR risk.

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