Effects of aging on coronary flow reserve in patients with no evidence of myocardial perfusion abnormality

2020 ◽  
Vol 35 (12) ◽  
pp. 1633-1639
Author(s):  
Erasta Ramandika ◽  
Satoshi Kurisu ◽  
Kazuhiro Nitta ◽  
Takayuki Hidaka ◽  
Hiroto Utsunomiya ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Perfusion Abnormality ◽  
Flow Reserve ◽  
Myocardial Perfusion Abnormality ◽  
Effects Of Aging

Effects of aging on coronary flow reserve in patients with no evidence of myocardial perfusion abnormality

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
E Ramandika ◽  
S Kurisu ◽  
K Nitta ◽  
T Hidaka ◽  
H Utsunomiya ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Flow Velocity ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Perfusion Abnormality ◽  
Coronary Flow Velocity ◽  
Group Iii ◽  
Flow Reserve ◽  
Group I ◽  
Myocardial Perfusion Abnormality

Abstract Background Coronary flow reserve (CFR) reflects the functional capacity of microcirculation to adapt to blood demand during increased cardiac work. Purpose We tested the hypothesis that aging had impacts on coronary flow velocities and CFR in patients with no evidence of myocardial perfusion abnormality on single photon emission computed tomography (SPECT). Methods and results Seventy-six patients with no evidence of myocardial perfusion abnormality on SPECT undergoing transthoracic Doppler echocardiography were enrolled in this study. Patients were divided into three age groups: 17 patients aged <70 years (Group I), 38 patients aged 70–79 years (Group II), and 21 patients aged ≥80 years (Group III). Compared with Group I, CFR was significantly lower in Group II (P<0.01) and Group III (P<0.01). Multivariate analysis showed that female (P=0.03), cigarette smoking (P=0.004), hemoglobin level (P=0.001) and LV mass index (P=0.03) were determinants for resting coronary flow velocity. On the other hand, age (P=0.008), hemoglobin level (P<0.001) and LV mass index (P=0.04) were determinants for hyperemic coronary flow velocity. Age was only independent determinant for CFR (β=−0.48 P<0.001). Conclusions Our data suggested that aging impaired CFR in patients with no evidence of myocardial perfusion abnormality primarily due to the decrease in hyperemic coronary flow velocity. Comparison of coronary flow reserve amon Funding Acknowledgement Type of funding source: None

Comparison between regional myocardial perfusion reserve and coronary flow reserve in the canine heart

1995 ◽  
Vol 16 (12) ◽  
pp. 1860-1871 ◽  
Author(s):  
M. J. A. GELDOF ◽  
M. J. SCHALU ◽  
V. MANGER CATS ◽  
P. M. J. VAN DER ZWET ◽  
P. STEENDUK ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Myocardial Perfusion Reserve ◽  
Canine Heart ◽  
Regional Myocardial Perfusion ◽  
Perfusion Reserve ◽  
Flow Reserve

scholarly journals Fractional Flow Reserve or Coronary Flow Reserve for the Assessment of Myocardial Perfusion

2018 ◽  
Vol 20 (9) ◽  
Author(s):  
Valérie E. Stegehuis ◽  
Gilbert W. Wijntjens ◽  
Jan J. Piek ◽  
Tim P. van de Hoef
Keyword(s):  
Myocardial Perfusion ◽  
Coronary Flow Reserve ◽  
Fractional Flow Reserve ◽  
Coronary Flow ◽  
Fractional Flow ◽  
Flow Reserve

Myocardial perfusion imaging with first-pass computed tomographic imaging: Measurement of coronary flow reserve in an animal model of regional hyperemia

2010 ◽  
Vol 17 (4) ◽  
pp. 625-630 ◽  
Author(s):  
Timothy F. Christian ◽  
Mei Lee Frankish ◽  
Jennifer H. Sisemoore ◽  
Madeline R. Christian ◽  
George Gentchos ◽  
...  
Keyword(s):  
Animal Model ◽  
Myocardial Perfusion Imaging ◽  
Myocardial Perfusion ◽  
Coronary Flow Reserve ◽  
Perfusion Imaging ◽  
Coronary Flow ◽  
Tomographic Imaging ◽  
Computed Tomographic ◽  
Flow Reserve ◽  
First Pass
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