Radiation-induced tumors of the central nervous system occurring in childhood and adolescence

Abstract A cerebellar glioblastoma multiforme was diagnosed in a 22-year-old woman. This originated in the zone adjacent to a field irradiated 14 years earlier after the removal of a noncontiguous astrocytoma of the spinal cord. The accepted criteria for radiation-induced tumors of the central nervous system are discussed.

Download Full-text

Radiation-associated Gliomas: A Report of Four Cases and Analysis of Postradiation Tumors of the Central Nervous System

Neurosurgery ◽

10.1227/00006123-198509000-00007 ◽

1985 ◽

Vol 17 (3) ◽

pp. 436-445 ◽

Cited By ~ 112

Author(s):

Boleslaw H. Liwnicz ◽

Thomas S. Berger ◽

Regina G. Liwnicz ◽

Bernard S. Aron

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Latency Period ◽

White Men ◽

Anaplastic Ependymoma ◽

Primary Tumors ◽

Secondary Tumors ◽

Induced Tumors ◽

Radiation Induced ◽

The Central Nervous System

Abstract Four cases of radiation-associated gliomas are described. All patients were white men, irradiated in childhood for craniopharyngioma, anaplastic ependymoma, retinoblastoma of the orbit, and Burkitt's lymphoma, respectively. The dose ranged from 1800 to 5900 rads, and the latency period was 5 to 25 years. All primary and secondary tumors were verified histologically, and no evidence of persistence of the primary tumors was found. All secondary tumors arose in the fields of irradiation. Ninety-six cases of radiation-induced tumors of the central nervous system have been reported in the literature to date. Twenty-four were gliomas and occurred mainly in young men.

Download Full-text

Attempt to Modify the Ionizing Radiation Induced Histopathologic Effects on the Central Nervous System by Reserpine Administration

Acta Radiologica Therapy Physics Biology ◽

10.3109/02841867209130757 ◽

1972 ◽

Vol 11 (4) ◽

pp. 341-348

Author(s):

N. I. Harirî ◽

Y. Aksu ◽

S. Falakali ◽

O. I. Tuncer

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Ionizing Radiation ◽

Radiation Induced ◽

The Central Nervous System

Download Full-text

Amount of Satellite DNA in Four Experimentally Induced Tumors of the Central Nervous System. Quantitative Changes in a Glioblastoma Producing C-Type Particles 2

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/56.1.43 ◽

1976 ◽

Vol 56 (1) ◽

pp. 43-50 ◽

Cited By ~ 8

Author(s):

Laura Manuelidis ◽

Elias E. Manuelidis

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Satellite Dna ◽

Induced Tumors ◽

The Central Nervous System ◽

Quantitative Changes ◽

Experimentally Induced

Download Full-text

Involvement of the central nervous system in radiation-induced multi-organ dysfunction and/or failure

British Journal of Radiology ◽

10.1259/bjr/15393845 ◽

2005 ◽

Vol Supplement_27 (1) ◽

pp. 62-68 ◽

Cited By ~ 29

Author(s):

P Gourmelon ◽

C Marquette ◽

D Agay ◽

J Mathieu ◽

D Clarençon

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Organ Dysfunction ◽

Radiation Induced ◽

The Central Nervous System

Download Full-text

PRENOSOLOGICAL NEURO-PSYCHIATRIC DISORDERS AMONG SCHOOLCHILDREN AND THEIR RELATIONSHIP TO ENVIRONMENTAL FACTORS

Annals of the Russian academy of medical sciences ◽

10.15690/vramn.v67i7.337 ◽

2012 ◽

Vol 67 (7) ◽

pp. 30-34

Author(s):

I. G. Zorina

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Environmental Factors ◽

School Health ◽

Childhood And Adolescence ◽

Urogenital System ◽

The Status ◽

The Central Nervous System ◽

Cardio Vascular ◽

The City

Environmental factor is one of the most accurate indicators of determining the health of the population, especially in childhood and adolescence. A significant increase in the amount of data on the status of school health and the environment are the most precise and correct, in view of causation, to evaluate an individual's health at prenosological level in the presence of a specialized database of automated systems. The aim of our study ― the study of fundamental interactions and patterns of environmental factors in general and neuropsychiatric disease in schoolchildren of the city of Chelyabinsk. Revealed that among the multi-pollutant air Chelyabinsk first and second rank positions are occupied by selectively harmful to the central nervous system (lead, arsenic, manganese), or have complex adverse effects on the central nervous system, combined with damaging effects on the respiratory and cardio- vascular, urogenital system and blood forming organs, involving the immune mechanism (chromium compounds, lead, arsenic, carbon monoxide and manganese).

Download Full-text

Faculty Opinions recommendation of Favorable outcomes of pediatric patients treated with radiotherapy to the central nervous system who develop radiation-induced meningiomas.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9091973.9671073 ◽

2011 ◽

Author(s):

Sarah Donaldson ◽

Michael Olson

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Pediatric Patients ◽

Radiation Induced ◽

The Central Nervous System

Download Full-text

Environmental Causes of Central Nervous System Maldevelopment

PEDIATRICS ◽

10.1542/peds.113.s3.1076 ◽

2004 ◽

Vol 113 (Supplement_3) ◽

pp. 1076-1083

Author(s):

Patricia M. Rodier

Keyword(s):

Central Nervous System ◽

Nervous System ◽

New Drugs ◽

Postnatal Life ◽

Childhood And Adolescence ◽

The Public ◽

Toxic Agents ◽

Neurotransmitter Activity ◽

The Central Nervous System ◽

Environmental Causes

The central nervous system is the most vulnerable of all body systems to developmental injury. This review focuses on developmental processes by which the nervous system is formed and how those processes are known or suspected to be injured by toxic agents. The processes discussed are establishment of neuron numbers; migration of neurons; establishment of connections, neurotransmitter activity, and receptor numbers; deposition of myelin; and 2 processes that are prominent in postnatal development, trimming back of connections and postnatal neurogenesis. Our knowledge of the risks of exposure to environmental hazards in childhood and adolescence is minimal. Most of our information concerns the effects of neurotoxicants in prenatal and early postnatal life. More worrisome than our lack of data regarding later stages of development is the minimal effort that we have mounted to protect the public from known neurotoxic agents and that regulations for testing new drugs and chemicals still do not require any assessment of neuroteratologic effects.

Download Full-text