Effects of a formula with a probiotic Bifidobacterium lactis Supplement on the gut microbiota of low birth weight infants

2019 ◽  
Vol 59 (4) ◽  
pp. 1493-1503 ◽  
Author(s):  
Cheng Chi ◽  
Yong Xue ◽  
Ruixia Liu ◽  
Yanxin Wang ◽  
Na Lv ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gut Microbiota ◽  
Low Birth Weight Infants ◽  
Bifidobacterium Lactis

scholarly journals Optimisation of 16S rRNA gut microbiota profiling of extremely low birth weight infants

BMC Genomics ◽  
2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Cristina Alcon-Giner ◽  
Shabhonam Caim ◽  
Suparna Mitra ◽  
Jennifer Ketskemety ◽  
Udo Wegmann ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
16S Rrna ◽  
Gut Microbiota ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants

scholarly journals Beneficial Effects of Probiotic Treatment on Gut Microbiota in Very Low Birth Weight Infants

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Yue-feng Li ◽  
Chuan-rui Zhu ◽  
Xue-lei Gong ◽  
Hui-ling Li ◽  
Li-kuan Xiong ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gut Microbiota ◽  
Very Low Birth Weight ◽  
Secondary Outcome ◽  
Rrna Gene ◽  
Low Birth Weight Infants ◽  
Microbial Composition ◽  
Vlbw Infants ◽  
Probiotic Treatment

The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. Finally, 32 fecal specimens extracted from 16 preterm VLBW infants were qualified and analyzed using 16S rRNA gene sequencing. The primary outcome was to evaluate the change of gut microbiota in VLBW infants after combined probiotic supplement. The secondary outcome was to analyze the correlation gut microbial composition and levels of cytokines. We found that probiotic treatment, but not placebo, decreased the α-diversity of gut microbiota in VLBW infants. At the phylum level, probiotic treatment strongly increased the abundance of Firmicutes, whereas that of Proteobacteria was significantly reduced. At the family level, Streptococcaceae and Lactobacillaceae became prevalent after probiotic treatment, while the relative abundance of Enterobacteriaceae was reduced in the meantime. Most notably, significant correlations were observed between Lactobacillaceae abundance and serum cytokine levels. Further studies are required to shed more light on the characteristics of gut microbiota of VLBW neonates. And the modulation of microbiota should be considered to improve the survival rate of VLBW infants.

scholarly journals Colonization of Supplemented Bifidobacterium breve M-16V in Low Birth Weight Infants and Its Effects on Their Gut Microbiota Weeks Post-administration

2021 ◽  
Vol 12 ◽  
Author(s):  
Ayako Horigome ◽  
Ken Hisata ◽  
Toshitaka Odamaki ◽  
Noriyuki Iwabuchi ◽  
Jin-zhong Xiao ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gut Microbiota ◽  
16S Rrna Gene Sequencing ◽  
Fecal Microbiota ◽  
Control Group ◽  
Rrna Gene ◽  
Low Birth Weight Infants ◽  
Fecal Samples ◽  
Bifidobacterium Breve

The colonization and persistence of probiotics introduced into the adult human gut appears to be limited. It is uncertain, however, whether probiotics can successfully colonize the intestinal tracts of full-term and premature infants. In this study, we investigated the colonization and the effect of oral supplementation with Bifidobacterium breve M-16V on the gut microbiota of low birth weight (LBW) infants. A total of 22 LBW infants (12 infants in the M-16V group and 10 infants in the control group) were enrolled. B. breve M-16V was administrated to LBW infants in the M-16V group from birth until hospital discharge. Fecal samples were collected from each subject at weeks (3.7–9.3 weeks in the M-16V group and 2.1–6.1 weeks in the control group) after discharge. qPCR analysis showed that the administrated strain was detected in 83.3% of fecal samples in the M-16V group (at log10 8.33 ± 0.99 cell numbers per gram of wet feces), suggesting that this strain colonized most of the infants beyond several weeks post-administration. Fecal microbiota analysis by 16S rRNA gene sequencing showed that the abundance of Actinobacteria was significantly higher (P < 0.01), whereas that of Proteobacteria was significantly lower (P < 0.001) in the M-16V group as compared with the control group. Notably, the levels of the administrated strain and indigenous Bifidobacterium bacteria were both significantly higher in the M-16V group than in the control group. Our findings suggest that oral administration of B. breve M-16V led to engraftment for at least several weeks post-administration and we observed a potential overall improvement in microbiota formation in the LBW infants’ guts.

scholarly journals The development of gut microbiota in critically ill extremely low birth weight infants assessed with 16S rRNA gene based sequencing

Gut Microbes ◽  
2014 ◽  
Vol 5 (3) ◽  
pp. 304-503 ◽  
Author(s):  
Tiina Drell ◽  
Irja Lutsar ◽  
Jelena Štšepetova ◽  
Ülle Parm ◽  
Tuuli Metsvaht ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
16S Rrna ◽  
Gut Microbiota ◽  
16S Rrna Gene ◽  
Critically Ill ◽  
Extremely Low Birth Weight ◽  
Rrna Gene ◽  
Low Birth Weight Infants
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