Macro- and microcirculatory assessment of cold sensitivity after traumatic finger amputation and microsurgical replantation

2007 ◽  
Vol 127 (5) ◽  
pp. 355-360 ◽  
Author(s):  
Peter Klein-Weigel ◽  
Michaela Pavelka ◽  
Jörg Dabernig ◽  
Patrik Rein ◽  
Florian Kronenberg ◽  
...  
Keyword(s):  
Cold Sensitivity ◽  
Finger Amputation

Cytokine analysis in patients with different stages of thromboangiitis obliterans

2020 ◽  
Vol 20 ◽  
Author(s):  
Abbas Shapouri-Moghaddam ◽  
Seyed Jalil Tavakkol Afshari ◽  
Mohammad-Hadi Saeed Modaghegh ◽  
Hamid Reza Rahimi ◽  
Mahmoud Mahmoudi ◽  
...  
Keyword(s):  
Transforming Growth Factor ◽  
Vascular Diseases ◽  
Transforming Growth Factor Β ◽  
Serum Levels ◽  
Interferon Γ ◽  
Analysis Of Covariance ◽  
Cold Sensitivity ◽  
Thromboangiitis Obliterans ◽  
Burning Pain ◽  
Cytokine Analysis

Background: Studies suggest that cytokines are involved in the development of both inflammatory disorders and vascular diseases. Objective: The changes in transforming growth factor β (TGFβ), interleukin 6 (IL6), tumor necrosis factor α (TNFα), and interferon γ (IFNγ) with the progression of the thromboangiitis obliterans (TAO) symptomswereinvestigated in this research. Methods: This study included 80 patients with TAO, who were selected from the Vascular and Endovascular Research Center in Alavi Hospital between 2012 and 2016. They were then categorized into three groups: mild (migratory thrombophlebitis, cold sensitivity or Raynaud's phenomenon, and skin discoloration), moderate (chronic ulcers, claudication, and burning pain of the feet at night), and severe (pain at rest and spontaneous gangrene) symptoms. The serum levels of TGFβ, IL6, TNFα, and IFNγwere determinedby the ELISA method and compared among the groups. Results: The first three predominant symptoms were pulse disorder (n = 76, 95.00%), cold intolerance (n = 61, 76.25%), and claudication (n = 59, 73.75%). A comparison of the analysis of covariance (ANCOVA) revealed that both TGFβ and IL6 were dysregulatedas the severity of the symptoms increased from the moderate to the severe stages; however, such changes were not significant(p > 0.05). In the multiple logistic regression model, increased TNFαlevelswere seen in the presence of the moderatesymptoms as compared to the severe ones (p < 0.05). Conclusion: It could be concluded that TNFα, as part of the defining cytokine-production profile of Thelper cells, can be significantly involved in the progression of TAO from the moderate to the severe stages.

Suppressors of a Cold-Sensitive Mutation in Yeast U4 RNA Define Five Domains in the Splicing Factor Prp8 That Influence Spliceosome Activation

Genetics ◽  
2000 ◽  
Vol 155 (4) ◽  
pp. 1667-1682 ◽  
Author(s):  
Andreas N Kuhn ◽  
David A Brow
Keyword(s):  
Large Scale ◽  
Splicing Factor ◽  
Cold Sensitivity ◽  
Splicing Factors ◽  
Loss Of Function ◽  
U1 Snrnp ◽  
Snrnp Protein ◽  
Cold Sensitive ◽  
Spliceosome Activation ◽  
U4 Rna

AbstractThe highly conserved splicing factor Prp8 has been implicated in multiple stages of the splicing reaction. However, assignment of a specific function to any part of the 280-kD U5 snRNP protein has been difficult, in part because Prp8 lacks recognizable functional or structural motifs. We have used a large-scale screen for Saccharomyces cerevisiae PRP8 alleles that suppress the cold sensitivity caused by U4-cs1, a mutant U4 RNA that blocks U4/U6 unwinding, to identify with high resolution five distinct regions of PRP8 involved in the control of spliceosome activation. Genetic interactions between two of these regions reveal a potential long-range intramolecular fold. Identification of a yeast two-hybrid interaction, together with previously reported results, implicates two other regions in direct and indirect contacts to the U1 snRNP. In contrast to the suppressor mutations in PRP8, loss-of-function mutations in the genes for two other splicing factors implicated in U4/U6 unwinding, Prp44 (Brr2/Rss1/Slt22/Snu246) and Prp24, show synthetic enhancement with U4-cs1. On the basis of these results we propose a model in which allosteric changes in Prp8 initiate spliceosome activation by (1) disrupting contacts between the U1 snRNP and the U4/U6-U5 tri-snRNP and (2) orchestrating the activities of Prp44 and Prp24.

scholarly journals Epidemiological patterns and preventability of trauma leading to finger amputation

Sigurnost ◽  
2017 ◽  
Vol 59 (1) ◽  
pp. 1-5
Author(s):  
Hamid Namizi ◽  
Hamideh Mahdaviazad ◽  
Amir Reza Vosoughi ◽  
Zeinab Kargar Shouroki
Keyword(s):  
Finger Amputation

SAŽETAK: Amputacija prsta čest je javnozdravstveni problem koji je moguće spriječiti. Studija definira epidemiologiju amputacije prsta kako bi se utvrdili najvažniji čimbenici i predložila strategija prevencije. Studija je provedena 2015. u glavnoj sveučilišnoj ortopedskoj bolnici u Shirazu. U studiju su bili uključeni svi bolesnici s bilo kojom vrstom amputacije prsta. Za svakog bolesnika je popunjen i analiziran upitnik s demografskim podacima i tipom ozljede. Sudjelovalo je 100 bolesnika (92 muškarca i 9 žena, prosječne dobi 32.5 ± 18 godina). Najveći broj bolesnika bili su mlađi muškarci. Više od polovice (53 slučaja) pretrpjeli su ozljede na radu u vezi s radom. Amputacija prsta zbog nagnječenja u vratima bila je drugi najčešći uzrok amputacije (18 %). Približno 59 % ozlijeđenih navelo je nepažnju pri radu kao uzrok nezgode. Amputacije prsta desne ruke bile su brojčano jednake amputacijama na lijevoj ruci. Najviše je bilo amputacija kažiprsta (27 %) i srednjeg prsta (2 %). Utvrđeno je da su mlađi, slabije obrazovani muškarci te početnici na poslu podložni najvećem riziku od amputacije prstiju, naročito ako imaju povijest zlouporabe droga. Hitno je potrebno provesti sljedeće učinkovite mjere: veći nadzor, više programa osposobljavanja, otkrivanje ovisnosti o drogama i korištenje sigurnijih strojeva.

Secondary finger amputation after a work accident

2021 ◽  
pp. 102968
Author(s):  
Germain Pomares ◽  
Henry Coudane ◽  
François Dap ◽  
Gilles Dautel
Keyword(s):  
Finger Amputation ◽  
Work Accident

scholarly journals Cold Sensitivity and Other Phenotypes Resulting from Mutation in PyrA Gene

1969 ◽  
Vol 244 (15) ◽  
pp. 4039-4045
Author(s):  
A Abd-El-Al ◽  
J L Ingraham
Keyword(s):  
Cold Sensitivity

scholarly journals A Unique Case of Replantation of Previously Replanted Fingers

2021 ◽  
Author(s):  
Ravindra Bharathi ◽  
Praveen Bhardwaj ◽  
Vigneswaran Varadharajan ◽  
Hari Venkatramani ◽  
S Raja Sabapathy
Keyword(s):  
Patient Satisfaction ◽  
Literature Search ◽  
Standard Of Care ◽  
Unique Case ◽  
High Patient Satisfaction ◽  
Finger Amputation ◽  
Accepted Standard ◽  
Technical Challenges

AbstractReplantation of digital amputations is now the accepted standard of care. However, rarely will a replantation surgeon be presented with amputated fingers which have been previously replanted. In our literature search, we could find only one publication where a replanted thumb suffered amputation and was successfully replanted again. We report the technical challenges and the outcome of replanting two fingers which suffered amputation 40 months after the initial replantation and were successfully replanted again. Replantation was critical since the amputated fingers were the only two complete fingers in that hand which had initially suffered a four-finger amputation. The second-time replantation of previously replanted fingers is reported to allay the concern of the reconstructive surgeon when faced with this unique situation of “repeat amputation of the replanted finger.” Second-time replantation is feasible and is associated with high-patient satisfaction. Replantation must be attempted especially in the event of multiple digit amputations.

scholarly journals The tubulin cofactor A is involved in hyphal growth, conidiation and cold sensitivity in Fusarium asiaticum

2015 ◽  
Vol 15 (1) ◽  
pp. 35 ◽  
Author(s):  
Xiaoping Zhang ◽  
Xiang Chen ◽  
Jinhua Jiang ◽  
Menghao Yu ◽  
Yanni Yin ◽  
...  
Keyword(s):  
Hyphal Growth ◽  
Cold Sensitivity ◽  
Fusarium Asiaticum

Sequential cold-sensitive mutations in Aspergillus fumigatus

1978 ◽  
Vol 24 (2) ◽  
pp. 84-88 ◽  
Author(s):  
Ole Nielsen ◽  
Kenneth F. Gregory
Keyword(s):  
Aspergillus Fumigatus ◽  
Type A ◽  
Maximum Growth ◽  
Cold Sensitivity ◽  
Nonpermissive Temperature ◽  
Wild Type ◽  
Cold Sensitive ◽  
Wild Type Parent ◽  
Thermotolerant Fungus

Mutants of the thermotolerant fungus Aspergillus fumigatus I-21 (ATCC 32722) unable to grow at 37 °C were sought. Cold-sensitive mutants were enriched from progeny spores of γ-irradiated conidia by two or more incubations at various nonpermissive temperatures alternating with filtrations through cheesecloth. The approximate minimum, optimum, and maximum growth temperatures of the parent were 12, 40, and 50 °C, respectively. Mutants unable to grow at 37 °C were not successfully isolated directly from the wild type. A mutant unable to grow at 25 °C was isolated and mutations further increasing the cold sensitivity by increments of 3–5 °C were found to occur. Mutants completely unable to grow at 37 °C were obtained by five sequential mutations. All mutants grew as fast as the wild-type parent at 45 °C and higher. Each mutant produced revenants able to grow not only at the nonpermissive temperature used for its isolation but also at lower temperatures.

Cryostat Injury with Distal Finger Amputation Repaired Using a Composite Graft

2012 ◽  
Vol 38 (5) ◽  
pp. 803-806
Author(s):  
Marissa G. Bucci ◽  
Glenn D. Goldman
Keyword(s):  
Composite Graft ◽  
Finger Amputation
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