scholarly journals Association of secondary displacement of distal radius fractures with cortical bone quality at the distal radius

2020 ◽  
Author(s):  
A. M. Daniels ◽  
H. M. J. Janzing ◽  
C. E. Wyers ◽  
B. van Rietbergen ◽  
L. Vranken ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Strength ◽  
Distal Radius ◽  
Bone Quality ◽  
Bone Microarchitecture ◽  
Patient Characteristics ◽  
Secondary Fracture ◽  
Fracture Displacement ◽  
Secondary Displacement ◽  
Primary Reduction

Abstract Introduction The aim of this study was to investigate the associations of patient characteristics, bone mineral density (BMD), bone microarchitecture and calculated bone strength with secondary displacement of a DRF based on radiographic alignment parameters. Materials and methods Dorsal angulation, radial inclination and ulnar variance were assessed on conventional radiographs of a cohort of 251 patients, 38 men and 213 women, to determine the anatomic position of the DRF at presentation (primary position) and during follow-up. Secondary fracture displacement was assessed in the non-operatively treated patients (N = 154) with an acceptable position, preceded (N = 97) or not preceded (N = 57) by primary reduction (baseline position). Additionally, bone microarchitecture and calculated bone strength at the contralateral distal radius and tibia were assessed by HR-pQCT in a subset of, respectively, 63 and 71 patients. Outcome Characteristics of patients with and without secondary fracture displacement did not differ. In the model with adjustment for primary reduction [OR 22.00 (2.27–212.86), p = 0.008], total [OR 0.16 (95% CI 0.04–0.68), p = 0.013] and cortical [OR 0.19 (95% CI 0.05–0.80], p = 0.024] volumetric BMD (vBMD) and cortical thickness [OR 0.13 (95% CI 0.02–0.74), p = 0.021] at the distal radius were associated with secondary DRF displacement. No associations were found for other patient characteristics, such as age gender, BMD or prevalent vertebral fractures. Conclusions In conclusion, our study indicates that besides primary reduction, cortical bone quality may be important for the risk of secondary displacement of DRFs.

Dental Cone Beam Computed Tomography for Trabecular Bone Quality Analysis in Maxilla and Mandible

2021 ◽  
pp. 542-564
Author(s):  
T. Christy Bobby ◽  
Shwetha V. ◽  
Vijaya Madhavi
Keyword(s):  
Trabecular Bone ◽  
Bone Strength ◽  
Bone Quality ◽  
Bone Microarchitecture ◽  
Quality Analysis ◽  
Trabecular Bone Microarchitecture ◽  
The Stability ◽  
Maxilla And Mandible ◽  
Trabecular Bone Quality ◽  
Implant Treatment

The stability of a dental implant is one of the most important aspects that decide the success rate of implant treatment. The stability is considerably affected by the strength of trabecular bone present in maxilla and mandible. Thus, finding of trabecular bone strength is a key component for the success of dental implants. The trabecular bone strength is usually assessed by quantity of bone in terms of bone mineral density (BMD). Recently, it has been revealed that along with quantity of bone, strength of the bone also depends on quality features commonly referred as trabecular bone microarchitecture. Since the quality of the trabecular bone is varying across the maxilla and mandible, preoperative assessment of trabecular bone microarchitecture at sub-region of maxilla and mandible are essential for stable implant treatment. Thus, in this chapter, the authors inscribe the quantitative analysis of trabecular bone quality in maxilla and mandible using CBCT images by employing contourlet transform.

scholarly journals Bone microarchitecture and estimated bone strength in men with active acromegaly

2017 ◽  
Vol 177 (5) ◽  
pp. 409-420 ◽  
Author(s):  
Paula P B Silva ◽  
Fatemeh G Amlashi ◽  
Elaine W Yu ◽  
Karen J Pulaski-Liebert ◽  
Anu V Gerweck ◽  
...  
Keyword(s):  
Bone Density ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Bone Strength ◽  
Bone Microarchitecture ◽  
Healthy Controls ◽  
Trabecular Bone Density ◽  
Trabecular Bone Microarchitecture ◽  
Skeletal Site ◽  
Active Acromegaly

Context Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by microfinite element analysis (µFEA). Objective To elucidate both cortical and trabecular bone microarchitecture and estimated bone strength in men with active acromegaly or GHD compared to healthy controls. Design and subjects Cross-sectional study at a clinical research center, including 48 men (16 with acromegaly, 16 with GHD and 16 healthy controls). Outcome measures Areal bone mineral density (aBMD), cortical and trabecular bone microarchitecture and estimated bone strength (µFEA) at the radius and tibia. Results aBMD was not different between the 3 groups at any skeletal site. At the radius, patients with acromegaly had greater cortical area (P < 0.0001), cortical thickness (P = 0.0038), cortical pore volume (P < 0.0001) and cortical porosity (P = 0.0008), but lower trabecular bone density (P = 0.0010) compared to controls. At the tibia, patients with acromegaly had lower trabecular bone density (P = 0.0082), but no differences in cortical bone microstructure. Compressive strength and failure load did not significantly differ between groups. These findings persisted after excluding patients with hypogonadism. Bone microarchitecture was not deficient in patients with GHD. Conclusions Both cortical and trabecular microarchitecture are altered in men with acromegaly. Our data indicate that GH excess is associated with distinct effects in cortical vs trabecular bone compartments. Our observations also affirm the limitations of aBMD testing in the evaluation of patients with acromegaly.

scholarly journals Sarcopenic Obesity Indices Are Major Determinants of Bone Strength in Older Adults With Obesity

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A239-A239
Author(s):  
Giulia Gregori ◽  
Arjun Paudyal ◽  
Yann Barnouin ◽  
Alessandra Celli ◽  
Reina Condevillamar Villareal ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Function ◽  
Grip Strength ◽  
Bone Strength ◽  
Distal Radius ◽  
Bone Quality ◽  
Gait Speed ◽  
Failure Load ◽  
Knee Extension ◽  
Knee Extension Strength

Abstract Background: The increasing number of older adults with obesity is a growing public health problem because of increased risk of fractures especially at the ankle and upper leg despite normal or high bone mineral density. Among the contributory factors for fracture risk in this population may be aging- and obesity- associated physical frailty and impaired bone quality. However, how the adverse changes in physical function and body composition in this aging and obese population contribute to bone quality as assessed by finite element analyses (FEA) of bone strength has not been determined. Methods: One-hundred sixty-nine older (age ≥ 65 yrs.) adults with obesity (BMI ≥ 30 kg/m2) were recruited to participate in lifestyle intervention trials at our Medical Center. All underwent baseline measurements of bone strength (failure load [N] and stiffness [N.mm-1]) as estimated using FEA from high-resolution peripheral quantitative tomography (HR-pQCT) of the distal radius and tibia. In addition, body composition (appendicular lean mass/BMI [ALMBMI], fat mass/height2 [FMI]) was assessed by dual-energy x-ray absorptiometry (DXA) and physical function by the modified physical performance test (PPT), knee extension strength (isokinetic dynamometry), hand grip strength, and 4-meter gait speed. Results: Bivariate analyses showed that ALMBMI (r=.57 to .58), FMI (r=-.16 to -.17), gait speed (r=.20 to .21), grip strength (.56 to .57), and knee extension strength (r=.40 to .42) correlated with stiffness and failure load at the distal radius (all P&lt;0.05). In addition, ALMBMI (r=.65 to .67), FMI (r=-.22 to .23), gait speed (r+.18 to .19), grip strength (r=.58 to .59), and knee extension strength (r=.44 to .45) correlated with stiffness and failure load at the distal tibia (all P&lt;0.05). Controlling for age and sex, multiple regression analyses revealed that ALMBMI (β=.34 to .35) and grip strength (β=.28 to .29) were the independent predictors of stiffness and failure load at the distal radius, explaining 45% to 46% of the variance in stiffness and failure load (P&lt;0.001). On the other hand, multiple regression analyses revealed that ALMBMI (β=.45 to .52), grip strength (β=.27 to .28), and FMI (β=.17 to .18) were the independent predictors of stiffness and failure load at the distal tibia, explaining 74% to 75% of the variance in stiffness and failure load (P&lt;0.001). Conclusions: These findings suggest the importance of preserving muscle mass while reducing fat mass and improving physical function to maintain bone quality and decrease the risk of fractures when older adults with obesity undergo lifestyle intervention.

Relationships Between Stiffness of Human Distal Tibia, Distal Radius, Proximal Femur, and Vertebral Body Assessed by HR-pQCT and cQCT Based Finite Element Analyses

2009 ◽  
Author(s):  
X. Sherry Liu ◽  
Adi Cohen ◽  
Perry T. Yin ◽  
Joan M. Lappe ◽  
Robert R. Recker ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Mechanical Properties ◽  
Finite Element ◽  
Lumbar Spine ◽  
Fracture Risk ◽  
Cortical Bone ◽  
Bone Strength ◽  
Distal Radius ◽  
Proximal Femur ◽  
Quantitative Computed Tomography

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a promising clinical tool that permits separate measurements of trabecular and cortical bone compartments at the distal radius and tibia. It has an isotropic voxel size of 82 μm, which is high enough to assess the fine microstructural details of trabecular architecture. HR-pQCT images can also be used for building microstructural finite element (μFE) models to estimate the mechanical competence of whole bone segments. Melton et al. showed that derived bone strength parameters (axial rigidity and fall load to failure load ratio) are additional to BMD and bone geometry and microstructure as determinants of forearm fracture risk prediction [1]. Boutroy et al. found that the proportion of the load carried by trabecular bone versus cortical bone is associated with wrist fracture independently of BMD and microarchitecture [2]. These clinical studies demonstrate that HR-pQCT based μFE analyses can provide measurements of mechanical properties that independently associate with fracture risk. However, microstructure of one skeletal site may be different from that of another site. It is unclear whether and to what extent these peripheral measurements reflect the bone strength of the proximal femur and vertebral bodies, the sites of frequent osteoporotic fractures. Currently, central quantitative computed tomography (cQCT) is the most commonly used clinical imaging modality to quantify the structural and mechanical properties of the proximal femur and lumbar spine. We therefore evaluated relationships between the stiffness of the distal radius and tibia estimated by HR-pQCT-based FEA with that of the proximal femur and lumbar spine which was estimated from cQCT-based FEA in the same human subjects.

scholarly journals 7T MRI of distal radius trabecular bone microarchitecture: How trabecular bone quality varies depending on distance from end-of-bone

2016 ◽  
Vol 45 (3) ◽  
pp. 872-878 ◽  
Author(s):  
Lindsay M. Griffin ◽  
Stephen Honig ◽  
Cheng Chen ◽  
Punam K. Saha ◽  
Ravinder Regatte ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Distal Radius ◽  
Bone Quality ◽  
Bone Microarchitecture ◽  
Trabecular Bone Microarchitecture ◽  
Trabecular Bone Quality

Predicted age-related declines in distal radius bone strength are similar in women and men despite differences in age-related changes in bone microarchitecture

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S33
Author(s):  
H.M. Macdonald ◽  
K.K. Nishiyama ◽  
J. Kang ◽  
D.A. Hanley⁎ ◽  
S.K. Boyd
Keyword(s):  
Bone Strength ◽  
Distal Radius ◽  
Bone Microarchitecture ◽  
Age Related ◽  
Age Related Changes

Dental Cone Beam Computed Tomography for Trabecular Bone Quality Analysis in Maxilla and Mandible

2019 ◽  
pp. 151-177
Author(s):  
T. Christy Bobby ◽  
Shwetha V. ◽  
Vijaya Madhavi
Keyword(s):  
Trabecular Bone ◽  
Bone Strength ◽  
Bone Quality ◽  
Bone Microarchitecture ◽  
Quality Analysis ◽  
Trabecular Bone Microarchitecture ◽  
The Stability ◽  
Maxilla And Mandible ◽  
Trabecular Bone Quality ◽  
Implant Treatment

The stability of a dental implant is one of the most important aspects that decide the success rate of implant treatment. The stability is considerably affected by the strength of trabecular bone present in maxilla and mandible. Thus, finding of trabecular bone strength is a key component for the success of dental implants. The trabecular bone strength is usually assessed by quantity of bone in terms of bone mineral density (BMD). Recently, it has been revealed that along with quantity of bone, strength of the bone also depends on quality features commonly referred as trabecular bone microarchitecture. Since the quality of the trabecular bone is varying across the maxilla and mandible, preoperative assessment of trabecular bone microarchitecture at sub-region of maxilla and mandible are essential for stable implant treatment. Thus, in this chapter, the authors inscribe the quantitative analysis of trabecular bone quality in maxilla and mandible using CBCT images by employing contourlet transform.

scholarly journals Consumption of Rabbiteye Blueberry Results in Accumulation of Hippuric Acid in the Bone Marrow and Increased Bone Deposition in Ovariectomized Rats but Few Other Bone Benefits (P06-064-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Maria Maiz ◽  
Hawi Debelo ◽  
Pamela Lachcik ◽  
Mary Lila ◽  
Teresita Bellido ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cortical Bone ◽  
Bone Strength ◽  
Phenolic Acid ◽  
Hippuric Acid ◽  
Bone Microarchitecture ◽  
Ovariectomized Rats ◽  
Calcium Balance ◽  
Calcium Kinetics ◽  
Bone Deposition

Abstract Objectives Determine the effects of an 8-wk chronic consumption of two different blueberry varieties at varying doses on calcium balance, calcium kinetics, bone microarchitecture and polyphenol metabolism and distribution in ovariectomized rats. Methods Eighty 5-mo old ovariectomized rats were sorted by weight and block-randomized to an 8-wk chronic feeding treatment of a polyphenol-free (control), 2.5% or 5% `Montgomery ́ (Mont) rabbiteye blueberry (V. ashei) or 5% wild lowbush blueberry (Wild BB) (V. angustifolium) (% w/w). During week 0 and week 8, rats went through a calcium balance study to determine calcium absorption and retention. At the end of week 8, rats were dosed with 45Ca and serial blood draws were done from baseline up to 48 h post-dose to map Ca kinetics. At sacrifice, the right femur was collected to determine differences in bone strength and microarchitecture of trabecular and cortical bone through MicroCT and a three-point bending test. A 24 h urine collection was done at baseline and during week 8 of treatment to determine urinary phenolic acid excretion and the left femur bone marrow phenolic acid accumulation through UPLC-MS/MS. Results A blueberry enriched diet had no effect on cortical bone microarchitecture, with a trend towards increased trabecular bone protection (p = 0.08). No differences were observed in bone strength. During baseline, a 2.5% Mont diet significantly increased Ca retention, but the effect was lost after the 8 weeks of treatment when rats had stabilized to treatment. Calcium kinetics showed that Mont 5% significantly increased Ca absorption and bone turnover (p < 0.05), while Mont 2.5% and Wild BB 5% did not. An accumulation of hippuric acid in the bone marrow was detected with the Mont blueberry treatments and it was significantly and positively correlated with bone deposition. The metabolism of phenolic acids was significantly affected by a chronic consumption of the treatment diets, resulting in significant phenolic acid profiles and excretion shifts. Conclusions A blueberry-enriched diet had minimal effects on bone after stabilized to ovariectomy and the effects differ depending on blueberry variety and dose. Funding Sources National Institute of Health (NIH) and National Center for Complementary and Integrative Health (NCCIH).

scholarly journals Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT

Bone ◽  
2010 ◽  
Vol 47 (3) ◽  
pp. 519-528 ◽  
Author(s):  
Andrew J. Burghardt ◽  
Helen R. Buie ◽  
Andres Laib ◽  
Sharmila Majumdar ◽  
Steven K. Boyd
Keyword(s):  
Cortical Bone ◽  
Distal Radius ◽  
Bone Microarchitecture

Osteocytes and cortical bone quality in human bone diseases

2014 ◽  
Author(s):  
Bjorn Busse
Keyword(s):  
Cortical Bone ◽  
Bone Quality ◽  
Bone Diseases ◽  
Human Bone
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