Do prophylactic antibiotics in gynecologic surgery prevent postoperative inflammatory complications? A systematic review

2017 ◽  
Vol 295 (6) ◽  
pp. 1383-1391 ◽  
Author(s):  
Cedric Emanuel Boesch ◽  
Roderick Franziskus Pronk ◽  
Fabian Medved ◽  
Pascal Hentschel ◽  
Hans-Eberhard Schaller ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prophylactic Antibiotics ◽  
Gynecologic Surgery ◽  
Postoperative Inflammatory Complications

Impact of frailty in benign gynecologic surgery: a systematic review

2021 ◽  
Author(s):  
Jacqueline Y. Kikuchi ◽  
Katerina Hoyt ◽  
Andrea I. Nomura ◽  
Sindhura Vallabhaneni ◽  
Jaime Blanck ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gynecologic Surgery

scholarly journals Efficacy of pre-operative pharmacologic thromboprophylaxis on incidence of venous thromboembolism following major gynecologic and gynecologic oncology surgery: a systematic review and meta-analysis

2020 ◽  
pp. ijgc-2020-001991
Author(s):  
Steven Bisch ◽  
Rachelle Findley ◽  
Christina Ince ◽  
Maria Nardell ◽  
Gregg Nelson
Keyword(s):  
Systematic Review ◽  
Venous Thromboembolism ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Gynecologic Oncology ◽  
Quality Data ◽  
Gynecologic Surgery ◽  
Cochrane Central Register ◽  
Pharmacologic Prophylaxis ◽  
Pharmacologic Thromboprophylaxis

IntroductionVenous thromboembolism remains a significant complication following major gynecologic surgery. Evidence is lacking on whether it is beneficial to give pharmacologic thromboprophylaxis pre-operatively. The aim of this meta-analysis was to assess the role of pre-operative pharmacologic thromboprophylaxis in preventing post-operative venous thromboembolism.MethodsPubMed, EMBASE, and the Cochrane Central Register of Clinical Trials were searched to find randomized controlled, cohort, and case–control trials comparing pre-operative pharmacologic thromboprophylaxis to no prophylaxis, mechanical prophylaxis, or only post-operative pharmacologic thromboprophylaxis for open and minimally invasive major gynecologic surgery (benign and malignant conditions). Two authors independently assessed abstracts, full-text articles, and methodological quality. Data were extracted and pooled using ORs for random effects meta-analysis. Heterogeneity was explored using forest plots, Q-statistic, and I2 statistics. Planned subgroup analysis of use of sequential compression devices, equivalent versus non-equivalent post-operative prophylaxis, cancer diagnosis, and methodological quality were performed.ResultsSome 503 unique studies were found, and 16 studies (28 806 patients) were included in the systematic review. Twelve studies (14 273 patients) were included in the meta-analysis. The OR for incidence of post-operative venous thromboembolism was 0.59 (95% CI 0.39, 0.89), favoring pre-operative pharmacologic thromboembolism prophylaxis compared with no pre-operative pharmacologic prophylaxis (Q=13.80, I2=20.30). In studies where post-operative care was equivalent between groups, the OR for venous thromboembolism was 0.56 (95% CI 0.22, 1.40). Pre-operative pharmacologic prophylaxis demonstrated greatest benefit when utilized with both intra-operative and post-operative sequential compression devices (OR 0.43, 95% CI 0.30, 0.64) compared with when no sequential compression devices were utilized (OR 1.27, 95% CI 0.63, 2.56). When looking at only studies determined to be of high quality, the results no longer reached significance (OR 0.73, 95% CI 0.36, 1.46).ConclusionsPre-operative pharmacologic thromboprophylaxis decreases the odds of venous thromboembolism in the peri-operative period for major gynecologic oncology surgery by approximately 40%. It remains unclear whether this benefit is present in benign and minor procedures. Adequately powered studies are needed.

Postoperative Prophylactic Antibiotics Reduce Surgical Site Infection Rates after Ventral Hernia Repair: A Systematic Review

2019 ◽  
Vol 85 (11) ◽  
pp. 1228-1233
Author(s):  
Pablo A. Baltodano ◽  
Anmol Chattha ◽  
Philip K. Johnson ◽  
Justin Kittredge ◽  
Joseph A. Ricci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hernia Repair ◽  
Ventral Hernia ◽  
Ventral Hernia Repair ◽  
Prophylactic Antibiotics ◽  
Control Group ◽  
Infection Rates ◽  
The Impact ◽  
Independent Assessment

SSIs after ventral hernia repair (VHR) represent a significant complication. The impact of postoperative prophylactic antibiotics on the SSI rates after VHRs is unclear. A systematic review of PubMed and Web of Science databases from inception through March 2016 investigating the effect of postoperative prophylactic antibiotics after VHRs was performed. Strict inclusion and exclusion criteria were implemented, and the methodological quality of the included studies was assessed. After systematic independent assessment of 216 citations, four studies, involving 344 patients, met the inclusion criteria. Among the included studies, 164 patients received >24 hours of postoperative prophylactic antibiotics, whereas 180 patients were controls. The overall incidence of SSI among patients receiving postoperative antibiotics was 14.6 per cent (95% confidence interval [CI], 9.9 to 20.9) which compares favorably with the control group: 35.5 per cent (95% CI, 28.9 to 42.7) (odds ratio: 0.3, 95% CI: 0.2 to 0.5, P < 0.01). Among patient's receiving postoperative antibiotics, the pooled average duration of postoperative antibiotic treatment was 6.2 ± 0.4 days. Based on the available evidence, the use of postoperative prophylactic antibiotics seems to be associated with lower SSI rates after VHRs. Future prospective randomized controlled trials should be conducted to further confirm the efficacy of this prophylactic intervention.

Management of recurrent acute otitis media in children: systematic review of the effect of different interventions on otitis media recurrence, recurrence frequency and total recurrence time

2012 ◽  
Vol 126 (9) ◽  
pp. 874-885 ◽  
Author(s):  
K H Cheong ◽  
S S M Hussain
Keyword(s):  
Systematic Review ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Prophylactic Antibiotics ◽  
Recurrence Time ◽  
Tympanostomy Tube ◽  
Tube Insertion ◽  
Hand Search ◽  
Randomised Controlled ◽  
Recurrence Frequency

AbstractObjective:To conduct a systematic review comparing the effect of three interventions (prophylactic antibiotics, tympanostomy tube insertion and adenoidectomy) on otitis media recurrence, recurrence frequency and total recurrence time.Methods:Literature on recurrent otitis media was identified using the PubMed and Scopus search engines for the period January 1990 to March 2011. A hand search of the reference lists of relevant articles and textbooks was conducted to identify additional studies. Randomised, controlled trials with a minimum of 40 children and follow up of at least 12 months were included.Results:Eighteen publications were identified. Each was assessed using preset inclusion criteria; seven publications met these criteria.Conclusion:Prophylactic antibiotics are effective in reducing otitis media recurrence, recurrence frequency and total recurrence time. Tympanostomy tube insertion failed to reduce the prevalence of otitis media recurrence, but reduced the recurrence frequency and total recurrence time. Adenoidectomy reduced otitis media recurrence; results on otitis media recurrence frequency differed but on average there was a reduction; however, the two studies with relevant data on total recurrence time had contradictory results.

scholarly journals Prophylactic antibiotics before cord clamping in cesarean delivery: a systematic review

2017 ◽  
Vol 97 (5) ◽  
pp. 521-535 ◽  
Author(s):  
Claudia Bollig ◽  
Monika Nothacker ◽  
Cornelius Lehane ◽  
Edith Motschall ◽  
Britta Lang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cesarean Delivery ◽  
Prophylactic Antibiotics ◽  
Cord Clamping

A Systematic Review of Perioperative Versus Prophylactic Antibiotics for Cochlear Implantation

2016 ◽  
Vol 125 (11) ◽  
pp. 893-899 ◽  
Author(s):  
Samantha Anne ◽  
Stacey L. Ishman ◽  
Seth Schwartz
Keyword(s):  
Systematic Review ◽  
Cochlear Implantation ◽  
Prophylactic Antibiotics

Prophylactic antibiotics in urodynamics: A systematic review of effectiveness and safety

2007 ◽  
Vol 27 (3) ◽  
pp. 167-173 ◽  
Author(s):  
Pallavi M. Latthe ◽  
Richard Foon ◽  
Philip Toozs-Hobson
Keyword(s):  
Systematic Review ◽  
Prophylactic Antibiotics
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