Does prior traumatization affect the treatment outcome of CBT for panic disorder? The potential role of the MAOA gene and depression symptoms

OBJECTIVE:Although there has been a link between certain types of pain, notably chest pain, and panic disorder, the relation between pain and panic disorder has not been systematically evaluated. In the present study, the relation between pain symptoms (headache, chest pain, stomach pain, joint pain) and the clinical presentation of patients with panic disorder was evaluated.HYPOTHESES:Pain was generally hypothesized to be related to increased symptoms of anxiety, panic-relevant cognitive domains and treatment outcome. In terms of specific pain domains, headache and chest pain were expected to be more closely related to anxiety-related symptoms.PARTICIPANTS AND METHODS:Patients (n=139) meeting the criteria of theDiagnostic and Statistical Manual of Mental Disorders - Fourth Editionfor panic disorder completed a set of standardized clinician-rated and self-reported measures. Moderator analyses were used in a subset of these patients completing a treatment outcome study.RESULTS:Approximately two-thirds of the participants endorsed at least one current pain symptom. The hypotheses were partially supported, with pain being associated with higher levels of anxiety and depression symptoms, as well as panic frequency. Pain was also related to several cognitive features, including anxiety sensitivity and panic appraisals. Headache and chest pain were more highly associated with anxiety symptoms than was joint pain. Cognitive measures did not mediate the relation between anxiety and pain, and pain did not significantly moderate outcome in response to cognitive-behavioural therapy.CONCLUSIONS:Co-occurring pain symptoms appear to be more highly related to phenomenology than to treatment response in patients with panic disorder.

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Massed Exposure and Fast Remission of Panic Disorder with Agoraphobia: A Case Example

Behavioural and Cognitive Psychotherapy ◽

10.1017/s135246580700361x ◽

2007 ◽

Vol 35 (3) ◽

pp. 371-375 ◽

Cited By ~ 3

Author(s):

Thomas Lang ◽

Jürgen Hoyer

Keyword(s):

Treatment Outcome ◽

Panic Disorder ◽

Male Patient ◽

Intensive Treatment ◽

Systematic Research ◽

Clinical Routine ◽

Full Remission

This case example demonstrates the role of massed exposure in optimizing treatment outcome in panic disorder with agoraphobia. Treatment of a 28-year-old male patient in a clinical routine setting is described. Full remission was achieved after an 8 day period of intensive treatment and proved to be stable at follow-up (6 months). More systematic research including controlled studies comparing massed and spaced exposure is suggested.

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Symptoms of Depression in Israeli Adolescents Following a Suicide Bombing

The Journal of Early Adolescence ◽

10.1177/0272431611400317 ◽

2011 ◽

Vol 32 (4) ◽

pp. 502-515 ◽

Cited By ~ 6

Author(s):

John P. Barile ◽

Kathryn E. Grogan ◽

Christopher C. Henrich ◽

Kathryn A. Brookmeyer ◽

Golan Shahar

Keyword(s):

Potential Role ◽

Depression Symptoms ◽

Suicide Bombing ◽

Terror Attack ◽

School Students ◽

Terror Attacks ◽

Symptoms Of Depression ◽

Before And After ◽

Depressive Vulnerability

This report investigated the potential role of gender in moderating the effects of terror attack exposure on depression symptoms in middle school students from Dimona, Israel ( N = 90). Specifically, the effects of three aspects of terror attacks were investigated: physical exposure, relational exposure, and media exposure. Ninety early adolescents were assessed for terror exposure and depression before and after a suicide bombing in a town market. Results indicate that the effects of relational exposure to the suicide bombing—knowing others directly affected by a suicide bombing—on depression symptoms differed by gender. Adolescent girls who knew people affected by the suicide bombing reacted with higher levels of depressive symptoms while similarly exposed adolescent boys did not. It may be that girls, as compared to boys, express greater sympathy for victims, and are hence more vulnerable to disruptions of their social network, resulting in a heightened depressive vulnerability.

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Potential role of calprotectin as a monitoring biomarker for clinical and sonographic activity and treatment outcome in recent-onset rheumatoid arthritis

Egyptian Rheumatology and Rehabilitation ◽

10.4103/1110-161x.189824 ◽

2016 ◽

Vol 43 (3) ◽

pp. 143 ◽

Cited By ~ 1

Author(s):

BasantM Elnady ◽

AmalF Soliman ◽

RaneyahH Mahmoud Shaker ◽

AmiraI Mansour

Keyword(s):

Rheumatoid Arthritis ◽

Treatment Outcome ◽

Potential Role ◽

Recent Onset

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The Potential Role of Tomudex in the Treatment of Advanced Colorectal Cancer

Tumori Journal ◽

10.1177/030089169708300220 ◽

1997 ◽

Vol 83 (2) ◽

pp. 576-580 ◽

Cited By ~ 2

Author(s):

Alberto F. Sobrero

Keyword(s):

Colorectal Cancer ◽

Treatment Outcome ◽

Potential Role ◽

Advanced Colorectal Cancer ◽

Toxicity Profile ◽

Pros And Cons ◽

Synthase Inhibitor ◽

Near Future

Aims and Background The quinazoline folate analog thymidylate synthase inhibitor, Tomudex, is about to enter the Italian pharmaceutical market. Its place among the therapeutic options for advanced colorectal cancer is discussed. Methods The pros and cons of currently available chemotherapeutic regimens are briefly described with special attention to patient's and tumor's determinants of treatment outcome. The mechanism of action and the results of phase I, II and III studies of Tomudex are reviewed. Results Not all patients need to be treated. Guidelines are given in this respect. Tomudex at the dose of 3 mg/m2 given i.v. every three weeks has antitumor activity similar to that of currently available regimens, with a favorable toxicity profile. Conclusions Current research approaches are unlikely to dramatically improve the treatment outcome of this disease in the near future. What can reasonably be expected is less toxicity and more convenient routes and schedules of drug administration that may translate into better quality of life for our patients. Tomudex has been devised along these lines.

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The role of therapist and patient in-session behavior for treatment outcome in exposure-based cognitive behavioral therapy for panic disorder with agoraphobia

Journal of Clinical Psychology ◽

10.1002/jclp.22738 ◽

2018 ◽

Vol 75 (4) ◽

pp. 614-626 ◽

Cited By ~ 1

Author(s):

Lisa M. Maiwald ◽

Yvonne M. Junga ◽

Thomas Lang ◽

Romina Montini ◽

Michael Witthöft ◽

...

Keyword(s):

Treatment Outcome ◽

Panic Disorder ◽

Cognitive Behavioral Therapy ◽

Behavioral Therapy ◽

Cognitive Behavioral

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The Potential Role of Serotonergic Hallucinogens in Depression Treatment

Life ◽

10.3390/life11080765 ◽

2021 ◽

Vol 11 (8) ◽

pp. 765

Author(s):

Dominika Psiuk ◽

Emilia Nowak ◽

Krystian Cholewa ◽

Urszula Łopuszańska ◽

Marzena Samardakiewicz

Keyword(s):

Potential Role ◽

Comparable Efficacy ◽

Depression Symptoms ◽

Serious Adverse Events ◽

Symptoms Of Depression ◽

Treatment Of Depression ◽

Novel Method ◽

Psychological Scales ◽

Novel Therapeutic Strategies

Due to an increasing number of depression diagnoses and limited effective treatments, researchers continue to explore novel therapeutic strategies for this disorder. Recently, interest has revolved around the use of serotonergic psychedelics to reduce the symptoms of depression. In this systematic review, we summarize the currently available knowledge on the safety and efficacy of psychedelic substances for the treatment of depression. A literature search of the PubMed/MEDLINE database identified 14 clinical trials from the last 10 years that examined the use of psilocybin, MDMA, DMT, or LSD for the treatment of depression symptoms. Some psychedelics, especially psilocybin, demonstrated an ability to reduce depressive symptoms as measured by several psychological scales, which was often sustained for months after the last psychedelic session. Moreover, one study revealed that psilocybin has comparable efficacy to escitalopram in the treatment of depression. None of the studies reported any serious adverse events associated with psychedelic administration. The reviewed studies suggest that psychedelics have great potential in depression therapy and, after addressing and overcoming the current study limitations, may be used as a novel method of treating depression in the future.

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