Particle radiation alters expression of matrix metalloproteases resulting in ECM remodeling in human lens cells

2007 ◽  
Vol 46 (2) ◽  
pp. 187-194 ◽  
Author(s):  
P. Y. Chang ◽  
K. A. Bjornstad ◽  
C. J. Rosen ◽  
S. Lin ◽  
E. A. Blakely
Keyword(s):  
Matrix Metalloproteases ◽  
Human Lens ◽  
Particle Radiation ◽  
Ecm Remodeling ◽  
Lens Cells

MMP and TIMP Expression in Quiescent, Dividing, and Differentiating Human Lens Cells

2007 ◽  
Vol 48 (9) ◽  
pp. 4192 ◽  
Author(s):  
Lisa M. Hodgkinson ◽  
George Duncan ◽  
Lixin Wang ◽  
Caroline J. Pennington ◽  
Dylan R. Edwards ◽  
...  
Keyword(s):  
Human Lens ◽  
Lens Cells

Growth factor receptor signalling in human lens cells: role of the calcium store

2005 ◽  
Vol 80 (6) ◽  
pp. 885-895 ◽  
Author(s):  
Lixin Wang ◽  
I. Michael Wormstone ◽  
John R. Reddan ◽  
George Duncan
Keyword(s):  
Growth Factor ◽  
Growth Factor Receptor ◽  
Human Lens ◽  
Calcium Store ◽  
Receptor Signalling ◽  
Lens Cells

Particle Irradiation Induces FGF2 Expression in Normal Human Lens Cells

2000 ◽  
Vol 154 (5) ◽  
pp. 477-484 ◽  
Author(s):  
P. Y. Chang ◽  
K. A. Bjornstad ◽  
E. Chang ◽  
M. McNamara ◽  
M. H. Barcellos-Hoff ◽  
...  
Keyword(s):  
Human Lens ◽  
Particle Irradiation ◽  
Lens Cells ◽  
Fgf2 Expression ◽  
Normal Human

TGFbeta signalling through Smad-independent mechanisms in human lens cells

2008 ◽  
Vol 86 ◽  
pp. 0-0 ◽  
Author(s):  
IM WORMSTONE ◽  
JA ELDRED ◽  
LJ DAWES ◽  
JR REDDAN ◽  
L WANG
Keyword(s):  
Human Lens ◽  
Lens Cells

scholarly journals Use of Human Pluripotent Stem Cells to Define Initiating Molecular Mechanisms of Cataract for Anti-Cataract Drug Discovery

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1269
Author(s):  
Dewi ◽  
O’Connor
Keyword(s):  
Pluripotent Stem Cells ◽  
Molecular Mechanisms ◽  
Cell Types ◽  
Light Transmittance ◽  
Human Lens ◽  
Surgical Removal ◽  
Large Numbers ◽  
Different Types ◽  
Lens Cells ◽  
Cataract Patients

Cataract is a leading cause of blindness worldwide. Currently, restoration of vision in cataract patients requires surgical removal of the cataract. Due to the large and increasing number of cataract patients, the annual cost of surgical cataract treatment amounts to billions of dollars. Limited access to functional human lens tissue during the early stages of cataract formation has hampered efforts to develop effective anti-cataract drugs. The ability of human pluripotent stem (PS) cells to make large numbers of normal or diseased human cell types raises the possibility that human PS cells may provide a new avenue for defining the molecular mechanisms responsible for different types of human cataract. Towards this end, methods have been established to differentiate human PS cells into both lens cells and transparent, light-focusing human micro-lenses. Sensitive and quantitative assays to measure light transmittance and focusing ability of human PS cell-derived micro-lenses have also been developed. This review will, therefore, examine how human PS cell-derived lens cells and micro-lenses might provide a new avenue for development of much-needed drugs to treat human cataract.

Regulation of Sarco/Endoplasmic Ca2+-ATPase Expression by Calcium in Human Lens Cells

2002 ◽  
Vol 75 (5) ◽  
pp. 583-590 ◽  
Author(s):  
L Liu ◽  
C.A Paterson ◽  
D Borchman
Keyword(s):  
Human Lens ◽  
Lens Cells

scholarly journals Ovulation is Inhibited by an Environmentally Relevant Phthalate Mixture in Mouse Antral Follicles in Vitro

2020 ◽  
Author(s):  
Katie L Land ◽  
Madison E Lane ◽  
Ava C Fugate ◽  
Patrick R Hannon
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Consumer Products ◽  
Matrix Metalloproteases ◽  
Dependent Manner ◽  
Ecm Remodeling ◽  
Antral Follicles ◽  
The Matrix ◽  
Housing Materials ◽  
Ovulatory Period

Abstract Phthalates are solvents and plasticizers found in consumer products including cosmetics, food/beverage containers, housing materials, etc. Phthalates are known endocrine-disrupting chemicals that can directly target the ovary, potentially causing defects in ovulation and fertility. Women are exposed to multiple different phthalates daily, therefore this study investigated the effects of an environmentally relevant phthalate mixture (PHTmix) on ovulation. Ovulation is initiated by the luteinizing hormone (LH) surge, which induces prostaglandin (PG) production, progesterone (P4)/progesterone receptor (PGR) signaling, and extra-cellular matrix (ECM) remodeling. We hypothesized that the PHTmix would directly inhibit ovulation by altering the levels of PGs, P4/PGR, and enzymes involved in ECM remodeling. Antral follicles from CD-1 mice were treated with vehicle control alone (dimethylsulfoxide, DMSO), hCG alone (LH analog), and hCG+PHTmix (1-500μg/ml), and samples were collected across the ovulatory period. The PHTmix decreased ovulation rates at all doses tested in a dose dependent manner when compared to hCG. PG levels were decreased by the PHTmix when compared to hCG, which was potentially mediated by altered levels of PG synthesis (Ptgs2) and transport (Slco2a1) genes. The PHTmix altered P4 and Pgr levels when compared to hCG, leading to decreases in downstream PGR-mediated genes (Edn2, Il6, Adamts1). ECM remodeling was potentially dysregulated by altered levels of ovulatory mediators belonging to the matrix metalloproteases and plasminogen activator families. These data suggest that phthalate exposure inhibits ovulation by altering PG levels, P4/PGR action, and ECM remodeling.

scholarly journals Matrix Metalloproteases as Influencers of the Cells’ Social Media

2019 ◽  
Vol 20 (16) ◽  
pp. 3847 ◽  
Author(s):  
Daniel Young ◽  
Nabangshu Das ◽  
Anthonia Anowai ◽  
Antoine Dufour
Keyword(s):  
Inflammatory Diseases ◽  
Matrix Metalloproteases ◽  
Phase Iii ◽  
Biological Functions ◽  
Mmp Inhibitors ◽  
Ecm Remodeling ◽  
Surface Receptors ◽  
Phase Iii Clinical Trials ◽  
The Matrix ◽  
The Impact

Matrix metalloproteinases (MMPs) have been studied in the context of cancer due to their ability to increase cell invasion, and were initially thought to facilitate metastasis solely through the degradation of the extracellular matrix (ECM). MMPs have also been investigated in the context of their ECM remodeling activity in several acute and chronic inflammatory diseases. However, after several MMP inhibitors failed in phase III clinical trials, a global reassessment of their biological functions was undertaken, which has revealed multiple unanticipated functions including the processing of chemokines, cytokines, and cell surface receptors. Despite what their name suggests, the matrix aspect of MMPs could contribute to a lesser part of their physiological functions in inflammatory diseases, as originally anticipated. Here, we present examples of MMP substrates implicated in cell signaling, independent of their ECM functions, and discuss the impact for the use of MMP inhibitors.

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