scholarly journals Relationship among total tear IgE, specific serum IgE, and total serum IgE levels in patients with pollen-induced allergic conjunctivitis

2021 ◽  
Author(s):  
Yasuo Yamana ◽  
Satoshi Yamana ◽  
Eiichi Uchio
Keyword(s):  
Allergic Conjunctivitis ◽  
Reference Value ◽  
Japanese Cedar ◽  
Specific Ige ◽  
Total Serum ◽  
Serum Ige ◽  
Specific Serum ◽  
Number Of Patients ◽  
Significant Difference ◽  
Japanese Cedar Pollinosis

Abstract Background Recently, the number of patients with pollinosis, particularly Japanese cedar pollinosis, has markedly increased. We previously reported about local allergic conjunctivitis, which is a phenotype of allergic conjunctivitis (AC). AC cases are often sensitized by various antigens. This study aimed to investigate the relationship among total tear IgE (t-tIgE), specific serum IgE (s-sIgE), and total serum IgE (t-sIgE) levels in patients with pollen-induced AC. Methods In 2019, 1372 patients were clinically diagnosed with AC at the Yamana Eye Clinic using t-tIgE, t-sIgE, and s-sIgE tests against 39 allergens. Among the pollen-induced AC patients who underwent allergen testing, 99 tested positives for s-sIgE against pollen. The subjects comprised 33 (33.3%) male and 66 (66.7%) female individuals aged 9–86 years. Results The t-tIgE test was positive in 68 (68.7%) patients and negative in 31 (31.3%) patients. In the t-sIgE test, 45 (45.5%) patients had t-sIgE levels above the reference value of 170 IU/mL. The higher the total score of the positive class value of each pollen-specific IgE (pollen-sIgE) antibody, the higher the positive rate of t-tIgE (p < 0.001). Of 32 patients in whom food-specific IgE (food-sIgE) was detected, 81.3% of the pollen-sIgE-positive and food-sIgE-positive cases were also positive for t-sIgE and t-tIgE. However, significant difference was not found between the total score of food-sIgE of the t-tIgE positive group and negative group. Conclusions Pollen-induced AC is caused by pollen sensitization of the conjunctiva. Food-induced AC might be induced by the different pathological mechanism involved in pollen-induced AC.

scholarly journals Total IgE Distribution in Food Allergy Suspected Patients in Republic of Macedonia (2001-2011)

2015 ◽  
Vol 3 (2) ◽  
pp. 202-208
Author(s):  
Slavica Hristomanova Mitkovska ◽  
Dejan Trajkov ◽  
Aleksandar Petlichkovski ◽  
Olivija Efinska-Mladenovska ◽  
Mirko Spiroski
Keyword(s):  
Food Allergy ◽  
Human Genetics ◽  
Specific Ige ◽  
Average Concentration ◽  
Total Serum ◽  
Age Group ◽  
Total Ige ◽  
Serum Ige ◽  
Number Of Patients

BACKGROUND: IgE may be considered the hallmark of allergic disorders. It is easily detected in serum and can be measured as total IgE and as allergen-specific IgE. In fact, the serum IgE assay is used to diagnose an allergy.AIM: The aim of this study is to evaluate, investigate and present the distribution of total serum IgE levels, determined with UniCap system, in food-allergy suspected patients in a Republic of Macedonia.MATERIAL AND METHODS: In this study we analyzed retrospectively 8898 consecutive patients that were admitted for allergy testing at the Institute of Immunobiology and Human Genetics during the ten year period between 01.01.2001 and 01.01.2011. Total IgE levels in patient sera were detected with the in vitro system UniCAP100 (Pharmacia, Uppsala, Sweden).RESULTS: When we analyzed the number of patients according to the total IgE groups, we noted that most of the patients have normal levels of total IgE in serum. However, we also discovered a group of patients with elevated levels of total IgE that are greater than 200 kU/L. The average concentration of total serum IgE is higher in women in the age group 6 (6-7 years), followed by a steep decrease in the age group 9 (9-10 years), and after that the average concentrations of total IgE were mostly constant with the exception of a partial increase in the age group 21 (65-69 years). For men, the average serum concentrations of total IgE were highest in the age group of 6 (6-7 years), which was significantly higher than the average concentrations of total IgE in all other age groups.CONCLUSION: The large number of enrolled patients, a particular strength of this study, revealed that average concentrations of total IgE in men are higher than in women and that total IgE did not decrease with age. On the contrary, increased total IgE levels were found in patients aged 65 and 69 of both genders. We continue our work with analyses of the specific IgE antibodies values toward food and the correlation with total IgE values.

scholarly journals Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar Pollinosis

Allergies ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 140-149
Author(s):  
Shiori Kitaya ◽  
Nobuo Ohta ◽  
Atsushi Yuta ◽  
Yukiko Ogawa ◽  
Yusuke Suzuki ◽  
...  
Keyword(s):  
Japanese Cedar ◽  
Roc Curves ◽  
Serum Levels ◽  
Specific Ige ◽  
Ocular Symptoms ◽  
Significant Difference ◽  
Specific Igg4 ◽  
Successful Group ◽  
Japanese Cedar Pollinosis ◽  
Cedar Pollen

Purpose: To elucidate the usefulness of Japanese cedar pollen (JCP)-specific antigen-specific immunoglobulin (IgG) 4 as a biomarker for predicting the efficacy of sublingual immunotherapy for cedar pollen-induced allergic rhinitis. Methods: We divided a total of 105 cases with Japanese cedar pollinosis into three groups: “SLIT Successful,” SLIT Unsatisfactory,” and “SCIT” groups. The SLIT group patients were treated with JCP Droplet (Torii Pharmaceutical Co. Ltd., Tokyo, Japan) for one year from 2015 and were divided into two groups, the SLIT Successful group or the SLIT Unsatisfactory group. The SLIT Successful group (n = 16) were subjects treated by SLIT only, who were able to experience control of their naso-ocular symptoms without the need for antiallergic rescue agents during the peak season of atmospheric pollen. The SLIT Unsatisfactory group (n = 76) comprised subjects treated with SLIT only, who did not respond successfully, and were administered with rescue agents to control their naso-ocular symptoms. The SCIT group had been treated with standardized JCP extract (Torii Pharmaceutical Co., Ltd., Tokyo, Japan) for three years from 2012, and were also able to experience control of their symptoms during the peak pollen season without the need for antiallergic rescue agents. We determined the serum level of JCP-specific immunoglobulin E (IgE), IgG, and IgG4 used in the 3gAllergy-specific IgE assay (3gAllergy). The serum levels of periostin and SCCA2 were measured using established ELISA procedures (clones SS18A and SS17B; Shino-Test, Japan) following the manufacturer’s instructions. We then made ROC curves for each group and assessed which index was best able to predict the efficacy of sublingual immunotherapy. Results: Serum JCP-specific IgE was significantly lower in the SCIT group than in the SLIT Successful group and the SLIT Unsatisfactory group (p < 0.05). Serum JCP-specific IgG was significantly higher in the SCIT group and the SLIT Successful group than in the SLIT Unsatisfactory group (p < 0.05). Serum JCP-specific IgG4 was also significantly higher in the SCIT group and the SLIT Successful group than in the SLIT Unsatisfactory group (p < 0.05). There was no significant difference among serum levels of periostin in the SCIT group, the SLIT Successful group, or the SLIT Unsatisfactory group. There was also no significant difference in SCCA2 among the three groups. In terms of ROC curves, a serum JCP-specific IgG4 value greater than 989.5 UA/mL showed the best sensitivity (93.3%) and specificity (94.7%) (p < 0.05) among other parameters. Conclusions: The serum JCP-specific IgG4 level is significantly correlated with the clinical efficacy of SLIT. Serum JCP-specific IgG4 cutoff levels greater than 989.5 UA/mL were correlated with an effective clinical response to SLIT, with a sensitivity of 93.3% and a specificity of 94.7%.

scholarly journals Allergic Sensitization to Perennial Allergens in Adults and Children Sensitized to Japanese Cedar or Japanese Cypress Pollen in Japan

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Masafumi Ohki ◽  
Masanobu Shinogami
Keyword(s):  
Allergic Sensitization ◽  
Japanese Cedar ◽  
Specific Ige ◽  
Total Serum ◽  
Blood Eosinophil ◽  
Japanese Cypress ◽  
Serum Ige ◽  
Cell Counts ◽  
Eosinophil Cell ◽  
Perennial Allergens

In Japan, seasonal allergic rhinitis in the spring due to exposure to Japanese cedar or Japanese cypress pollen is common. However, the allergic profile for perennial allergens in spring pollinosis remains unclear. Therefore, in this study, we investigated the allergic profiles of 652 patients with rhinitis. Total serum IgE, serum-specific IgE, and blood eosinophil counts were measured. Allergic sensitization, determined by the serum allergen-specific IgE level, did not always correspond with the patient’s symptoms. Only 27% of patients with allergic symptoms in response to spring pollens were sensitized to these allergens alone; 31% of patients were also sensitized to perennial allergens, even without symptoms due to perennial allergens. Total serum IgE and eosinophil cell counts were significantly elevated in patients sensitized to perennial allergens and spring pollens, as compared to patients sensitized only to spring pollens. Most children sensitized to spring pollen (84%) were sensitized to perennial allergens, at a higher rate than adults (49%). Patients sensitized to spring pollens are likely to be latently sensitized to perennial allergens. This is especially true for children and should be monitored closely. Improvement in seasonal allergic conditions, including latent perennial allergy, is important to prevent symptoms that could advance to asthma.

scholarly journals Dietary Allergy and Specific IgE in Ulcerative Colitis

1981 ◽  
Vol 74 (4) ◽  
pp. 292-293 ◽  
Author(s):  
D B Jones ◽  
G D Kerr ◽  
J H Parker ◽  
R S E Wilson
Keyword(s):  
Ulcerative Colitis ◽  
Specific Ige ◽  
Egg White ◽  
Total Serum ◽  
Serum Ige ◽  
Significant Difference ◽  
Food Specific Ige

Previous authors have considered that allergy to certain foodstuffs may play an important role in the aetiology of ulcerative colitis, but immunological evidence for dietary allergy in ulcerative colitis is inconclusive. A study is reported of 22 patients with ulcerative colitis, with matched controls, in whom total serum IgE and specific IgE to certain foodstuffs have been estimated by the Phadebas PRIST and RAST (Pharmacia) techniques. Allergens tested were egg-white, milk, wheat, rye, oat, fish (cod) and peanut. There was no significant difference in the total serum IgE levels and the food specific IgE activity between the two groups.

scholarly journals Domestic Exposure to Fungi and Total Serum IgE Levels in Asthmatic Children

2005 ◽  
Vol 2005 (3) ◽  
pp. 167-170 ◽  
Author(s):  
Huey-Jen Jenny Su ◽  
Pei-Chih Wu ◽  
Huan-Yao Lei ◽  
Jiu-Yao Wang
Keyword(s):  
Airborne Fungi ◽  
Total Serum ◽  
Dose Response Relationship ◽  
Total Ige ◽  
Serum Ige ◽  
Asthmatic Children ◽  
Specific Serum ◽  
Dust Mite ◽  
Der P1 ◽  
Dust Mite Allergen

We measured the number of airborne, viable fungi and house dust mite (HDM) allergen levels in the homes of a group of asthmatic children. Blood samples were drawn and the amounts of total and specific serum IgE were determined. The association between the number of fungal colonies, dust mite allergen exposure, and specific and total IgE was evaluated. The number of viable airborne fungi was high (20 543 CFU/m) in those investigated houses.Der p1concentrations on child's mattress exceeding 2μg/g were found in 78.6% of the houses. A quantitative dose-response relationship was demonstrated between the exposure to viable, airborne molds and the amount of total IgE (r=0.4399andP=.0249) and the level was further increased in children with coexposure to viable fungi and HDM.

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