Ethylene oxide-protein adduct formation in humans: influence of glutathione- S -transferase polymorphisms

1998 ◽  
Vol 71 (7) ◽  
pp. 499-502 ◽  
Author(s):  
M. Müller ◽  
A. Krämer ◽  
J. Angerer ◽  
E. Hallier
Keyword(s):  
Ethylene Oxide ◽  
Adduct Formation ◽  
Glutathione S Transferase ◽  
Protein Adduct

Probing the Paradigm of Promiscuity for N‐Heterocyclic Carbene Complexes and their Protein Adduct Formation

2021 ◽  
Author(s):  
Matthew P. Sullivan ◽  
Monika Cziferszky ◽  
Iogann Tolbatov ◽  
Dianna Truong ◽  
Davide Mercadante ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Carbene Complexes ◽  
Protein Adduct

Probing the Paradigm of Promiscuity for N‐Heterocyclic Carbene Complexes and their Protein Adduct Formation

2021 ◽  
Author(s):  
Matthew P. Sullivan ◽  
Monika Cziferszky ◽  
Iogann Tolbatov ◽  
Dianna Truong ◽  
Davide Mercadante ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Carbene Complexes ◽  
Protein Adduct

scholarly journals The effects of changes in glutathione levels through exogenous agents on intracellular cysteine content and protein adduct formation in chronic alcohol-treated VL17A cells

2016 ◽  
Vol 27 (2) ◽  
pp. 128-135 ◽  
Author(s):  
S. Mathan Kumar ◽  
Madhumitha Haridoss ◽  
Kavitha Swaminathan ◽  
Ramesh Kumar Gopal ◽  
Dahn Clemens ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Chronic Alcohol ◽  
Protein Adduct ◽  
Exogenous Agents ◽  
Cysteine Content

scholarly journals Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 446
Author(s):  
Seung-Cheol Jee ◽  
Min Kim ◽  
Kyeong Seok Kim ◽  
Hyung-Sik Kim ◽  
Jung-Suk Sung
Keyword(s):  
Phase I ◽  
Oxidative Dna Damage ◽  
Biological Activities ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Protective Effects ◽  
Glutathione S Transferase ◽  
Anti Cancer ◽  
Natural Foods ◽  
Phase I And Ii

Benzo[a]pyrene (B[a]P), a group 1 carcinogen, induces mutagenic DNA adducts. Myricetin is present in many natural foods with diverse biological activities, such as anti-oxidative and anti-cancer activities. The aim of this study was to investigate the protective effects of myricetin against B[a]P-induced toxicity. Treatment of B[a]P induced cytotoxicity on HepG2 cells, whereas co-treatment of myricetin with B[a]P reduced the formation of the B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adduct, which recovered cell viability. Furthermore, we found a protective effect of myricetin against B[a]P-induced genotoxicity in rats, via myricetin-induced inhibition of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and BPDE-DNA adduct formation in the liver, kidney, colon, and stomach tissue. This inhibition was more prominent in the liver than in other tissues. Correspondingly, myricetin regulated the phase I and II enzymes that inhibit B[a]P metabolism and B[a]P metabolites conjugated with DNA by reducing and inducing CYP1A1 and glutathione S-transferase (GST) expression, respectively. Taken together, this showed that myricetin attenuated B[a]P-induced genotoxicity via regulation of phase I and II enzymes. Our results suggest that myricetin is anti-genotoxic, and prevents oxidative DNA damage and BPDE-DNA adduct formation via regulation of phase I and II enzymes.

scholarly journals Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation

Hepatology ◽  
2015 ◽  
Vol 62 (3) ◽  
pp. 876-886 ◽  
Author(s):  
Nurdan Guldiken ◽  
Qin Zhou ◽  
Ozlem Kucukoglu ◽  
Melanie Rehm ◽  
Kateryna Levada ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Kinase Activation ◽  
Amino Terminal ◽  
Protein Adduct ◽  
Keratin 8 ◽  
Acetaminophen Hepatotoxicity

P1113 : Human Keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with JNK activation and protein adduct formation

2015 ◽  
Vol 62 ◽  
pp. S767-S768
Author(s):  
N. Guldiken ◽  
Q. Zhou ◽  
O. Kucukoglu ◽  
M. Rehm ◽  
K. Levada ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Protein Adduct ◽  
Keratin 8 ◽  
Jnk Activation ◽  
Acetaminophen Hepatotoxicity

scholarly journals CYP2D6-Mediated Mexiletine-Protein Adduct Formation

2004 ◽  
Vol 50 (1) ◽  
pp. 82-85
Author(s):  
Yoshiro Saito ◽  
Mayumi Saeki ◽  
Keiko Maekawa ◽  
Akiko Hachisuka ◽  
Reiko Teshima ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Protein Adduct
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