Effects of voluntary wheel running and amino acid supplementation on skeletal muscle of mice

2004 ◽  
Vol 93 (5-6) ◽  
pp. 655-664 ◽  
Author(s):  
Maria Antonietta Pellegrino ◽  
Lorenza Brocca ◽  
Francesco Saverio Dioguardi ◽  
Roberto Bottinelli ◽  
Giuseppe D’Antona
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Wheel Running ◽  
Amino Acid Supplementation ◽  
Voluntary Wheel Running ◽  
Acid Supplementation ◽  
Voluntary Wheel

Membrane Estrogen Receptors Regulate Voluntary Wheel Running and Contractile Function in Skeletal Muscle in Mice

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 781
Author(s):  
Jacqueline M. Crissey ◽  
J. Andries Ferreira ◽  
Dennis B. Lubahn ◽  
Marybeth Brown
Keyword(s):  
Skeletal Muscle ◽  
Estrogen Receptors ◽  
Wheel Running ◽  
Contractile Function ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

scholarly journals Voluntary Wheel Running Selectively Augments Insulin-Stimulated Vasodilation in Arterioles from White Skeletal Muscle of Insulin-Resistant Rats

2012 ◽  
Vol 19 (8) ◽  
pp. 729-738 ◽  
Author(s):  
Catherine R. Mikus ◽  
Bruno T. Roseguini ◽  
Grace M. Uptergrove ◽  
E. Matthew Morris ◽  
Randy Scott Rector ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Insulin Resistant ◽  
Voluntary Wheel

scholarly journals Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

2010 ◽  
Vol 12 (4) ◽  
pp. 362-372 ◽  
Author(s):  
Giuseppe D'Antona ◽  
Maurizio Ragni ◽  
Annalisa Cardile ◽  
Laura Tedesco ◽  
Marta Dossena ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Mitochondrial Biogenesis ◽  
Amino Acid Supplementation ◽  
Middle Aged ◽  
Acid Supplementation ◽  
Aged Mice ◽  
Branched Chain Amino Acid ◽  
Branched Chain

scholarly journals The effects of 8 weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing

2017 ◽  
Vol 220 (20) ◽  
pp. 3733-3741 ◽  
Author(s):  
Jason Tallis ◽  
Matthew F. Higgins ◽  
Frank Seebacher ◽  
Val M. Cox ◽  
Michael J. Duncan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Contractile Performance ◽  
Voluntary Wheel

scholarly journals Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats

2019 ◽  
Vol 317 (6) ◽  
pp. C1313-C1323 ◽  
Author(s):  
Matthew A. Romero ◽  
Petey W. Mumford ◽  
Paul A. Roberson ◽  
Shelby C. Osburn ◽  
Hailey A. Parry ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Dna Methylation ◽  
Exercise Training ◽  
Mrna Expression ◽  
Wheel Running ◽  
Mobile Dna ◽  
Voluntary Wheel Running ◽  
L6 Myotubes ◽  
Voluntary Wheel

Transposable elements (TEs) are mobile DNA and constitute approximately half of the human genome. LINE-1 (L1) is the only active autonomous TE in the mammalian genome and has been implicated in a number of diseases as well as aging. We have previously reported that skeletal muscle L1 expression is lower following acute and chronic exercise training in humans. Herein, we used a rodent model of voluntary wheel running to determine whether long-term exercise training affects markers of skeletal muscle L1 regulation. Selectively bred high-running female Wistar rats ( n = 11 per group) were either given access to a running wheel (EX) or not (SED) at 5 wk of age, and these conditions were maintained until 27 wk of age. Thereafter, mixed gastrocnemius tissue was harvested and analyzed for L1 mRNA expression and DNA content along with other L1 regulation markers. We observed significantly ( P < 0.05) lower L1 mRNA expression, higher L1 DNA methylation, and less L1 DNA in accessible chromatin regions in EX versus SED rats. We followed these experiments with 3-h in vitro drug treatments in L6 myotubes to mimic transient exercise-specific signaling events. The AMP-activated protein kinase (AMPK) agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR; 4 mM) significantly decreased L1 mRNA expression in L6 myotubes. However, this effect was not facilitated through increased L1 DNA methylation. Collectively, these data suggest that long-term voluntary wheel running downregulates skeletal muscle L1 mRNA, and this may occur through chromatin modifications. Enhanced AMPK signaling with repetitive exercise bouts may also decrease L1 mRNA expression, although the mechanism of action remains unknown.

Amino Acid Supplementation and Skeletal Muscle Metabolism in Ageing Populations

2006 ◽  
Vol 66 (1) ◽  
pp. 93-97
Author(s):  
Melinda Sheffield-Moore ◽  
Douglas Paddon-Jones ◽  
Randall J. Urban
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Muscle Metabolism ◽  
Amino Acid Supplementation ◽  
Acid Supplementation ◽  
Skeletal Muscle Metabolism ◽  
Ageing Populations

scholarly journals Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis

Hepatology ◽  
2015 ◽  
Vol 61 (6) ◽  
pp. 2018-2029 ◽  
Author(s):  
Cynthia Tsien ◽  
Gangarao Davuluri ◽  
Dharmvir Singh ◽  
Allawy Allawy ◽  
Gabriella A.M. Ten Have ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Alcoholic Cirrhosis ◽  
Amino Acid Supplementation ◽  
Molecular Responses ◽  
Acid Supplementation ◽  
Branched Chain Amino Acid ◽  
Branched Chain
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