scholarly journals Effect of moderate fat/high sucrose diet on glycogen synthesis rates in rat skeletal muscle upon the cessation of voluntary wheel running

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Sarah Jean Borengasser ◽  
Matthew Laye ◽  
Tyler Morris ◽  
Frank Booth ◽  
John Thyfault
2004 ◽  
Vol 92 (1-2) ◽  
pp. 90-97 ◽  
Author(s):  
Fumihiko Kariya ◽  
Hideki Yamauchi ◽  
Keizo Kobayashi ◽  
Mistuo Narusawa ◽  
Yoshibumi Nakahara

2017 ◽  
Vol 5 (6) ◽  
pp. e13207 ◽  
Author(s):  
Wenche Jørgensen ◽  
Kasper A. Rud ◽  
Ole H. Mortensen ◽  
Lis Frandsen ◽  
Niels Grunnet ◽  
...  

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 781
Author(s):  
Jacqueline M. Crissey ◽  
J. Andries Ferreira ◽  
Dennis B. Lubahn ◽  
Marybeth Brown

2012 ◽  
Vol 19 (8) ◽  
pp. 729-738 ◽  
Author(s):  
Catherine R. Mikus ◽  
Bruno T. Roseguini ◽  
Grace M. Uptergrove ◽  
E. Matthew Morris ◽  
Randy Scott Rector ◽  
...  

2017 ◽  
Vol 220 (20) ◽  
pp. 3733-3741 ◽  
Author(s):  
Jason Tallis ◽  
Matthew F. Higgins ◽  
Frank Seebacher ◽  
Val M. Cox ◽  
Michael J. Duncan ◽  
...  

2019 ◽  
Vol 317 (6) ◽  
pp. C1313-C1323 ◽  
Author(s):  
Matthew A. Romero ◽  
Petey W. Mumford ◽  
Paul A. Roberson ◽  
Shelby C. Osburn ◽  
Hailey A. Parry ◽  
...  

Transposable elements (TEs) are mobile DNA and constitute approximately half of the human genome. LINE-1 (L1) is the only active autonomous TE in the mammalian genome and has been implicated in a number of diseases as well as aging. We have previously reported that skeletal muscle L1 expression is lower following acute and chronic exercise training in humans. Herein, we used a rodent model of voluntary wheel running to determine whether long-term exercise training affects markers of skeletal muscle L1 regulation. Selectively bred high-running female Wistar rats ( n = 11 per group) were either given access to a running wheel (EX) or not (SED) at 5 wk of age, and these conditions were maintained until 27 wk of age. Thereafter, mixed gastrocnemius tissue was harvested and analyzed for L1 mRNA expression and DNA content along with other L1 regulation markers. We observed significantly ( P < 0.05) lower L1 mRNA expression, higher L1 DNA methylation, and less L1 DNA in accessible chromatin regions in EX versus SED rats. We followed these experiments with 3-h in vitro drug treatments in L6 myotubes to mimic transient exercise-specific signaling events. The AMP-activated protein kinase (AMPK) agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR; 4 mM) significantly decreased L1 mRNA expression in L6 myotubes. However, this effect was not facilitated through increased L1 DNA methylation. Collectively, these data suggest that long-term voluntary wheel running downregulates skeletal muscle L1 mRNA, and this may occur through chromatin modifications. Enhanced AMPK signaling with repetitive exercise bouts may also decrease L1 mRNA expression, although the mechanism of action remains unknown.


2004 ◽  
Vol 93 (5-6) ◽  
pp. 655-664 ◽  
Author(s):  
Maria Antonietta Pellegrino ◽  
Lorenza Brocca ◽  
Francesco Saverio Dioguardi ◽  
Roberto Bottinelli ◽  
Giuseppe D’Antona

2020 ◽  
Vol 8 (20) ◽  
Author(s):  
Angelika Schmitt ◽  
Pascal Herzog ◽  
Franziska Röchner ◽  
Anne‐Lena Brändle ◽  
Annunziata Fragasso ◽  
...  

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