Effect of prior exercise on postprandial lipemia and markers of inflammation and endothelial activation in normal weight and overweight adolescent boys

2009 ◽  
Vol 106 (5) ◽  
pp. 721-729 ◽  
Author(s):  
Owen J. MacEneaney ◽  
Michael Harrison ◽  
Donal J. O’Gorman ◽  
Elena V. Pankratieva ◽  
Paul L. O’Connor ◽  
...  
Keyword(s):  
Postprandial Lipemia ◽  
Endothelial Activation ◽  
Normal Weight ◽  
Adolescent Boys ◽  
Markers Of Inflammation ◽  
Prior Exercise ◽  
Overweight Adolescent

scholarly journals Blood-derived extracellular vesicles isolated from healthy donors exposed to air pollution modulate in vitro endothelial cells behavior

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Federica Rota ◽  
Luca Ferrari ◽  
Mirjam Hoxha ◽  
Chiara Favero ◽  
Rita Antonioli ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Extracellular Vesicles ◽  
Positive Association ◽  
Endothelial Activation ◽  
Normal Weight ◽  
Markers Of Inflammation ◽  
Healthy Donors ◽  
Increased Risk ◽  
Peripheral Cells

AbstractThe release of Extracellular Vesicles (EVs) into the bloodstream is positively associated with Particulate Matter (PM) exposure, which is involved in endothelial dysfunction and related to increased risk of cardiovascular disease. Obesity modifies the effects of PM exposure on heart rate variability and markers of inflammation, oxidative stress, and acute phase response. We isolated and characterized plasmatic EVs from six healthy donors and confirmed a positive association with PM exposure. We stratified for Body Mass Index (BMI) and observed an increased release of CD61+ (platelets) and CD105+ (endothelium) derived-EVs after high PM level exposure in Normal Weight subjects (NW) and no significant variations in Overweight subjects (OW). We then investigated the ability to activate endothelial primary cells by plasmatic EVs after both high and low PM exposure. NW-high-PM EVs showed an increased endothelial activation, measured as CD105+/CD62e+ (activated endothelium) EVs ratio. On the contrary, cells treated with OW-high-PM EVs showed reduced endothelial activation. These results suggest the ability of NW plasmatic EVs to communicate to endothelial cells and promote the crosstalk between activated endothelium and peripheral cells. However, this capacity was lost in OW subjects. Our findings contribute to elucidate the role of EVs in endothelial activation after PM exposure.

scholarly journals Evaluation of physical growth and sexual maturation rating of Adolescent boys

2012 ◽  
Vol 32 (2) ◽  
pp. 117-123
Author(s):  
DS Gedam ◽  
M Waseem ◽  
M Chansoria
Keyword(s):  
Sexual Maturation ◽  
Pubic Hair ◽  
Normal Weight ◽  
Physical Growth ◽  
Age Group ◽  
Overweight Children ◽  
Adolescent Boys ◽  
Psychological Need ◽  
Overweight Adolescent ◽  
Maturity Rating

Introduction: The present study is an attempt to evaluate the incidence of malnutrition as well as obesity. We have evaluated physical growth and sexual maturity rating of 10-18 years adolescent boys–overweight Vs Normal Vs Underweight. Material and Methods: A random sample of 530 adolescent boys (one private English Medium and one Govt. Hindi Medium School) between the ages of 10-18 years during the period of August 2008 to August 2009 constituted the material for this study. Weight, Height and BMI and Sexual maturation rating (SMR) were calculated. Results: Nearly 39% of the adolescent boys studied were either underweight (31%) or overweight (8%). All overweight adolescent boys have their mean weight more as compared to WHO 50th centile. Normal weight and underweight adolescent boys have lesser mean weight as compared to WHO 50th centile. All overweight and normal weight adolescent boys have their mean height lesser as compared to WHO 50th centile. All underweight adolescent boys except for age group of 12 yr have their mean height lesser as compared to WHO 50th centile. Underweight boys achieved different stages of genital growth prior to normal weight and overweight boys but lag behind as compared to Tanner. It was obvious that underweight boys achieved different stages of pubic hair growth prior to normal weight and overweight boys. Conclusion: Present study indicates that incidence of overweight children is also increasing significantly. Adolescent psychological need should be assessed and they should be given knowledge regarding their normal sexual growth pattern to decrease their anxiety. J. Nepal Paediatr. Soc. 32(2) 2012 117-123 doi: http://dx.doi.org/10.3126/jnps.v32i2.5601

scholarly journals Long-term Exposure to Air Pollution and Markers of Inflammation, Coagulation, and Endothelial Activation

Epidemiology ◽  
2015 ◽  
Vol 26 (3) ◽  
pp. 310-320 ◽  
Author(s):  
Anjum Hajat ◽  
Matthew Allison ◽  
Ana V. Diez-Roux ◽  
Nancy Swords Jenny ◽  
Neal W. Jorgensen ◽  
...  
Keyword(s):  
Air Pollution ◽  
Endothelial Activation ◽  
Markers Of Inflammation

scholarly journals The Effects of Circuit Resistance Training on Inflammatory Status, Insulin Resistance and Body Composition in Overweight Adolescent Boys

2020 ◽  
Author(s):  
Hamid Alizadeh ◽  
Alireza Safarzade ◽  
Elahe Talebi-Garakani
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Resistance Training ◽  
P Value ◽  
Daily Routine ◽  
Adolescent Boys ◽  
Inflammatory Status ◽  
Overweight Adolescent ◽  
Circuit Resistance Training ◽  
Circuit Resistance

Objective: The overweight-related health problems among adolescents are obvious. Resistance training is recognized as a safe and efficacious exercise modality to have health-promoting effects in overweight adolescents. This study aimed to assess the efficacy of circuit resistance training (CRT) in improving inflammatory status, insulin resistance and body composition in overweight male adolescents. Materials and Methods: Twenty overweight adolescent boys (aged: 18.5 (±1), weight: 81.1 (±4.5), body mass index: 27.7 (±0.7)) completed this study. The participants were randomly and equally divided into two groups of control (CG; n=10) and circuit resistance training (CRT; n=10). The CG did their daily routine activities and the CRT group performed its training protocol 3 days a week for 6 weeks. Body composition components and serum variables were measured a day before and after the study. Insulin resistance index was measured by HOMA-IR. Results: The subjects in the CG showed significantly increased changes compared with pre-training values. Moreover, significant changes were found fort the changes of BW ( P -value= 0.005), BMI ( P -value= 0.001) and BF% ( P -value= 0.003) between groups. Conclusion: This study suggested that although six weeks of CRT failed to induce meaningful anti-inflammatory cytokine responses, and to improve body composition and HOMA-IR in overweight adolescent boys, but had protective effects on inflammatory status, HOMA-IR and body composition and prevented them from being deteriorated

scholarly journals Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients

Stroke ◽  
2021 ◽  
Author(s):  
Lindsay S. McAlpine ◽  
Adeel S. Zubair ◽  
Ilavarasy Maran ◽  
Pola Chojecka ◽  
Paul Lleva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Endothelial Activation ◽  
Vascular Risk Factors ◽  
Interquartile Range ◽  
Stroke Onset ◽  
Vascular Risk ◽  
Stroke Patients ◽  
Markers Of Inflammation ◽  
Von Willebrand

Background and Purpose: Reports indicate an increased risk of ischemic stroke during coronavirus disease 2019 (COVID-19) infection. We aimed to identify patients with COVID-19 and ischemic stroke and explore markers of inflammation, hypercoagulability, and endotheliopathy, a structural and functional disturbance of the vascular endothelium due to a stressor. Methods: This was a retrospective, observational cohort study comparing acute ischemic stroke patients with and without COVID-19 across 3 hospitals. Timing of stroke onset during COVID-19 course and markers of inflammation, hypercoagulability, and endothelial activation were evaluated by COVID-19 status and stroke cause. Results: Twenty-one patients with ischemic stroke were diagnosed with COVID-19 during the study period. Patients with COVID-19 had a similar age and burden of vascular risk factors compared with the control cohort (n=168). We identified a temporal correlation between stroke onset and the peak of acute phase reactants, including CRP (C-reactive protein), ferritin, and d-dimer. In subsets of patients with labs available, embolic stroke of undetermined source was associated with elevated IL (interleukin)-6 (median, 171 [interquartile range, 13–375] versus 8 [4–11], P <0.01) and sIL (soluble IL)-2 receptor (1972 [1525–4720] versus 767 [563–1408.5], P =0.05) levels. Stroke patients with COVID-19 demonstrated elevated levels of endothelial activation markers compared with non-COVID-19 stroke controls (median von Willebrand activity 285.0% [interquartile range, 234%–382%] versus 150% [128%–183%], P =0.034; von Willebrand antigen 330.0% [265%–650%] versus 152% [130%–277%], P =0.007, and factor VIII 301% [289%–402%] versus 49% [26%–94%], P <0.001). Conclusions: Ischemic stroke in patients with COVID-19 is associated with endotheliopathy and a systemic inflammatory response in patients with vascular risk factors. Further research evaluating endothelial and inflammatory markers in the setting of ischemic stroke and COVID-19 in larger, prospective cohorts is needed to validate the findings.

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