scholarly journals Atrophy of calf muscles by unloading results in an increase of tissue sodium concentration and fat fraction decrease: a 23Na MRI physiology study

2017 ◽  
Vol 117 (8) ◽  
pp. 1585-1595 ◽  
Author(s):  
D. A. Gerlach ◽  
K. Schopen ◽  
P. Linz ◽  
B. Johannes ◽  
J. Titze ◽  
...  
Keyword(s):  
Sodium Concentration ◽  
Fat Fraction ◽  
Tissue Sodium ◽  
23Na Mri ◽  
Calf Muscles

SO027ASSOCIATIONS OF MUSCLE SODIUM DEPOSITION WITH SODIUM-23 MRI IN HEMODIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Fabio Salerno ◽  
Alireza Akbari ◽  
Sandrine Lemoine ◽  
Justin Dorie ◽  
Tanya Tamasi ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Clinical Outcomes ◽  
Soleus Muscle ◽  
Patient Population ◽  
Region Of Interest ◽  
Strong Relationship ◽  
Sodium Concentration ◽  
Strong Negative Correlation ◽  
Tissue Sodium ◽  
23Na Mri

Abstract Background and Aims The development of sodium-23 magnetic resonance imaging (23Na MRI) allows the clinical quantification of tissue sodium. Recent studies have shown that hemodialysis (HD) patients have a tendency to retain tissue sodium due to impaired mechanisms in local tissue sodium clearance. However, the clinical significance of tissue sodium deposition in the HD patient population is unclear yet. The aim of this study was to investigate the association of tissue sodium deposition with well-established biomarkers of clinical outcomes. Method Chronic, thrice weekly HD patients underwent 23Na MRI of the leg on a non-dialysis day, during either the long or short interdialytic interval. Blood samples were also taken for the measurement of standard blood-based biomarkers. A multinuclear-capable 3.0-T MRI (GE Healthcare, Milwaukee WI) was used to acquire proton and sodium images. Maps of tissue 23Na concentration were generated using an in-house software developed within MATLAB (Mathworks, Natick, USA, R2018a). 23Na concentration maps were superimposed with the proton-anatomy images to delineate the regions of interest. Using the Horos (The Horos Project, Version 4.0.0) software, the soleus muscle was segmented (Figure, Panel A) and the sodium concentration in the region of interest was recorded for analysis. Results 28 HD patients completed both 23Na MRI and bloodwork; 7/28 (25%) patients were females; mean±SD age was 66.1±8.3 years, mean body mass index was 30.9±6.5 kg/m2, and mean HD vintage was 30.2±34.9 months. Soleus muscle sodium concentration showed a strong, negative correlation with serum albumin (Figure, Panel B; r=-0.66, p<0.0001). Furthermore, soleus muscle sodium concentration showed a minor association with plasma hemoglobin (r=-0.46, p=0.01). Conclusion Serum albumin is a recognized, powerful predictor of mortality in the hemodialysis patient population. The strong relationship between muscle sodium concentration and serum albumin levels suggests that tissue sodium deposition may be a relevant biomarker of clinical outcomes. In addition, muscle sodium deposition may be involved in the development of anemia. These findings warrant further studies investigating the consequences of sodium removal on these biomarkers.

Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI

2007 ◽  
Vol 106 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Ronald Ouwerkerk ◽  
Michael A. Jacobs ◽  
Katarzyna J. Macura ◽  
Antonio C. Wolff ◽  
Vered Stearns ◽  
...  
Keyword(s):  
Sodium Concentration ◽  
Breast Lesions ◽  
Non Invasive ◽  
Malignant Breast ◽  
Tissue Sodium ◽  
23Na Mri

Tissue Sodium Concentration within White Matter Correlates with the Extent of Small Vessel Disease

2021 ◽  
pp. 1-9
Author(s):  
Anne Adlung ◽  
Melina Samartzi ◽  
Lothar R. Schad ◽  
Eva Neumaier-Probst ◽  
Marc Fatar ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
White Matter ◽  
Acute Ischemic Stroke ◽  
Small Vessel Disease ◽  
Sodium Concentration ◽  
Small Vessel ◽  
Vessel Disease ◽  
Significant Difference ◽  
Tissue Sodium ◽  
23Na Mri

Introduction: Sodium MRI (23Na MRI) derived biomarkers such as tissue sodium concentration (TSC) provide valuable information on cell function and brain tissue viability and has become a reliable tool for the assessment of brain tumors and ischemic stroke beyond pathoanatomical morphology. Patients with major stroke often suffer from different degrees of underlying white matter lesions (WMLs) attributed to chronic small vessel disease. This study aimed to evaluate the WM TSC in patients with an acute ischemic stroke and to correlate the TSC with the extent of small vessel disease. Furthermore, the reliability of relative TSC (rTSC) compared to absolute TSC in these patients was analyzed. Methodology: We prospectively examined 62 patients with acute ischemic stroke (73 ± 13 years) between November 2016 and August 2019 from which 18 patients were excluded and thus 44 patients were evaluated. A 3D 23Na MRI was acquired in addition to a T2-TIRM and a diffusion-weighted image. Coregistration and segmentation were performed with SPM 12 based on the T2-TIRM image. The extension of WM T2 hyperintense lesions in each patient was classified using the Fazekas scale of WMLs. The absolute TSC in the WM region was correlated to the Fazekas grades. The stroke region was manually segmented on the coregistered absolute diffusion coefficient image and absolute, and rTSC was calculated in the stroke region and compared to nonischemic WM region. Statistical significance was evaluated using the Student t-test. Results: For patients with Fazekas grade I (n = 25, age: 68.5 ± 15.1 years), mean TSC in WM was 55.57 ± 7.43 mM, and it was not statistically significant different from patients with Fazekas grade II (n = 7, age: 77.9 ± 6.4 years) with a mean TSC in WM of 53.9 ± 6.4 mM, p = 0.58. For patients with Fazekas grade III (n = 9, age: 81.4 ± 7.9 years), mean TSC in WM was 68.7 ± 10.5 mM, which is statistically significantly higher than the TSC in patients with Fazekas grade I and II (p < 0.001 and p = 0.05, respectively). There was a positive correlation between the TSC in WM and the Fazekas grade with r = 0.48 p < 0.001. The rTSC in the stroke region was statistically significant difference between low (0 and I) and high (2 and 3) Fazekas grades (p = 0.0353) whereas there was no statistically significant difference in absolute TSC in the stroke region between low (0 and I) and high (2 and 3) Fazekas grades. Conclusion: The significant difference in absolute TSC in WM in patients with severe small vessel disease; Fazekas grade 3 can lead to inaccuracies using rTSC quantification for evaluation of acute ischemic stroke using 23 Na MRI. The study, therefore, emphasizes the importance of absolute tissue sodium quantification.

Assessment of Tissue Sodium Content by 23Na-MRI in Patients with Adrenal Insufficiency - a Pilot Study

2018 ◽  
Author(s):  
Andreas Weng ◽  
Stephanie Burger-Stritt ◽  
Irina Chifu ◽  
Martin Christa ◽  
Bernhard Petritsch ◽  
...  
Keyword(s):  
Pilot Study ◽  
Adrenal Insufficiency ◽  
Sodium Content ◽  
Tissue Sodium ◽  
23Na Mri

scholarly journals Effects of Tissue Sodium Storage on Plasma Sodium Concentration in Response to Hypo- and Hypertonic Stimuli

Nephron ◽  
2021 ◽  
pp. 1-3
Author(s):  
Rosa D. Wouda ◽  
Rik H.G. Olde Engberink ◽  
Eliane F.E. Wenstedt ◽  
Jetta J. Oppelaar ◽  
Liffert Vogt
Keyword(s):  
Sodium Concentration ◽  
Plasma Sodium ◽  
Plasma Sodium Concentration ◽  
Sodium Storage ◽  
Tissue Sodium

scholarly journals Tissue sodium concentration and sodium T1 mapping of the human brain at 3 T using a Variable Flip Angle method

2019 ◽  
Vol 58 ◽  
pp. 116-124 ◽  
Author(s):  
Arthur Coste ◽  
Fawzi Boumezbeur ◽  
Alexandre Vignaud ◽  
Guillaume Madelin ◽  
Kathrin Reetz ◽  
...  
Keyword(s):  
Human Brain ◽  
T1 Mapping ◽  
Sodium Concentration ◽  
Flip Angle ◽  
Variable Flip Angle ◽  
Angle Method ◽  
Tissue Sodium

P4993Tissue sodium concentration emerged as a determinant of hypertrophic vascular remodeling in type 2 diabetes

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
R Schmieder ◽  
S Jung ◽  
D Kannenkeril ◽  
J M Harazny ◽  
K Striepe ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Remodeling ◽  
Sodium Intake ◽  
Structural Parameters ◽  
Sodium Concentration ◽  
Sodium Content ◽  
Resistance Vessels ◽  
Retinal Arterioles ◽  
Tissue Sodium

Abstract Background Studies describe a linkage between greater sodium intake and higher incidence of organ damage and cardiovascular end points. Sodium intake is usually assessed by measuring 24-hour urinary sodium excretion, which is prone to high fluctuation. For the assessment of tissue sodium a new technique (23Na-MRI) has been developed. We analyzed whether tissue sodium is linked to vascular remodeling of small resistance vessels in patients with type-2 diabetes. Methods In patients with type 2 diabetes we assessed tissue sodium content and vascular structural parameters of the retinal arterioles, since structural changes of resistance vessels (150–300 μm) can be non-invasively and reliably assessed in the retinal circulation by Scanning Laser Doppler Flowmetry (SLDF). Patients with antidiabetic medication were off the therapy (antihypertensives were kept constant) for 4 weeks. The structural parameters of retinal arterioles assessed were outer- and inner diameter (OD & ID), wall thickness (WT), wall-to-lumen ratio (WLR) and wall cross sectional area (WCSA). Tissue sodium content was assessed non-invasively with a 3.0 T clinical MRI system in each patient. Subject placed their lower legs in the center of a 23Na knee coil and sodium content in skin and muscle (musculus triceps surae) were measured. Results In patients with type 2 diabetes (N=52) we observed a significant correlation between tissue sodium content (muscle and skin) and OD, WT and WCSA and a trend has been noticed between muscle sodium content and ID and WLR. Multiple linear regression analysis demonstrated that tissue sodium content is a significant determinant of hypertrophic vascular remodeling as indicated by increased WT and WCSA, independent of age, gender and 24-hour ambulatory diastolic blood pressure. Correlation coefficients Muscle sodium content (mmol/l) Skin sodium content (mmol/l) OD (μmol) r=0.402, p=0.003 r=0.299, p=0.033 ID (μmol) r=0.265, p=0.058 r=0.202, p=0.154 WT (μm) r=0.402, p=0.003 r=0.313, p=0.026 WLR r=0.247, p=0.078 r=0.171, p=0.230 WCSA (μm2) r=0.417, p=0.002 r=0.322, p=0.021 Conclusion With the novel 23Na-MRI technology, we could demonstrate that high tissue sodium concentration is linked to with hypertrophic vascular remodeling of retinal arterioles. Thus, the reduction of tissue sodium content may emerge as a therapeutic target.

scholarly journals Sodium-23 Magnetic Resonance Imaging Has Potential for Improving Penumbra Detection but Not for Estimating Stroke Onset Time

2014 ◽  
Vol 35 (1) ◽  
pp. 103-110 ◽  
Author(s):  
Friedrich Wetterling ◽  
Lindsay Gallagher ◽  
Jim Mullin ◽  
William M Holmes ◽  
Chris McCabe ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Onset Time ◽  
Sodium Concentration ◽  
Artery Occlusion ◽  
Stroke Onset ◽  
Resonance Imaging ◽  
Sodium Mri ◽  
The Core ◽  
Tissue Sodium

Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, multinuclear hydrogen-1/sodium-23 magnetic resonance imaging (MRI) was used to measure the changing sodium signal and hydrogen-apparent diffusion coefficient (ADC) in the ischemic core and penumbra after rat middle cerebral artery occlusion (MCAO). Penumbra and core were defined from perfusion imaging and histologically defined irreversibly damaged tissue. The sodium signal in the core increased linearly with time, whereas the ADC rapidly decreased by >30% within 20 minutes of stroke onset, with very little change thereafter (0.5–6 hours after MCAO). Previous reports suggest that the time point at which tissue sodium signal starts to rise above normal (onset of elevated tissue sodium, OETS) represents stroke onset time (SOT). However, extrapolating core data back in time resulted in a delay of 72±24 minutes in OETS compared with actual SOT. At the OETS in the core, penumbra sodium signal was significantly decreased (88±6%, P=0.0008), whereas penumbra ADC was not significantly different (92±18%, P=0.2) from contralateral tissue. In conclusion, reduced sodium-MRI signal may serve as a viability marker for penumbra detection and can complement hydrogen ADC and perfusion MRI in the time-independent assessment of tissue fate in acute stroke patients.

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