Assessment of Tissue Sodium Content by 23Na-MRI in Patients with Adrenal Insufficiency - a Pilot Study

2018 ◽  
Author(s):  
Andreas Weng ◽  
Stephanie Burger-Stritt ◽  
Irina Chifu ◽  
Martin Christa ◽  
Bernhard Petritsch ◽  
...  
Keyword(s):  
Pilot Study ◽  
Adrenal Insufficiency ◽  
Sodium Content ◽  
Tissue Sodium ◽  
23Na Mri

scholarly journals Tissue Sodium Content and Arterial Hypertension in Obese Adolescents

2019 ◽  
Vol 8 (12) ◽  
pp. 2036
Author(s):  
Sophie Roth ◽  
Lajos Markó ◽  
Anna Birukov ◽  
Anja Hennemuth ◽  
Peter Kühnen ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Transition To Adulthood ◽  
Sodium Content ◽  
Triceps Surae ◽  
Obese Patients ◽  
Obese Adolescents ◽  
Tissue Sodium ◽  
23Na Mri

Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and hypertension have been observed in adults. We aimed to investigate these associations in adolescents. A cohort of 32 adolescents (13–17 years), comprising 20 obese patients, of whom 11 were hypertensive, as well as 12 age-matched controls, underwent 23Na-MRI of the left lower leg with a standard clinical 3T scanner. Median triceps surae muscle Na+ content in hypertensive obese (11.95 mmol/L [interquartile range 11.62–13.66]) was significantly lower than in normotensive obese (13.63 mmol/L [12.97–17.64]; p = 0.043) or controls (15.37 mmol/L [14.12–16.08]; p = 0.012). No significant differences were found between normotensive obese and controls. Skin Na+ content in hypertensive obese (13.33 mmol/L [11.53–14.22] did not differ to normotensive obese (14.12 mmol/L [13.15–15.83]) or controls (11.48 mmol/L [10.48–12.80]), whereas normotensive obese had higher values compared to controls (p = 0.004). Arterial hypertension in obese adolescents is associated with low muscle Na+ content. These findings suggest an early dysregulation of Na+ homeostasis in cardiometabolic disease. Further research is needed to determine whether this association is causal and how it evolves in the transition to adulthood.

scholarly journals SAT-386 Assessment Of Tissue Sodium Content By23Na-MRI In Patients With Adrenal Insufficiency

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Irina Chifu ◽  
Andreas Weng ◽  
Stephanie Burger-Stritt ◽  
Martin Christa ◽  
Bernhard Petritsch ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Sodium Content ◽  
Tissue Sodium

P4993Tissue sodium concentration emerged as a determinant of hypertrophic vascular remodeling in type 2 diabetes

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
R Schmieder ◽  
S Jung ◽  
D Kannenkeril ◽  
J M Harazny ◽  
K Striepe ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Remodeling ◽  
Sodium Intake ◽  
Structural Parameters ◽  
Sodium Concentration ◽  
Sodium Content ◽  
Resistance Vessels ◽  
Retinal Arterioles ◽  
Tissue Sodium

Abstract Background Studies describe a linkage between greater sodium intake and higher incidence of organ damage and cardiovascular end points. Sodium intake is usually assessed by measuring 24-hour urinary sodium excretion, which is prone to high fluctuation. For the assessment of tissue sodium a new technique (23Na-MRI) has been developed. We analyzed whether tissue sodium is linked to vascular remodeling of small resistance vessels in patients with type-2 diabetes. Methods In patients with type 2 diabetes we assessed tissue sodium content and vascular structural parameters of the retinal arterioles, since structural changes of resistance vessels (150–300 μm) can be non-invasively and reliably assessed in the retinal circulation by Scanning Laser Doppler Flowmetry (SLDF). Patients with antidiabetic medication were off the therapy (antihypertensives were kept constant) for 4 weeks. The structural parameters of retinal arterioles assessed were outer- and inner diameter (OD & ID), wall thickness (WT), wall-to-lumen ratio (WLR) and wall cross sectional area (WCSA). Tissue sodium content was assessed non-invasively with a 3.0 T clinical MRI system in each patient. Subject placed their lower legs in the center of a 23Na knee coil and sodium content in skin and muscle (musculus triceps surae) were measured. Results In patients with type 2 diabetes (N=52) we observed a significant correlation between tissue sodium content (muscle and skin) and OD, WT and WCSA and a trend has been noticed between muscle sodium content and ID and WLR. Multiple linear regression analysis demonstrated that tissue sodium content is a significant determinant of hypertrophic vascular remodeling as indicated by increased WT and WCSA, independent of age, gender and 24-hour ambulatory diastolic blood pressure. Correlation coefficients Muscle sodium content (mmol/l) Skin sodium content (mmol/l) OD (μmol) r=0.402, p=0.003 r=0.299, p=0.033 ID (μmol) r=0.265, p=0.058 r=0.202, p=0.154 WT (μm) r=0.402, p=0.003 r=0.313, p=0.026 WLR r=0.247, p=0.078 r=0.171, p=0.230 WCSA (μm2) r=0.417, p=0.002 r=0.322, p=0.021 Conclusion With the novel 23Na-MRI technology, we could demonstrate that high tissue sodium concentration is linked to with hypertrophic vascular remodeling of retinal arterioles. Thus, the reduction of tissue sodium content may emerge as a therapeutic target.

scholarly journals Atrophy of calf muscles by unloading results in an increase of tissue sodium concentration and fat fraction decrease: a 23Na MRI physiology study

2017 ◽  
Vol 117 (8) ◽  
pp. 1585-1595 ◽  
Author(s):  
D. A. Gerlach ◽  
K. Schopen ◽  
P. Linz ◽  
B. Johannes ◽  
J. Titze ◽  
...  
Keyword(s):  
Sodium Concentration ◽  
Fat Fraction ◽  
Tissue Sodium ◽  
23Na Mri ◽  
Calf Muscles

scholarly journals Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

Obesity ◽  
2017 ◽  
Vol 26 (2) ◽  
pp. 310-317 ◽  
Author(s):  
Rachelle Crescenzi ◽  
Adriana Marton ◽  
Paula M.C. Donahue ◽  
Helen B. Mahany ◽  
Sarah K. Lants ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Sodium Content ◽  
Subcutaneous Adipose ◽  
Tissue Sodium

scholarly journals Optimizing the Calcium Content of a Copolymer Acrylamide Gel Matrix for Dark-grown Seedlings

1998 ◽  
Vol 123 (6) ◽  
pp. 1107-1111
Author(s):  
Patricia Newton Myers ◽  
Cary A. Mitchell
Keyword(s):  
Calcium Content ◽  
Sodium Content ◽  
Elongation Rate ◽  
Normal Plant ◽  
Short Term ◽  
Soybean Seedlings ◽  
Good Potential ◽  
Hypocotyl Tissue ◽  
Water Holding ◽  
Tissue Sodium

A copolymer acrylamide acrylate gel was investigated as the sole root matrix for dark-grown seedlings of soybean (Glycine max Merr. `Century 84'). Increasing Ca2+ in the hydrating solution of the hydrogel from 1 to 10 mm decreased its water-holding capacity from 97 to 46 mL·g-1, yet water potential of the medium remained high, sufficient for normal plant growth at all Ca2+ concentrations tested. Elongation rate of dark-grown soybean seedlings over a 54-hour period was 0.9, 1.5, and 1.8 mm·h-1 with 1.0, 2.5, or 5.0 mm Ca2+, respectively, but did not increase with further increases in Ca2+ concentration. Further study revealed that Na+ was released from the hydrogel medium and was taken up by the seedlings as Ca2+ increased in the medium. In dry hypocotyl tissue, sodium content correlated negatively with calcium content. Despite the presence of Na+ in the hydrogel, seedling growth was normal when adequate Ca2+ was added in the hydrating solution. Acrylamide hydrogels hold good potential as a sole growth matrix for short-term experiments with dark-grown seedlings without irrigation.

Examining the Use of Taste Enhancers in Instant Noodles and Public Perception of Monosodium Glutamate in Muscat, Oman

2020 ◽  
Vol 16 (2) ◽  
pp. 198-206
Author(s):  
Maryam Al-Azawi ◽  
Dima Altattan ◽  
Salma Khamis Ali ◽  
Majed Mamoun AbuKhader
Keyword(s):  
Pilot Study ◽  
Food Industry ◽  
Public Perception ◽  
Fruits And Vegetables ◽  
Monosodium Glutamate ◽  
Food Additives ◽  
Sodium Content ◽  
Large Numbers ◽  
The Media ◽  
Instant Noodles

Background: Monosodium Glutamate (MSG) is an extensively used additive in food industry as a taste enhancer and found naturally in fruits and vegetables. Aim: To examine and assess the use of taste enhancers and correlate with the amount of salt (sodium) in instant noodles sold in the Omani market. A pilot study was also conducted to assess public perception towards MSG use in these products. Methods: The different names and written forms of taste enhancers and salt (sodium) content are printed on the outer pack of instant noodles and 200 questionnaires distributed to public were recorded, collected respectively and subsequently analyzed. Results: There were 93 instant noodles varieties collected in which MSG was either not used (27.8%) or used alone (32.3%) or with other additives (39.9%). Three popular brands; Indomie (14 varieties), Maggie (9 varieties) and Koka (18 varieties), were considered for further examination for the number of food additives used and the correlation between MSG and salt (sodium) content. One of these brands has a significant amount of food additives used and in these products there is a tendency (p = 0.051) that the use of MSG is associated with reducing the amount of salt (sodium) content. The survey showed that public perception towards MSG is better among Asians. Noodles are popular among participants despite the awareness of the presence of MSG. Conclusion: Large numbers of noodles products contain MSG in addition to other additives. It seems that consumption of instant noodles is influenced by the culture or the media or the surrounding.

EFFECT OF SODIUM RESTRICTION AND EXPERIMENTAL NEPHROSIS ON TISSUE SPACES AND TISSUE SODIUM DISTRIBUTION IN THE RAT

1962 ◽  
Vol 25 (3) ◽  
pp. 323-330 ◽  
Author(s):  
P. J. LEONARD
Keyword(s):  
Sodium Content ◽  
Abdominal Muscle ◽  
Normal Diet ◽  
Absolute Amount ◽  
Total Water ◽  
Aldosterone Secretion ◽  
Tissue Water ◽  
Extracellular Sodium ◽  
Total Tissue ◽  
Tissue Sodium

SUMMARY Aldosterone secretion is increased in rats on a diet low in sodium content or in rats with nephrosis induced by administration of an aminonucleoside. Distributions of water and sodium in heart, liver, adrenals and abdominal muscle were compared in nephrotic rats, sodium-restricted rats and rats maintained on a normal diet. In nephrotic animals total tissue sodium increased significantly in liver, heart and abdominal muscle and was associated with increased intracellular sodium (both absolute amount and concentration) in these tissues as well as in the adrenals; extracellular sodium decreased in heart and adrenals and increased in abdominal muscle. In nephrotic rats increased total tissue water in liver and abdominal muscle was associated with increased extracellular water while increased total water in adrenals was accompanied by increased intracellular water. The results in sodium-restricted rats were similar to those in nephrotic rats except that no changes were found in abdominal muscle and that water content of liver was unchanged.

scholarly journals Determination of iodine and sodium content in fermented meat products purchased in the Czech Republic– a pilot study

2014 ◽  
Vol 83 (3) ◽  
pp. 273-277 ◽  
Author(s):  
Pavla Steinhauserová ◽  
Irena Řehůřková ◽  
Jiří Ruprich
Keyword(s):  
Czech Republic ◽  
Pilot Study ◽  
Sodium Intake ◽  
Meat Products ◽  
Sodium Content ◽  
European Countries ◽  
Meat Production ◽  
Global Public Health ◽  
The Czech Republic ◽  
High Sodium

Iodine deficiency is still one of acute global public health problems. The best strategy to ensure its required amount in human population is salt fortification with potassium iodate or iodide. Food industry plays an important role in supporting good health status of consumers. Using iodized salt in meat production is not mandatory in the Czech Republic. The aim of this pilot study was to evaluate a group of salty meat products - fermented meats purchased in the Czech Republic in terms of iodine and sodium content. Totally 36 samples purchased in 9 major retail chains, produced in 9 different European countries were analyzed by spectrophotometric methods. As the results show, the use of iodinated salt was obvious only among Czech producers. The application of iodinated and marine salt does not mean that those products are a good source of iodine. Consumers should be more informed about iodine and sodium content in food. They should also be more aware about the health impact of high sodium intake. This pilot study compares iodine and sodium content in this type of meat products produced in different European countries but purchased in the Czech Republic.

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