Epithelial to mesenchymal transition in cutaneous squamous cell carcinoma is correlated with COX-2 expression but not with the presence of stromal macrophages or CD10-expressing cells

2012 ◽  
Vol 460 (5) ◽  
pp. 481-487 ◽  
Author(s):  
Tae Jung Jang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Mesenchymal Transition ◽  
Cox 2

MicroRNA-200c Prevents Progress of Cutaneous Squamous Cell Carcinoma by Targeting Tyrosine-Protein Kinase Fyn (FYN)

2021 ◽  
Vol 11 (5) ◽  
pp. 886-895
Author(s):  
Jie Yang ◽  
Jianji Wan ◽  
Xiuqin Dong ◽  
Liehua Deng
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Cellular Growth ◽  
Skin Tumor ◽  
Promoting Effect ◽  
Mesenchymal Transition ◽  
Malignant Skin

Cutaneous squamous cell carcinoma (cSCC), a malignant skin tumor, begins in the epidermis and the keratinocytes of the skin appendages. However, the cause remains unclear. MicroRNA-200c (miR-200c), a key modulator of epithelial-to-mesenchymal transition (EMT), has been reported to act as an anticancer gene in a variety of cancers. However, its role and partial mechanism in cSCC remain undetermined. The results of this study showed depleted levels of miR-200c in cSCC tissues. Its suppressive effects on cell proliferation, and motility, as well as its apoptosis-promoting effect, were observed in the A-431 cells. Additionally, immunofluorescence and qRT-PCR assays revealed that FYN acted as a direct target of miR-200c, and FYN knockdown exerted had similar impact as that of miR-200c overexpression, including increased cellular apoptosis and decreased cellular growth. These results emphasized the onco-suppressive nature of miR-200c, which was evident based on its interaction with FYN in cSCC. This finding could have potential benefits in developing cSCC therapy.

scholarly journals Markers of Epithelial to Mesenchymal Transition in Association with Survival in Head and Neck Squamous Cell Carcinoma (HNSCC)

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94273 ◽  
Author(s):  
Eirini Pectasides ◽  
Theodoros Rampias ◽  
Clarence Sasaki ◽  
Christos Perisanidis ◽  
Vassilis Kouloulias ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Neck Squamous Cell Carcinoma ◽  
Mesenchymal Transition
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