scholarly journals Abstract 1540: Cutaneous squamous cell carcinoma: Evidence of epithelial to mesenchymal transition

2020 ◽  
Author(s):  
Christopher S. Pulford ◽  
Chandana K. Uppalapati ◽  
Elizabeth E. Hull ◽  
Kathryn J. Leyva
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Mesenchymal Transition

MicroRNA-200c Prevents Progress of Cutaneous Squamous Cell Carcinoma by Targeting Tyrosine-Protein Kinase Fyn (FYN)

2021 ◽  
Vol 11 (5) ◽  
pp. 886-895
Author(s):  
Jie Yang ◽  
Jianji Wan ◽  
Xiuqin Dong ◽  
Liehua Deng
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Cellular Growth ◽  
Skin Tumor ◽  
Promoting Effect ◽  
Mesenchymal Transition ◽  
Malignant Skin

Cutaneous squamous cell carcinoma (cSCC), a malignant skin tumor, begins in the epidermis and the keratinocytes of the skin appendages. However, the cause remains unclear. MicroRNA-200c (miR-200c), a key modulator of epithelial-to-mesenchymal transition (EMT), has been reported to act as an anticancer gene in a variety of cancers. However, its role and partial mechanism in cSCC remain undetermined. The results of this study showed depleted levels of miR-200c in cSCC tissues. Its suppressive effects on cell proliferation, and motility, as well as its apoptosis-promoting effect, were observed in the A-431 cells. Additionally, immunofluorescence and qRT-PCR assays revealed that FYN acted as a direct target of miR-200c, and FYN knockdown exerted had similar impact as that of miR-200c overexpression, including increased cellular apoptosis and decreased cellular growth. These results emphasized the onco-suppressive nature of miR-200c, which was evident based on its interaction with FYN in cSCC. This finding could have potential benefits in developing cSCC therapy.

scholarly journals Markers of Epithelial to Mesenchymal Transition in Association with Survival in Head and Neck Squamous Cell Carcinoma (HNSCC)

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94273 ◽  
Author(s):  
Eirini Pectasides ◽  
Theodoros Rampias ◽  
Clarence Sasaki ◽  
Christos Perisanidis ◽  
Vassilis Kouloulias ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Neck Squamous Cell Carcinoma ◽  
Mesenchymal Transition

scholarly journals Extracellular Vesicle-Mediated Chemoresistance in Oral Squamous Cell Carcinoma

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhu-Jun Law ◽  
Xin Hui Khoo ◽  
Pei Tee Lim ◽  
Bey Hing Goh ◽  
Long Chiau Ming ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Treatment Options ◽  
Extracellular Vesicle ◽  
High Recurrence Rate ◽  
Mesenchymal Transition ◽  
Persistent Problem

Oral Squamous Cell Carcinoma (OSCC) remains a cancer with poor prognosis and high recurrence rate. Even with multimodal treatment options available for OSCC, tumor drug resistance is still a persistent problem, leading to increased tumor invasiveness among OSCC patients. An emerging trend of thought proposes that extracellular vesicles (EVs) play a role in facilitating tumor progression and chemoresistance via signaling between tumor cells. In particular, exosomes and microvesicles are heavily implicated in this process by various studies. Where primary studies into a particular EV-mediated chemoresistance mechanism in OSCC are limited, similar studies on other cancer cell types will be used in the discussion below to provide ideas for a new line of investigation into OSCC chemoresistance. By understanding how EVs are or may be involved in OSCC chemoresistance, novel targeted therapies such as EV inhibition may be an effective alternative to current treatment options in the near future. In this review, the current understandings on OSCC drug mechanisms under the novel context of exosomes and microvesicles were reviewed, including shuttling of miRNA content, drug efflux, alteration of vesicular pH, anti-apoptotic signaling, modulation of DNA damage repair, immunomodulation, epithelial-to-mesenchymal transition and maintenance of tumor by cancer stem cells.

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