scholarly journals Morphologic and molecular classification of lung neuroendocrine neoplasms

2021 ◽  
Author(s):  
Jasna Metovic ◽  
Marco Barella ◽  
Fabrizio Bianchi ◽  
Paul Hofman ◽  
Veronique Hofman ◽  
...  
Keyword(s):  
Natural History ◽  
Large Cell ◽  
Molecular Classification ◽  
Biological Data ◽  
Neuroendocrine Neoplasms ◽  
History Of Disease ◽  
History Of ◽  
Biological Determinants ◽  
Unsupervised Approach

AbstractNeuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs) composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) inclusive of large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma (SCLC). NETs and NECs are thought to represent distinct and separate lesions with neither molecular overlap nor common developmental continuum. Two perspectives were addressed regarding the morphologic and molecular classification of lung NENs: (i) a supervised approach by browsing the traditional classification, the relevant gene alterations, and their clinical implications; and (ii) an unsupervised approach, by reappraising neoplasms according to risk factors and natural history of disease to construct an interpretation model relied on biological data. We herein emphasize lights and shadows of the current classification of lung NENs and provide an alternative outlook on these tumors focused on what we currently know about the biological determinants and the natural history of disease.

scholarly journals REVIEW ON THE CONCEPT OF SHAT KRIYAKALA

2022 ◽  
Vol 12 (6) ◽  
pp. 56-60
Author(s):  
Anu P Baby ◽  
Jigeesh PP
Keyword(s):  
Natural History ◽  
Early Stage ◽  
Disease Process ◽  
Pathological Process ◽  
Stage Of Development ◽  
Long Run ◽  
History Of Disease ◽  
Accurate Treatment ◽  
Current Scenario ◽  
History Of

Diagnosis in Ayurveda is not always in terms of the name of the disease but in terms of the nature or phenomenon. This phenomenon is described in terms of Samprapti of the disease in each patient, comprising Dosha, Dushya and Adhishtana components. The prime factors in the pathogenesis of the disease are Dosha and Dushya. Shat kriyakala refers to the stage of development of a pathological process in which a physician can intervene by the most accurate treatment modality and medicine, thereby halting the progression of the disease process. By intricate understanding of the process of Shat kriyakala, the disease process could be arrested, and further complications can be avoided. In the current scenario, the concept of prevention has become broad-based. The natural history of disease is one of the significant elements of epidemiology. The course of a disease takes in individual people from its pathological onset until its eventual resolution. Natural history of disease is possible to correlate pre-pathogenesis with Sanchaya, Prakopa, Prasara and pathogenesis with Sthanasamsraya, Vyakti and Bhedavastha of Shat kriyakala. Recent studies have shown that it is possible to identify certain pre-clinical stages for many diseases like Parkinson’s disease, which can help in the early successful treatment. Shat kriyakala helps to arrest the disease process at the very early stage itself. Along with current technology, the need for research for validating the Shat kriyakala will benefit humankind in the long run.

scholarly journals Puelchesia gracilis, a new genus and species of Pachydemini endemic to the Monte biogeographic province in Argentina (Coleoptera: Scarabaeidae: Melolonthinae)

Zootaxa ◽  
2006 ◽  
Vol 1349 (1) ◽  
pp. 53 ◽  
Author(s):  
FEDERICO C. OCAMPO ◽  
ANDREW B.T. SMITH
Keyword(s):  
Natural History ◽  
New Genus ◽  
Scarab Beetle ◽  
New Genus And Species ◽  
Biogeographic Province ◽  
Central Argentina ◽  
West Central ◽  
Current Classification ◽  
History Of

A new scarab beetle genus and species, Puelchesia gracilis, is described based on specimens collected in the Monte biogeographic province of west central Argentina. This genus is placed in the tribe Pachydemini based on an evaluation of the characters within the context of the current classification of the subfamily Melolonthinae. The distribution and natural history of the taxon is also discussed.

scholarly journals Su1463 – Natural History of Disease Progression and Interventions After Aborted Pancreatoduodenectomy for Pancreatic Adenocarcinoma

2019 ◽  
Vol 156 (6) ◽  
pp. S-1445
Author(s):  
Timothy J. Vreeland ◽  
Timothy E. Newhook ◽  
Laura R. Prakash ◽  
Whitney L. Dewhurst ◽  
Morgan L. Bruno ◽  
...  
Keyword(s):  
Natural History ◽  
Disease Progression ◽  
Pancreatic Adenocarcinoma ◽  
History Of Disease ◽  
History Of
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