scholarly journals Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

2021 ◽  
Vol 11 ◽  
Author(s):  
Pieter Demetter ◽  
Raphaël Maréchal ◽  
Francesco Puleo ◽  
Myriam Delhaye ◽  
Sébastien Debroux ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Who Classification ◽  
Current Knowledge ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Rare Tumor ◽  
Carcinoma Of The Pancreas ◽  
Ductal Pancreatic Adenocarcinoma ◽  
Histological Appearance ◽  
Worse Prognosis

Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC.

scholarly journals Gallbladder carcinoma: An attempt of WHO histological classification on fine needle aspiration material

CytoJournal ◽  
2013 ◽  
Vol 10 ◽  
pp. 12 ◽  
Author(s):  
Rajni Yadav ◽  
Deepali Jain ◽  
Sandeep R. Mathur ◽  
Atul Sharma ◽  
Venkateswaran K. Iyer
Keyword(s):  
Fine Needle Aspiration ◽  
Who Classification ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Undifferentiated Carcinoma ◽  
World Health ◽  
Fine Needle ◽  
Signet Ring ◽  
Needle Aspiration Cytology ◽  
Health Organization

Background: Carcinoma of the gallbladder (CaGB) is common in India and its prognosis depends primarily on the extent of the disease and histological type. We aim to study the role of guided fine needle aspiration cytology (FNAC) for diagnosis of CaGB and to evaluate the feasibility of applying world health organization (WHO) classification on fine needle aspiration (FNA) material to predict the outcome of the tumor. Materials and Methods: Retrospective cytomorphologic analysis was performed in all cases of CaGB diagnosed by ultrasound (US) guided FNAC over a period of 2 years. A specific subtype was assigned according to WHO classification based on characteristic cytologic features. These included papillary or acinar arrangement, intra and extracellular mucin, keratin, rosettes and columnar, signet ring, atypical squamous, small, clear, spindle and giant cells. Correlation with histopathology was performed when available. Results: A total of 541 aspirations with clinical or radiological suspicion of primary CaGB were studied. Of these, 54 aspirates were unsatisfactory. Fifty cases were negative for malignancy. Remaining 437 aspirates were positive for carcinoma. Histopathologic diagnosis was available in 32 cases. Adenocarcinoma was the most frequent diagnosis in 86.7% of cases. Mucinous, signet ring, adenosquamous, squamous, small cell, mixed adenoneuroendocrine and undifferentiated carcinoma including spindle and giant cell subtypes were diagnosed identifying specific features on FNAC. Correlation with histopathology was present in all, but one case giving rise to sensitivity of 96.8%. No post-FNA complications were recorded. Conclusions: US guided FNAC is a safe and effective method to diagnose CaGB. Although, rare, clinically and prognostically significant variants described in WHO classification can be detected on cytology.

scholarly journals Undifferentiated carcinoma of pancreas with osteoclastic giant cells along with PanIN in a diabetic female- a case report

2020 ◽  
Vol 10 (1) ◽  
pp. 1687-1690
Author(s):  
Lakshmi Priya Unnikrishnan ◽  
Noushad Babu PK ◽  
Asiq Sideeque
Keyword(s):  
Case Report ◽  
Intraepithelial Neoplasia ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Anaplastic Carcinoma ◽  
Rare Tumor ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Carcinoma Of Pancreas ◽  
Epithelial Origin ◽  
Better Than

Undifferentiated carcinoma of pancreas with osteoclastic giant cells is a rare tumor. The prognosis is slightly better than usual anaplastic carcinoma. It is said to have an epithelial origin. We present a case of 61-year-old female who presented with features of cholangitis and on evaluation found to have pancreatic mass. Pancreatic intraepithelial neoplasia was also present in our case, which is a feature less commonly noted in published literature.

scholarly journals Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elisabetta Cavalcanti ◽  
Nicolo’ Schena ◽  
Grazia Serino ◽  
Giulio Lantone ◽  
Raffaele Armentano
Keyword(s):  
Weight Loss ◽  
Abdominal Pain ◽  
Pancreatic Carcinoma ◽  
Gold Standard ◽  
Genetic Basis ◽  
Performance Status ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Case Presentation ◽  
Disease Free

Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (UCOGCs) is a rare and aggressive non endocrine pancreatic carcinoma characterized by the presence of osteoclastic giant cells mixed with mononuclear cell. Very few cases have been reported in the literature and the histogenesis is controversial as, at the time of diagnosis, the tumor is often of advanced size and stage and it is difficult to pathologically observe its relationship with the pancreatic duct. Case presentation We present a case of 65-year-old male patient presenting with abdominal pain, nausea, and weight loss, which was treated with surgical resection. Histological examination revealed an undifferentiated pancreatic carcinoma with osteoclast-like giant cells. The patient underwent to a routine pylorus preserving pancreatoduodenectomy. Actually, the patient was in good performance status and disease-free five months. Conclusions Based on the present case and limited previous data, further researches preferably with large cohorts are necessary to clarify the pathogenesis of the neoplasm. However, as show in this case, histopathological and immunohistochemically studies are the gold standard for the diagnosis of UCPOGC. Investigation of the genomic alterations in UPOGCs could help to explain the histologic diversity of variant tumor and could provide a genetic basis for prognosis and treatment.

scholarly journals Morphologic Heterogeneity in Carcinosarcoma of the Gallbladder: Report of a Rare Cases

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Vani Krishnamurthy ◽  
Sheela Devi C. Shivalingiah ◽  
Sunila Ravishankar ◽  
Gubbanna V. Manjunath
Keyword(s):  
Giant Cell ◽  
Rare Case ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Rare Tumor ◽  
Cell Type ◽  
Epithelial Component ◽  
Giant Cell Type

Carcinosarcoma is a rare tumor composed of variable proportions of carcinomatous and sarcomatous elements and comprises less than one percent of all gallbladder malignancies. In most reported cases of carcinosarcoma of gallbladder, the epithelial component is adenocarcinoma. The mesenchymal component varies from homogenous sarcoma to more heterotopic elements like malignant bone, cartilage, and other mesenchymal tissues. We report a rare case of carcinosarcoma of the gallbladder in an 83-year-old male, with the carcinomatous component represented by undifferentiated carcinoma (spindle and giant cell type with osteoclastic giant cells) and the mesenchymal component seen as foci of chondrosarcoma.

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