Does PAX7 and NKX2.2 immunoreactivity in Ewing sarcoma have prognostic significance?

2022 ◽  
Author(s):  
Isidro Machado ◽  
Gregory W. Charville ◽  
Akihiko Yoshida ◽  
Samuel Navarro ◽  
Alberto Righi ◽  
...  
2014 ◽  
Vol 25 (10) ◽  
pp. 2080-2086 ◽  
Author(s):  
M.T. Marino ◽  
A. Grilli ◽  
C. Baricordi ◽  
M.C. Manara ◽  
S. Ventura ◽  
...  

Cancer ◽  
2007 ◽  
Vol 110 (6) ◽  
pp. 1351-1360 ◽  
Author(s):  
Kanya Honoki ◽  
Elizabeth Stojanovski ◽  
Mark McEvoy ◽  
Hiromasa Fujii ◽  
Toshifumi Tsujiuchi ◽  
...  

Author(s):  
Afaf Mohammad Mahmoud ◽  
Wael Zekri ◽  
Eman Naguib Khorshed ◽  
Lobna Mohamed Shalaby

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 413
Author(s):  
Maura Calvani ◽  
Marina Vignoli ◽  
Giovanni Beltrami ◽  
Amada Pasha ◽  
Perla Scalini ◽  
...  

Ewing sarcoma (EWS) is a paediatric aggressive malignant tumour of bones and soft tissues. Multidisciplinary chemotherapies, surgical resection, and radiation represent the only strategies counteracting the disease, however spreading and relapse of disease still remain a clinical issue. Circulating tumour cells (CTCs) are an important feature of EWS but the prognostic significance has not been, yet, clarified. CTCs have been found both in patients with localized disease and in those who recur or metastasize. The identification of markers that can detect recurrences and metastasis remains an important challenge for research. Unfortunately, even most of patients with localized cancer relapsed and the reason has not yet been fully understood. In this clinical study on EWS patients, we evaluated the expression of CD99 antigen and beta-3 adrenergic receptor (β3-AR) on CTCs and bioptic derived cells by flow cytometry. The preliminary data revealed a higher β3-AR expression on cells derived from metastatic or relapsed patients, suggesting a role for the β3-AR as a possible predictive maker of disease recurrence in both patients with metastatic and localized disease.


Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.


2007 ◽  
Vol 177 (4S) ◽  
pp. 127-128
Author(s):  
Michael Muntener ◽  
Jonathan I. Epstein ◽  
David J. Hernandez ◽  
Mark L. Gonzalgo ◽  
Leslie A. Mangold ◽  
...  

2005 ◽  
Vol 173 (4S) ◽  
pp. 218-218 ◽  
Author(s):  
Amir H. Arsanjani ◽  
Madhu Alagiri

2005 ◽  
Vol 2 (2) ◽  
pp. 107-109
Author(s):  
A. Mishra ◽  
M.F. Huda ◽  
V.P. Singh ◽  
S. Mohanty ◽  
A. Sodhi

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