Prognostic significance of survivin expression in pediatric ewing sarcoma

2021 ◽  
pp. 1-12
Author(s):  
Afaf Mohammad Mahmoud ◽  
Wael Zekri ◽  
Eman Naguib Khorshed ◽  
Lobna Mohamed Shalaby
Keyword(s):  
Ewing Sarcoma ◽  
Prognostic Significance ◽  
Survivin Expression

scholarly journals Prognostic Significance of Survivin Expression in Osteosarcoma Patients: A Meta-Analysis

2015 ◽  
Vol 21 ◽  
pp. 2877-2885 ◽  
Author(s):  
Yugang Liu ◽  
Zhaowei Teng ◽  
Ying Wang ◽  
Pengfei Gao ◽  
Junli Chen
Keyword(s):  
Meta Analysis ◽  
Prognostic Significance ◽  
Survivin Expression

scholarly journals Prognostic significance of miR-34a in Ewing sarcoma is associated with cyclin D1 and ki-67 expression

2014 ◽  
Vol 25 (10) ◽  
pp. 2080-2086 ◽  
Author(s):  
M.T. Marino ◽  
A. Grilli ◽  
C. Baricordi ◽  
M.C. Manara ◽  
S. Ventura ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Ewing Sarcoma ◽  
Prognostic Significance ◽  
Ki 67

Survivin Expression Predicts Poorer Prognosis in Anaplastic Large-Cell Lymphoma

2004 ◽  
Vol 22 (9) ◽  
pp. 1682-1688 ◽  
Author(s):  
Ellen J. Schlette ◽  
L. Jeffrey Medeiros ◽  
Andre Goy ◽  
Raymond Lai ◽  
George Z. Rassidakis
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Prognostic Significance ◽  
Survivin Expression ◽  
Large Cell ◽  
Rank Test ◽  
Anaplastic Lymphoma ◽  
Log Rank Test ◽  
Large Cell Lymphoma ◽  
Alk Positive

Purpose Survivin, a member of the inhibitor of apoptosis (IAP) family, is not detected in normal adult tissues but is overexpressed in various cancers, including some types of lymphoma. The frequency and prognostic significance of survivin expression in anaplastic large-cell lymphoma (ALCL) is unknown. Materials and Methods We assessed for survivin expression in 62 ALCL tumors (30 anaplastic lymphoma kinase [ALK]-positive and 32 ALK-negative) obtained before doxorubicin-based chemotherapy. Given that survivin is a target of the STAT3 signaling pathway and STAT3 is activated in ALCL, survivin expression was also correlated with STAT3 activation. Results Survivin was expressed in 34 tumors (55%) and did not correlate with ALK. A significant association between survivin expression and STAT3 activation was observed (P = .007, Fisher's exact test). For the ALK-positive group, the 5-year failure-free survival (FFS) was 34% for patients with survivin-positive ALCL compared with 100% for patients with survivin-negative ALCL (P = .009, log-rank test). For the ALK-negative group, the 5-year FFS was 46% for patients with survivin-positive tumors compared with 89% for patients with survivin-negative tumors (P = .03, log-rank test). Overall survival was similarly worse for patients with survivin-positive tumors in both the ALK-positive and ALK-negative groups. Furthermore, multivariate analysis confirmed the independent prognostic value of survivin expression, along with age older than 60 years and Ann Arbor stage III or IV. Conclusion Survivin is expressed in approximately half of ALCL tumors and independently predicts unfavorable clinical outcome. Modulation of survivin expression or function may provide a novel target for experimental therapy in patients with ALCL.

scholarly journals The Prognostic Significance of Survivin Expression in Breast Cancer

2009 ◽  
Vol 12 (4) ◽  
pp. 285 ◽  
Author(s):  
Jae-Won Oh ◽  
Woo-Ick Yang ◽  
Mi Jeong Lee ◽  
Seho Park ◽  
Byeong-Woo Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Significance ◽  
Survivin Expression

scholarly journals Prognostic Significance of High Survivin Expression in Patients with Gastrointestinal Cancer: A Meta-Analysis

2017 ◽  
Author(s):  
Pingping Xu ◽  
Jiajia Lin ◽  
Qi Lin ◽  
Dexiang Zhu ◽  
Wentao Tang ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Survivin Expression ◽  
Disease Free Survival ◽  
Cochrane Library ◽  
Prognostic Impact ◽  
Gi Cancer ◽  
Literature Searches ◽  
The Cochrane Library

Previous studies on the prognostic impact of survivin expression in gastrointestinal (GI) cancer have yielded inconsistent results. This study was initiated to assess the relationship between survivin expression and overall survival (OS) or disease free survival (DFS) in GI cancer patients. We applied system literature searches on EMBASE, PubMed, Web of science, and the Cochrane library to conduct this up-to-date meta-analysis. Thirty studies with totally 3622 GI cancer patients were collected. The prevalence of high survivin expression in GI cancer was 0.57 (95% CI: 0.51-0.63). High survivin expression was significantly associated with shorter OS (HR 1.57, 95% CI: 1.42-1.74) and DFS (HR 1.38, 95% CI: 1.21-1.58). Subgroup analysis also showed significant association between high survivin expression and poorer OS or DFS in gastric cancer or colorectal cancer. In summary, our study indicated that high survivin expression was related to poor prognosis in GI cancer. Well-designed studies with large sample and more convincing data are needed to confirm our conclusion.

scholarly journals Clinicopathological and Prognostic Significance of Inhibitor of Apoptosis Protein (IAP) Family Members in Lung Cancer: A Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4098
Author(s):  
Stephen Fung ◽  
Wolfram Trudo Knoefel ◽  
Andreas Krieg
Keyword(s):  
Lung Cancer ◽  
Meta Analysis ◽  
Strong Association ◽  
Prognostic Significance ◽  
Survivin Expression ◽  
Disease Recurrence ◽  
Small Cell ◽  
Inhibitor Of Apoptosis ◽  
Lung Cancer Patients ◽  
Apoptosis Protein

Lung cancer is the most common cause of cancer-related death worldwide. Approximately 85% is non-small-cell and 15% is small-cell lung cancer. The inhibitor of apoptosis proteins (IAPs) represent a heterogeneous family of anti-apoptotic proteins, some members of which have been reported to correlate with clinical outcome in lung cancer. We screened PubMed, Web of Science, and Scopus for studies that investigated the prognostic value and clinicopathological features of IAPs in lung cancer. Forty-five eligible studies with 4428 patients assessed the expression of the IAPs survivin, XIAP, livin, and BRUCE. The pooled hazard ratio (HR) of 33 studies that analyzed overall survival (OS) revealed a positive correlation between survivin expression and poor prognosis. Seven studies displayed a strong association between survivin and disease recurrence. Two studies that assessed the expression of XIAP and livin, respectively, proved a significant relationship of these IAPs with poor OS. Meta-analyses of clinicopathological variables revealed a significant association between survivin and T stage, UICC stage, the presence of lymph node metastasis, and grade of differentiation. In conclusion, high expression of distinct IAPs significantly correlates with prognosis in lung cancer. Therefore, lung cancer patients might benefit from a targeted therapy against specific IAPs.

scholarly journals Expression Profile of Survivin and p16 in Laryngeal Squamous Cell Carcinoma: Contribution of Tunisian Patients

2019 ◽  
Vol 100 (1) ◽  
pp. NP7-NP15 ◽  
Author(s):  
Mariem Ben Elhadj ◽  
Olfa E. L. Amine ◽  
Nehla Mokni Baizig ◽  
Wided Ben Ayoub ◽  
Aida Goucha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Significance ◽  
Survivin Expression ◽  
Clinicopathological Parameters ◽  
Therapeutic Protocol ◽  
Tunisian Patients ◽  
P16 Expression

The objective of this study was to evaluate the expression of survivin and p16 in laryngeal squamous cell carcinoma (LSCC) in order to analyze their pathogenesis and prognostic significance in Tunisian patients. A total of 70 patients with LSCC collected at the Salah Azaiez Cancer Institute of Tunis were retrospectively evaluated. Expression of survivin and p16 was examined using immunohistochemistry, and the correlations with clinicopathological parameters, overall survival (OS), and disease-free survival (DFS) were statistically evaluated. The positive expression of survivin and p16 were found in 58.6% and 51.43% of LSCC cases, respectively. The p16 expression was not associated with either clinical parameters or patient survival, whereas there was a strong correlation of survivin expression and lymph node metastases ( P = .002), alcohol consumption ( P = .024), and therapeutic protocol (with or without chemotherapy; P = .001). Kaplan-Meier survival curves showed that patients with LSCC having positive survivin expression have shorter OS ( P = .026) and shorter DFS ( P = .01) than those with negative expression. Positive survivin expression was also correlated with high recurrence rate ( P = .014). Therefore, survivin is a poor prognostic marker for LSCC but the therapeutic protocol remains, in multivariate study, the most decisive for the OS and DFS of our patients with P < .01. Our data indicated that, in Tunisian laryngeal squamous cell carcinoma, survivin expression is associated with unfavorable outcomes and represents a predictor marker of recurrence and chemoresistance. However, p16 expression has no prognosis value.

Sign in / Sign up

Export Citation Format

Share Document