Specific expression of the mRNA for 25 kDA heat-shock protein in the spermatocytes of mouse seminiferous tubules

1999 ◽  
Vol 199 (5) ◽  
pp. 419-425 ◽  
Author(s):  
T. Wakayama ◽  
S. Iseki
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Seminiferous Tubules ◽  
Specific Expression

Elevated Retina-Specific Expression of the Small Heat Shock Protein, αA-crystallin, Is Associated with Photoreceptor Protection in Experimental Uveitis

2008 ◽  
Vol 49 (3) ◽  
pp. 1161 ◽  
Author(s):  
Narsing A. Rao ◽  
Sindhu Saraswathy ◽  
Guey Shuang Wu ◽  
George S. Katselis ◽  
Eric F. Wawrousek ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Small Heat Shock Protein ◽  
Specific Expression

scholarly journals Selective renal overexpression of human heat shock protein 27 reduces renal ischemia-reperfusion injury in mice

2010 ◽  
Vol 299 (2) ◽  
pp. F347-F358 ◽  
Author(s):  
Minjae Kim ◽  
Sang Won Park ◽  
Mihwa Kim ◽  
Sean W. C. Chen ◽  
William T. Gerthoffer ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Fluorescent Protein ◽  
Ischemia Reperfusion Injury ◽  
Therapeutic Option ◽  
Ischemia Reperfusion ◽  
Heat Shock Protein 27 ◽  
Renal Ischemia ◽  
Specific Expression ◽  
Mrna Induction

We have previously shown that exogenous and endogenous A1 adenosine receptor (A1AR) activation protected against renal ischemia-reperfusion (IR) injury in mice by induction and phosphorylation of heat shock protein 27 (HSP27). With global overexpression of HSP27 in mice, however, there was a paradoxical increase in systemic inflammation with increased renal injury after an ischemic insult due to increased NK1.1 cytotoxicity. In this study, we hypothesized that selective renal expression of HSP27 in mice would improve renal function and reduce injury after IR. Mice were subjected to renal IR injury 2 days after intrarenal injection of saline or a lentiviral construct encoding enhanced green fluorescent protein (EGFP) or human HSP27 coexpressing EGFP (EGFP-huHSP27). Mice with kidney-specific reconstitution of huHSP27 had significantly lower plasma creatinine, renal necrosis, apoptosis, and inflammation as demonstrated by decreased proinflammatory cytokine mRNA induction and neutrophil infiltration. In addition, there was better preservation of the proximal tubule epithelial filamentous (F)-actin cytoskeleton in the huHSP27-reconstituted groups than in the control groups. Furthermore, huHSP27 overexpression led to increased colocalization with F-actin in renal proximal tubules. Taken together, these findings have important clinical implications, as they imply that kidney-specific expression of HSP27 through lentiviral delivery is a viable therapeutic option in attenuating the effects of renal IR.

scholarly journals Regional Induction of c-Fos and Heat Shock Protein-72 mRNA following Fluid-Percussion Brain Injury in the Rat

1995 ◽  
Vol 15 (3) ◽  
pp. 467-473 ◽  
Author(s):  
Ramesh Raghupathi ◽  
Frank A. Welsh ◽  
Daniel H. Lowenstein ◽  
Thomas A. Gennarelli ◽  
Tracy K. McIntosh
Keyword(s):  
Brain Injury ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cellular Response ◽  
Granule Cells ◽  
Subcortical White Matter ◽  
Specific Expression ◽  
Fluid Percussion ◽  
Lateral Fluid Percussion ◽  
The Impact

To evaluate the cellular response to traumatic brain injury, the expression of mRNA for c- fos and the 72-kDa heat shock protein (hsp72) was determined using in situ hybridization following lateral fluid-percussion injury (2.2–2.4 atm) in rat brain. At 2 h after injury, induction of c- fos mRNA was observed throughout the cortex ipsilateral to the site of injury, while increased expression of hsp72 mRNA was restricted to regions of the cortex surrounding the contusion area. An increase in c- fos mRNA, but not hsp72 mRNA, was observed bilaterally in the CA3 subfield of the hippocampus and the granule cells of the dentate gyrus and in the thalamus ipsilateral to the impact site. By 6 h, increased expression of c- fos mRNA was observed only in the corpus callosum on the impact side; hsp72 mRNA persisted in the deep cortical layers and upper layers of the subcortical white matter below the site of maximal injury. By 24 h, both c- fos and hsp72 mRNA had returned to control levels in all regions of the brain. These results demonstrate that lateral fluid– percussion brain injury triggers regionally and temporally specific expression of c- fos and hsp72 mRNA, which may be suggestive of differential neurochemical alterations in neurons and glia following experimental brain injury.

Stage-Specific Expression of Heat Shock Protein 90 in Murine Malaria Parasite Plasmodium yoelii

1999 ◽  
Vol 93 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Manxin Zhang ◽  
Hajime Hisaeda ◽  
Takafumi Tsuboi ◽  
Motomi Torii ◽  
Tohru Sakai ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Malaria Parasite ◽  
Heat Shock Protein 90 ◽  
Plasmodium Yoelii ◽  
Specific Expression ◽  
Parasite Plasmodium

The independent stage-specific expression of the 18-kDa heat shock protein genes during microsporogenesis inZea mays L

1993 ◽  
Vol 14 (1) ◽  
pp. 15-26 ◽  
Author(s):  
Burr G. Atkinson ◽  
Manish Raizada ◽  
Robert A. Bouchard ◽  
J. Roger H. Frappier ◽  
David B. Walden
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Specific Expression ◽  
Heat Shock Protein Genes

scholarly journals Erythroid lineage-specific expression and inducibility of the major heat shock protein HSP70 during avian embryogenesis.

1987 ◽  
Vol 1 (9) ◽  
pp. 946-953 ◽  
Author(s):  
S S Banerji ◽  
K Laing ◽  
R I Morimoto
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Specific Expression ◽  
Heat Shock Protein Hsp70
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