The time of umbilical cord separation in healthy full-term newborns: a controlled clinical trial of different cord care practices

2003 ◽  
Vol 162 (5) ◽  
pp. 350-351 ◽  
Author(s):  
Andrea Guala ◽  
Guido Pastore ◽  
Vasco Garipoli ◽  
Mario Agosti ◽  
Marco Vitali ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Umbilical Cord ◽  
Full Term ◽  
Controlled Clinical Trial ◽  
Cord Care ◽  
Term Newborns ◽  
Care Practices

scholarly journals Umbilical cord medication in healthy full-term newborns: a before-after uncontrolled quality improvement study

2020 ◽  
Author(s):  
Alessandra Coscia ◽  
Giovanni Boscarino ◽  
Maria Di Chiara ◽  
Francesca Faccioli ◽  
Roberto Pedicino ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Stress Level ◽  
Full Term ◽  
Rank Test ◽  
Cord Care ◽  
Arnica Montana ◽  
Phone Calls ◽  
Antiseptic Treatment ◽  
Term Newborns

AbstractUmbilical cord care can be a stressful practice for parents. Complications of cord care can increase neonatal morbidity and mortality. The extracts of Arnica montana (AM) have been reported to possess antibacterial, anti-inflammatory, antifungal, and immunomodulatory activities. We aim to demonstrate the efficacy of AM on cord detachment and parents’ stress level induced by cord medication in healthy full-term newborns. We enrolled full-term infants with a birth weight ≥ 2500 g in healthy conditions. Cord stumps of infants in the PRE-group were cleaned and dried, while cord stumps of infants in the POST-group were cleaned, dried, and medicated with a natural topic dermo-protective powder containing AM. After discharge, we interviewed parents on the stump status during follow-up visits in a pediatric office at 7 and 14 days of life, or by phone calls after follow-up visits. Long-rank test showed that time of cord separation of newborns in the PRE-group was significantly higher compared to that in the POST-group (p < 0.001). Parents of newborns in the PRE-group were significantly more stressed during cord medication compared to parents in the POST-group (2.0 (1.2 to 2.1) vs 1.0 (0.8 to 1.3), p = 0.011). Multivariate analysis showed a significantly linear relation with group assignment for cord separation (p < 0.001) and parents’ stress during the medication (p = 0.033).Conclusion: The use of a natural topic dermo-protective powder containing AM reduces the time of cord separation, improves parents’ stress level, and reduces the risk of complications. What is Known:• Cord stump care can be a stressful practice for parents.• Antiseptic treatment recommended for cord care could be associated with side effects such as burning and sensitization. What is New:• The medication of cord stump with a natural topic dermo-protective powder containing Arnica montana reduces time of cord detachment and of complication such as redness’, bleeding, or secretions.• The use of Arnica montana for cord medication may have a positive impact on the family, reducing parents’ stress, and the use of other medications.

scholarly journals Randomized clinical trial of the effect of the onset time of skin-to-skin contact at birth, immediate compared to early, on the duration of breastfeeding in full term newborns

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Sergio I Agudelo ◽  
Oscar A Gamboa ◽  
Eduardo Acuña ◽  
Lina Aguirre ◽  
Sarah Bastidas ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Exclusive Breastfeeding ◽  
Negative Impact ◽  
Onset Time ◽  
Full Term ◽  
Breastfeeding Duration ◽  
Bivariate Analysis ◽  
Skin Contact ◽  
Term Newborns ◽  
Skin To Skin

Abstract Background Skin-to-skin contact (SSC) compared to separation at birth has a positive effect on breastfeeding. However, separation at birth is common with negative impact on breastfeeding. The aim was to determine the effect of immediate SSC compared to early SSC on the duration of exclusive breastfeeding. Methods A randomized multicentre parallel clinical trial was conducted in two hospitals in Cundinamarca (Colombia) between November 2018 and January 2020. Low-risk full term newborns at birth were included. Neonates were assigned to immediate (in the first minute after birth) or early onset (start exactly at 60 min of life) skin to skin contact. Monthly follow-up was performed until 6 months of age. The primary outcome was the percentage of exclusively breastfed infants at 6 months (time in months with human milk as the only source of food). Secondary outcomes were the percentage of infants with exclusive breastfeeding at 3 months, duration in months of exclusive breastfeeding, neonate’s breastfeeding ability, percentage of weight change between birth and the first week of life and hospitalization in the neonatal unit in the first week. A bivariate analysis was performed to determine the variables associated with exclusive breastfeeding at 6 months. A survival analysis was performed to evaluate the effect of the onset of SSC on exclusive breastfeeding duration. Results A total of 297 newborns were included: 49.8% (n = 148) in the immediate SSC group, and 50.2% (n = 149) in the early SSC group. The mean duration of exclusive breastfeeding in both groups was 5 months. There were no differences between the groups in the percentage of exclusive breastfeeding at 6 months (relative risk [RR] 1.06, 95% CI 0.72, 1.58) or in the duration of exclusive breastfeeding (hazard ratio [HR] 0.98, 95% CI 0.74, 1.28). Conclusions The percentage of infants and the duration of exclusive breastfeeding in the first 6 months of age were the same between the two groups of SSC interventions. Given the current barriers to its implementation, the results of this study could positively impact the use of SSC at birth and standardize the intervention and improve breastfeeding indicators. Trial registration ClinicalTrials.gov NCT02687685.

­Evaluation of Immediate and Short-Term Efficacy of DualStim Therapy with and without Intracavernosal Umbilical Cord-Derived Wharton’s Jelly in Patients with Erectile Dysfunction: Study Protocol for a Pilot Randomised Controlled Trial

2020 ◽  
Author(s):  
Ashim Gupta ◽  
Hugo C. Rodriguez ◽  
Kristin Delfino ◽  
Howard J. Levy ◽  
Saadiq F. El-Amin III ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Erectile Dysfunction ◽  
Umbilical Cord ◽  
Erectile Function ◽  
Wharton’S Jelly ◽  
Post Treatment ◽  
Controlled Clinical Trial ◽  
Short Term ◽  
Wharton's Jelly ◽  
Term Efficacy

Abstract Background Erectile Dysfunction (ED) affects a significant portion of the U.S. population and causes negative psychological burdens that affects men and their partner’s quality of life and satisfaction. Extracorporeal shock therapy (ESWT) utilizing focused ESWT (fESWT) and radial ESWT (rESWT) in Low-intensity shock wave therapy (LSIWT) has been used to treat ED with some success. Wharton’s Jelly (WJ) is a biologic substance with large amounts of stem cells, growth factors, cytokines and extracellular components. The use of simultaneous fESWT and rESWT (DualStim Therapy) combined with WJ have potential uses in ED that may have advantages over current treatments. Methods A randomized, single-blinded, controlled clinical trial will be conducted to evaluate the efficacy and safety of DualStim Therapy and ICIs of WJ in moderate to severe ED. A total of 60 patients with moderate to severe ED will be enrolled and treated with DualStim Therapy with intracavernosal injection (ICIs) of WJ or saline for a period of 7 weeks. The International Index of Erectile Function – Erectile Function (IIEF-EF) score will be used to gauge the treatment related changes in relation to the subject’s baseline. The scores will be recorded at baseline and compared to follow-ups 1,3 and 6 months post-treatment. Any Adverse events (AEs) or severe AEs will be recorded in the corresponding case report forms (CRFs). Sexual Encounter Profile (SEP), as well as the Global Assessment Questionnaire (GAQ) and the Erection Hardness Score (EHS) will be used to determine the sexual activity improvement from baseline leading to optimal penetration at follow-ups 1,3 and 6 months post-treatment.Discussion This clinical trial is a feasibility study to determine the immediate and short-term efficacy of DualStim Therapy, with and without ICIs of formulated umbilical cord-derived WJ to improve and/or restore erectile function in patients with moderate to severe ED. This study will also provide insight into the safety and efficacy of WJ. We anticipate clinically significant improvement in patients suffering from moderate and severe ED treated with DualStim therapy with WJ compared to their baseline and DualStim with saline.Trial registration Registered on ClinicalTrials.gov; the trial number is NCT04424394

Umbilical cord serum lipids between early and late clamping in full-term newborns. A systematic assignment treatment group

2014 ◽  
Vol 28 (2) ◽  
pp. 186-189 ◽  
Author(s):  
Jesús Florido ◽  
Catalina de Paco-Matallana ◽  
M. Soledad Quezada ◽  
M. Carmen Garrido-Sánchez ◽  
Carmen Padilla ◽  
...  
Keyword(s):  
Treatment Group ◽  
Umbilical Cord ◽  
Serum Lipids ◽  
Full Term ◽  
Cord Serum ◽  
Term Newborns

scholarly journals Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

2021 ◽  
Vol 6 (2) ◽  
pp. 133-141
Author(s):  
M. S. Panova ◽  
A. S. Panchenko ◽  
V. A. Mudrov
Keyword(s):  
Cord Blood ◽  
Brain Damage ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Full Term ◽  
Damage Diagnosis ◽  
Hypoxic Brain Damage ◽  
Hypoxic Brain ◽  
Tnf Α ◽  
Term Newborns

The problem of early diagnosis of the central nervous system damage in newborn before the onset of clinical symptoms remains relevant at the present time.The aim of the study was to optimize the hypoxic brain damage diagnosis in full-term newborns by analyzing the concentration of cytokines in the umbilical cord blood.Materials and methods. During the first stage of the study, a prospective analysis of concentrations of interleukins (IL-1β, IL-4, IL-6, IL-8, IL-10), TNF-α and neuron-specific enolase (NSE) in the umbilical cord blood serum of full-term newborns was performed. The second stage of the study included the retrospective analysis of clinical data and instrumental research methods. The main method for diagnosing in the development of hypoxic brain damage in newborns was neurosonography.Results. The development of hypoxic brain damage is evidenced by the concentration of IL-1β over 30.3 pg/ml, IL-4 – over 1.7 pg/ml, IL-6 – over 79.4 pg/ml, IL-8 – over 107.7 pg/ml, NSE – more than 10.3 ng/ml and TNF-α – more than 1.6 pg/ml in umbilical cord blood.Conclusion. The results of the study confirmed that the comprehensive assessment of the cytokines concentration in the umbilical cord blood improves the hypoxic brain damage diagnosis in newborns. Analysis of the level of these markers immediately after the birth will optimize the management tactics of newborns who have undergone hypoxic exposure in antenatal and intranatal period. 

scholarly journals Predictors of Omphalitis among Spontaneous Vertex Delivery Neonates in Nakuru County Hospital, Kenya

2020 ◽  
Vol 8 (07) ◽  
pp. 371-381
Author(s):  
Lucy Kinanu ◽  
James Mwaura ◽  
Anne Karani
Keyword(s):  
Developing Countries ◽  
Hand Hygiene ◽  
Randomized Trial ◽  
Umbilical Cord ◽  
Infection Prevention ◽  
County Hospital ◽  
Cord Care ◽  
Neonatal Infections ◽  
Neonatal Deaths ◽  
Care Practices

Background; Omphalitis (umbilical cord infection) among new-borns is common and a major cause of neonatal deaths in developing countries. Annually, about 4 million neonatal deaths occur around the world. Of these, >30% are caused by infections that mainly from umbilical cord. Cord care practices may directly contribute neonatal infections, largely contributing tothis was part data from a larger randomized trial among 540 participant’s neonatal deaths. Cord infections are more prevalent in developing countries because of the high rates of poverty and unhygienic practices. Objective: To determine the predictors of omphalitis among neonates in Nakuru County Hospital, Kenya. Methodology This was part data from a larger randomized trial among 540 participants. Findings: The prevalence of Omphalitis was 23.1. Babies whose mothers’ did not wash hands when eating had 2.14 times risk of developing cord infection compared to those babies whose mothers’ indicated otherwise [AOR=2.14; 95%CI=1.28 - 3.57; p=0.004]. Likewise, babies whose mothers’ never folded diapers backwards were twice likely over those who did to develop cord infection [AOR=1.88; 95%CI=1.03 - 3.44; p=0.039]. Babies whose mothers’ stayed in different rooms had 7.35 times risk of developing cord infection [AOR=7.35; 95%CI=3.40 - 15.91; p<0.001] over those roomed in. Conclusion and recommendation: Maternal and caretakers hand hygiene, folding back of diapers and rooming in are critical in cord infection prevention. Health education to mothers and care takers on the importance of hand hygiene, diaper application and importance of rooming in is recommended to minimise omphalitis and consequential morbidity.

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