Weight loss and body mass index in advanced gastric cancer patients treated with second-line ramucirumab: a real-life multicentre study

2019 ◽  
Vol 145 (9) ◽  
pp. 2365-2373 ◽  
Author(s):  
Alessandro Parisi ◽  
Alessio Cortellini ◽  
Michela Roberto ◽  
Olga Venditti ◽  
Daniele Santini ◽  
...  
2018 ◽  
Vol 27 (8) ◽  
pp. 955-962 ◽  
Author(s):  
Young Suk Park ◽  
Do Joong Park ◽  
Yoontaek Lee ◽  
Ki Bum Park ◽  
Sa-Hong Min ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Yong-jie Zhang ◽  
Qi Min ◽  
Ying Huang ◽  
Huai-dong Liu ◽  
Zi-yuan Zhu ◽  
...  

Objective. To explore whether acupuncture and moxibustion can prevent disease progression of advanced gastric cancer patients completing second-line chemotherapy and, if so, the related mechanism. Method. Progression-free survival (PFS) and overall survival (OS) were main outcome measures. The real-time quantitative PCR was used to detect the expression of genes including T-bet, IFN-γ, GATA3, and IL-4 in peripheral blood mononuclear cells (PBMCs). IL-4, IL-6, Ca199, CRP, and IFN-γ in plasma levels were checked. Results. 170 patients were randomly assigned in a 3 : 2 ratio to receive either acupuncture and moxibustion or sham acupuncture until progression. 135 patients were included in the primary analysis. Both PFS and OS in treatment group were proven to be better than control group. Acupuncture and moxibustion promoted typical Th1 cells drifting, as confirmed by increased T-bet/IFN-γ and decreased GATA3/IL-4 in mRNA levels from PBMCs, as well as upregulating IFN-γ and downregulating IL-4 in plasma levels. IL-6, Ca199, and CRP in plasma levels were also reduced by acupuncture and moxibustion. Conclusions. Acupuncture and moxibustion can prolong PFS and OS of advanced gastric cancer patients completing second-line chemotherapy by reversing Th1/Th2 shift and attenuating inflammatory responses.


2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e15553-e15553
Author(s):  
Valentina Fanotto ◽  
Caterina Fontanella ◽  
Mario Uccello ◽  
Giulia Pasquini ◽  
Silvia Bozzarelli ◽  
...  

2015 ◽  
Vol 51 ◽  
pp. S454-S455
Author(s):  
C. Fontanella ◽  
V. Fanotto ◽  
M. Uccello ◽  
E. Vasile ◽  
S. Bozzarelli ◽  
...  

2003 ◽  
Vol 10 (4) ◽  
pp. 363-368 ◽  
Author(s):  
Stephan Gretschel ◽  
Frank Christoph ◽  
Andreas Bembenek ◽  
Lope Estevez-Schwarz ◽  
Ulrike Schneider ◽  
...  

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