Serum factor(s) from lung adenocarcinoma patients regulates the molecular clock expression

Summary50 years old man suffering from primary lung adenocarcinoma presented with high levels of both beta subunit human chorionic gonadotropin (βHCG) and cancer antigen 15-3 (CA 15-3) in the absence of elevated carcinoembrionic antigen (CEA), alfa fetoprotein (AFP) and carbohydrate antigen 19-9 (CA 19-9). Although βHCG or CA 15-3 high levels were reported in adenocarcinoma of lung, this is the first report of a patient with high levels of both markers.

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Mouse Trophoblast Cells Are Constitutive Producers of Thromboplastin (Factor III) In Vitro

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657867 ◽

1985 ◽

Vol 54 (02) ◽

pp. 438-441 ◽

Cited By ~ 5

Author(s):

K Dalaker ◽

E Haug ◽

H Prydz

Keyword(s):

Complement System ◽

Serum Factor ◽

Trophoblast Cells ◽

Thromboplastin Factor

SummaryTrophoblasts from murine placenta synthesize thromboplastin in the absence of inducing agents and a functional complement system, nor is the rate or level of synthesis enhanced by inducers. A serum factor which is destroyed/removed by addition of oxalate and subsequent dialysis appears to enhance the ability of trophoblasts to synthesize thromboplastin.

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Prostacyclin Synthesis Is Stimulated by a Serum Factor Formed During Coagulation

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657316 ◽

1983 ◽

Vol 49 (01) ◽

pp. 058-060 ◽

Cited By ~ 12

Author(s):

J M Ritter ◽

M-A Ongari ◽

M A Orchard ◽

P J Lewis

Keyword(s):

Renal Failure ◽

Hydrolysis Product ◽

Healthy Controls ◽

Serum Factor ◽

Intrinsic Pathway ◽

Extrinsic Pathway ◽

Stimulatory Activity ◽

Plasma Factor ◽

Stimulating Factor ◽

Prostacyclin Synthesis

SummaryFresh aortic rings incubated in serum produce more 6-oxo-PGF1α, the stable hydrolysis product of prostacyclin, than in plasma or buffer. A method is described of recovering this stimulatory activity from a dialysate of serum, showing that the activity is due to a prostacyclin stimulating factor. This factor is formed during coagulation initiated by the intrinsic pathway but not by the extrinsic pathway or by thrombin. By contrast with a previously described plasma factor, the activity of the prostacy-clinstimulating factor in serum is not greater in serum from patients with renal failure than from healthy controls. The stimulating factor is antagonised by heparin, but differs in other ways from previously described platelet derived stimulating factor(s).

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