In vivo treatment with nitazoxanide induces anaerobic metabolism in experimental intraperitoneal cysticercosis

2017 ◽  
Vol 116 (11) ◽  
pp. 3037-3041 ◽  
Author(s):  
Joelma M. Nasareth ◽  
Carolina M. Fraga ◽  
Nayana F. Lima ◽  
Guaraciara A. Picanço ◽  
Tatiane L. Costa ◽  
...  
1981 ◽  
Vol 11 (4) ◽  
Author(s):  
M.C. Fioretti ◽  
B. Nardelli ◽  
R. Bianchi ◽  
C. Nisi ◽  
G. Sava

2010 ◽  
Vol 70 (2) ◽  
pp. 425-434 ◽  
Author(s):  
WR Barrionuevo ◽  
MN Fernandes ◽  
O Rocha

In order to verify the influence of chronic and acute ambient oxygen levels from egg to adult stage of the zebrafish, in vivo oxygen consumption (MO2), critical tensions of oxygen (Pcrit), heart rate (fH) and total body lactate concentration (Lc) were determined for Danio rerio (Hamilton, 1822) raised at 28 °C under normoxic (7.5 mgO2.L-1 or 80 mm.Hg-1) and hypoxic conditions (4.3 mgO2.L-1) and exposed to acute hypoxia during different developmental stages. Our findings confirmed that very early stages do not respond effectively to ambient acute hypoxia. However, after the stage corresponding to the age of 30 days, D. rerio was able to respond to acute hypoxia through effective physiological mechanisms involving aerobic and anaerobic metabolism. Such responses were more efficient for the fishes reared under hypoxia which showed that D. rerio survival capability increased during acclimation to mild hypoxia. Measurements of body mass and length showed that moderate hypoxia did not affect growth significantly until the fish reached the stage of 60 days. Moreover, a growth delay was verified for the hypoxic-reared animals. Also, the D. rerio eggs-to-larvae survival varied from 87.7 to 62.4% in animals reared under normoxia and mild hypoxia, respectively. However, the surviving animals raised under moderated hypoxia showed a better aptitude to regulate aerobic and anaerobic capacities when exposed to acute hypoxia.


Immunobiology ◽  
2016 ◽  
Vol 221 (2) ◽  
pp. 368-376 ◽  
Author(s):  
Joyle Moreira Carvalho da Silva ◽  
Augusto das Neves Azevedo ◽  
Rebeca Pinheiro dos Santos Barbosa ◽  
Thais Andressa Gonçalves Vianna ◽  
Juliana Fittipaldi ◽  
...  

2010 ◽  
Vol 53 (3) ◽  
pp. 575-582 ◽  
Author(s):  
Jacques Natan Grinapel Frydman ◽  
Adenilson de Souza da Fonseca ◽  
Vanessa Câmara da Rocha ◽  
Monica Oliveira Benarroz ◽  
Gabrielle de Souza Rocha ◽  
...  

This work evaluated the effect of in vitro and in vivo treatment with ASA on the morphology of the red blood cells. Blood samples or Wistar rats were treated with ASA for one hour. Blood samples or animals treated with saline were used as control group. Blood smears were prepared, fixed, stained and the qualitative and quantitative morphology of red blood cells were evaluated under optical microscopy. Data showed that the in vitro treatment for one hour with ASA at higher dose used significantly (p<0.05) modified the perimeter/area ratio of the red blood cells. No morphological alterations were obtained with the in vivo treatment. ASA use at highest doses could interfere on shape of red blood cells.


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