Less pain after transvaginal cholecystectomy: single-center pooled analysis

Background: Recent studies have shown that tPA can be safely administered past the standard 4.5hr window with good outcomes when selected with multi-model imaging, which is often lacking outside of comprehensive stroke centers. Aim: We aim to analyze the safety and outcomes of wake up/unknown onset (WUS/UNK) patients treated based on non-contrast head CT (NCCT) at our institution and in the literature. Methods: Suspected stroke patients from 01/2015-12/2018 receiving tPA within 4.5 hours (standard window-SW) and with WUS/UNK based on NCCT and clinical-imaging mismatch were identified. We compared baseline characteristics, tPA metrics, and outcome data, with primary outcome as symptomatic intracerebral hemorrhage (sICH). A meta-analysis was performed evaluating NCCT-based treatment of WUS/UNK patients. Results: Of 1827 patients treated at our hub or through telestroke, 93 underwent WUS/UNK-based treatment. There was no statistical difference in sICH between WUS/UNK and SW: 1% vs 4% (OR 0.3; 95% confidence interval 0.0-1.9). 90-day modified Rankin scale outcomes were similar between SW and WUS/UNK treated patients. Seven studies encompassing 485 WUS/UNK patients were included in a pooled analysis with a 2.1% incidence of sICH. In our meta-analysis, three studies compared NCCT-based treated WUS/UNK patients with SW patients with no difference in rate of hemorrhage: 2.1% vs 3.4% (OR 1.01; 95% confidence interval 0.45-2.28). Interpretation: Our single-center analysis and meta-analysis suggest that tPA can be safely administered based on NCCT with comparable rates of sICH for select WUS/UNK stroke patients.

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Postoperative pain after transvaginal cholecystectomy: single-center, double-blind, randomized controlled trial

Surgical Endoscopy ◽

10.1007/s00464-013-3409-2 ◽

2014 ◽

Vol 28 (6) ◽

pp. 1886-1894 ◽

Cited By ~ 21

Author(s):

Dietmar H. Borchert ◽

Matthias Federlein ◽

Frauke Fritze-Büttner ◽

Jens Burghardt ◽

Britta Liersch-Löhn ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Postoperative Pain ◽

Controlled Trial ◽

Single Center ◽

Transvaginal Cholecystectomy ◽

Double Blind ◽

Randomized Controlled

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Abstract TP26: Benefit of Endovascular Therapy Across Clinical Trial Design and Technique: A Single Center Pooled Analysis

Stroke ◽

10.1161/str.50.suppl_1.tp26 ◽

2019 ◽

Vol 50 (Suppl_1) ◽

Author(s):

Ashutosh P Jadhav ◽

Shashvat Desai ◽

Ruchira Jha ◽

Tudor Jovin

Keyword(s):

Clinical Trial ◽

Endovascular Therapy ◽

Trial Design ◽

Clinical Trial Design ◽

Pooled Analysis ◽

Single Center

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Clinical, neuroradiological, diagnostic and prognostic profile of autoimmune glial fibrillary acidic protein astrocytopathy: A pooled analysis of 324 cases from published data and a single-center retrospective study

Journal of Neuroimmunology ◽

10.1016/j.jneuroim.2021.577718 ◽

2021 ◽

pp. 577718

Author(s):

Jun Xiao ◽

Xin Chen ◽

Ke Shang ◽

Yue Tang ◽

Man Chen ◽

...

Keyword(s):

Retrospective Study ◽

Glial Fibrillary Acidic Protein ◽

Pooled Analysis ◽

Acidic Protein ◽

Published Data ◽

Single Center ◽

Prognostic Profile

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Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

10.20944/preprints202001.0213.v1 ◽

2020 ◽

Author(s):

Elise Goetschalkx ◽

Djalila Mekahli ◽

Elena Levtchenko ◽

Karel Allegaert

Keyword(s):

Glomerular Filtration Rate ◽

Birth Weight ◽

Low Birth Weight ◽

Cohort Studies ◽

Filtration Rate ◽

Pooled Analysis ◽

Case Control ◽

Pediatric Age ◽

Single Center ◽

Age Range

Different cohort studies documented a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, <1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3-20.7 years). The majority were small (17-78 cases) single center studies, with heterogeneity in GFR measurement (inulin, Cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (ml/kg/1.73m2) within case-control studies was consistently lower (-13, range -8 to -25%) in cases, so that a relevant minority (15-30%) has a eGFR<90 mgl/kg/1.73m2). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size, and heterogeneity of GFR assessment tools.

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Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17062144 ◽

2020 ◽

Vol 17 (6) ◽

pp. 2144 ◽

Cited By ~ 1

Author(s):

Elise Goetschalckx ◽

Djalila Mekahli ◽

Elena Levtchenko ◽

Karel Allegaert

Keyword(s):

Glomerular Filtration Rate ◽

Birth Weight ◽

Low Birth Weight ◽

Cohort Studies ◽

Filtration Rate ◽

Pooled Analysis ◽

Case Control ◽

Pediatric Age ◽

Single Center ◽

Age Range

Various cohort studies document a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, <1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3–20.7 years). The majority were small (17–78 cases) single center studies, with heterogeneity in GFR measurement (inulin, cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (mL/min/1.73 m2) within case-control studies was consistently lower (−13%, range −8% to −25%) in cases, so that a relevant minority (15–30%) has a eGFR<90 mL/min/1.73 m2). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size and heterogeneity of GFR assessment tools.

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