Relation of fasting plasma peptide YY to glucose metabolism and cardiovascular risk factors after restrictive bariatric surgery

Background: The association between obesity and a reduction in life expectancy is well established, and cardiovascular disease is a leading cause of mortality. Bariatric surgery has long been established as the most effective and durable intervention for obesity, and is the only intervention for obesity that consistently improves multiple comorbidities, reduces cardiovascular disease and long-term mortality. The purpose of this review article is to describe the impact of metabolic/bariatric surgery on type 2 diabetes mellitus and cardiometabolic parameters, including cardiovascular mortality. Methods: A systematic literature search of Pubmed, MEDLINE, and Cochrane Central Register was performed. We included randomized controlled trials, metanalysis, case-control trials, and cohort studies that contain data on reductions in cardiovascular risk factors and cardiovascular mortality in subjects who underwent metabolic/bariatric surgery from January 1, 2005, to June 1, 2020. Conclusion: There is sufficient evidence of randomized controlled trials that metabolic/bariatric surgery is associated with a significant improvement of all cardiovascular risk factors. Although studies are showing a reduction of macrovascular events and cardiovascular mortality, these findings come from observational studies and should be confirmed in randomized clinical trials.

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The effect of surgery on fat mass, lipid and glucose metabolism in mild primary hyperparathyroidism

Endocrine Connections ◽

10.1530/ec-18-0259 ◽

2018 ◽

Vol 7 (8) ◽

pp. 941-948 ◽

Cited By ~ 3

Author(s):

Kristin Godang ◽

Karolina Lundstam ◽

Charlotte Mollerup ◽

Stine Lyngvi Fougner ◽

Ylva Pernow ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Glucose Metabolism ◽

Primary Hyperparathyroidism ◽

Cardiovascular Risk Factors ◽

Outcome Measures ◽

Fat Mass ◽

Lipid Lowering ◽

Mild Primary Hyperparathyroidism ◽

Over Time

Context Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors. Objective To assess the effect of parathyroidectomy on fat mass, glucose and lipid metabolism. Design, patients, interventions, main outcome measures 119 patients previously randomized to observation (OBS; n = 58) or parathyroidectomy (PTX; n = 61) within the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH) trial, an open randomized multicenter study, were included. Main outcome measures for this study were the differences in fat mass, markers for lipid and glucose metabolism between OBS and PTX 5 years after randomization. Results In the OBS group, total cholesterol (Total-C) decreased from mean 5.9 (±1.1) to 5.6 (±1.0) mmol/L (P = 0.037) and LDL cholesterol (LDL-C) decreased from 3.7 (±1.0) to 3.3 (±0.9) mmol/L (P = 0.010). In the PTX group, the Total-C and LDL-C remained unchanged resulting in a significant between-group difference over time (P = 0.013 and P = 0.026, respectively). This difference was driven by patients who started with lipid-lowering medication during the study period (OBS: 5; PTX: 1). There was an increase in trunk fat mass in the OBS group, but no between-group differences over time. Mean 25(OH) vitamin D increased in the PTX group (P < 0.001), but did not change in the OBS group. No difference in parameters of glucose metabolism was detected. Conclusion In mild PHPT, the measured metabolic and cardiovascular risk factors were not modified by PTX. Observation seems safe and cardiovascular risk reduction should not be regarded as a separate indication for parathyroidectomy based on the results from this study.

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Bariatric Surgery‐Induced Changes in Intima‐Media Thickness and Cardiovascular Risk Factors in Class 3 Obesity: A 3‐Year Follow‐Up Study

Obesity ◽

10.1002/oby.22905 ◽

2020 ◽

Vol 28 (9) ◽

pp. 1663-1670

Author(s):

Blanca Domenech‐Ximenos ◽

Victor Cuba ◽

Pepus Daunis‐i‐Estadella ◽

Santiago Thió‐Henestrosa ◽

Francisco Jaldo ◽

...

Keyword(s):

Risk Factors ◽

Bariatric Surgery ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Intima Media Thickness ◽

Follow Up Study ◽

Media Thickness ◽

Induced Changes

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Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women

Journal of Endocrinological Investigation ◽

10.1007/bf03344160 ◽

2006 ◽

Vol 29 (7) ◽

pp. 613-618 ◽

Cited By ~ 34

Author(s):

E. J. Rhee ◽

K. W. Oh ◽

E. J. Yun ◽

C. H. Jung ◽

W. Y. Lee ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Glucose Metabolism ◽

Cardiovascular Risk Factors ◽

Korean Women ◽

Klotho Gene ◽

Exon 4

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Assessment and management of severely obese children and adolescents

Archives of Disease in Childhood ◽

10.1136/archdischild-2015-309103 ◽

2016 ◽

Vol 101 (12) ◽

pp. 1161-1167 ◽

Cited By ~ 15

Author(s):

Neil Wright ◽

Jerry Wales

Keyword(s):

Risk Factors ◽

Bariatric Surgery ◽

Cardiovascular Risk ◽

Children And Adolescents ◽

Cardiovascular Risk Factors ◽

Severe Obesity ◽

Therapeutic Interventions ◽

Obese Children ◽

Severely Obese ◽

The Uk

Approximately 3% of children and adolescents in the UK have severe obesity. The incidence of cardiovascular risk factors such as hypertension, hyperinsulinism and hyperlipidaemia approaches 20% in such individuals. Lifestyle intervention programmes and pharmacotherapy are effective in some individuals, but the relapse rate is high. In exceptional cases, bariatric surgery is effective. This review outlines the scale of the problem, highlights those at risk and discusses referral, current services, appropriate screening and therapeutic interventions.

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