Understanding adolescents’ and young adults’ self-perceptions after cancer treatment in the context of a two-arm, mixed-methods pilot randomized controlled physical activity trial

2021 ◽  
Author(s):  
Amanda Wurz ◽  
Jenson Price ◽  
Jennifer Brunet
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Mixed Methods ◽  
Cancer Treatment ◽  
Adolescents And Young Adults ◽  
Self Perceptions ◽  
Randomized Controlled ◽  
After Cancer

scholarly journals A proof-of-concept sub-study exploring feasibility and preliminary evidence for the role of physical activity on neural activity during executive functioning tasks among young adults after cancer treatment

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Amanda Wurz ◽  
Gladys Ayson ◽  
Andra M. Smith ◽  
Jennifer Brunet
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Executive Functioning ◽  
Cancer Treatment ◽  
Task Performance ◽  
Neural Activity ◽  
Preliminary Evidence ◽  
Proof Of Concept ◽  
Information Encoding ◽  
After Cancer

Abstract Background Executive functioning (EF) deficits are troubling for adolescents and young adults (AYAs) after cancer treatment. Physical activity (PA) may enhance neural activity underlying EF among older adults affected by cancer. Establishing whether PA enhances neural activity among AYAs is warranted. As part of a two-arm, mixed-methods pilot randomized controlled trial (RCT), this proof-of-concept sub-study sought to answer the following questions: (1) is it feasible to use neuroimaging with EF tasks to assess neural activity changes following a 12-week PA intervention? And (2) is there preliminary evidence that a 12-week PA intervention enhances neural activity among AYAs after cancer treatment? Methods AYAs in the pilot RCT were approached for enrollment into this sub-study. Those who were eligible and enrolled, completed functional magnetic resonance imaging (fMRI) with EF tasks (letter n-back, Go/No Go) pre- and post-PA intervention. Sub-study enrollment, adherence to scheduled fMRI scans, outliers, missing data, and EF task performance data were collected. Data were analyzed with descriptive statistics, blood oxygen level dependent (BOLD) analyses, and paired sample t-tests. Results Nine eligible participants enrolled into this sub-study; six attended scheduled fMRI scans. One outlier was identified and was subsequently removed from the analytical sample. Participants showed no differences in EF task performance from pre- to post-PA intervention. Increases in neural activity in brain regions responsible for motor control, information encoding and processing, and decision-making were observed post-PA intervention (p < 0.05; n = 5). Conclusions Findings  show that fMRI scans during EF tasks detected neural activity changes (as assessed by the BOLD signal) from pre- to post-PA intervention. Results thus suggest future trials confirming that PA enhances neural activity underlying EF are needed, though feasibility issues require careful consideration to ensure trial success. Trial registration clinicaltrials.gov, NCT03016728. Registered January 11, 2017, clinicaltrials.gov/ct2/show/NCT03016728.

scholarly journals Sexual Activity and Substance Use Among Adolescents and Young Adults Receiving Cancer Treatment: A Report from the PRISM Randomized Controlled Trial

2020 ◽  
Vol 9 (5) ◽  
pp. 594-600 ◽  
Author(s):  
Kaitlyn M. Fladeboe ◽  
Samantha Scott ◽  
Miranda C. Bradford ◽  
Tyler G. Ketterl ◽  
Joyce P. Yi-Frazier ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Substance Use ◽  
Young Adults ◽  
Cancer Treatment ◽  
Sexual Activity ◽  
Controlled Trial ◽  
Adolescents And Young Adults ◽  
Randomized Controlled

scholarly journals A web-based intervention to promote physical activity in adolescents and young adults with cystic fibrosis: protocol for a randomized controlled trial

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Narelle S. Cox ◽  
◽  
Beverley Eldridge ◽  
Sarah Rawlings ◽  
Julianna Dreger ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Randomized Controlled Trial ◽  
Young Adults ◽  
Controlled Trial ◽  
Adolescents And Young Adults ◽  
Physical Activity Participation ◽  
Activity Participation ◽  
Web Based ◽  
Randomized Controlled

Abstract Background Regular participation in physical activity by people with cystic fibrosis (CF) promotes positive clinical and health outcomes including reduced rate of decline in lung function, fewer hospitalizations and greater wellbeing. However adherence to exercise and activity programs is low, in part due to the substantial daily therapy burden for young people with CF. Strict infection control requirements limit the role of group exercise programs that are commonly used in other clinical groups. Investigation of methods to promote physical activity in this group has been limited. The Active Online Physical Activity in Cystic fibrosis Trial (ActionPACT) is an assessor-blinded, multi-centre, randomized controlled trial designed to compare the efficacy of a novel web-based program (ActivOnline) compared to usual care in promoting physical activity participation in adolescents and young adults with CF. Methods Adolescents and young adults with CF will be recruited on discharge from hospital for a respiratory exacerbation. Participants randomized to the intervention group will have access to a web-based physical activity platform for the 12-week intervention period. ActivOnline allows users to track their physical activity, set goals, and self-monitor progress. All participants in both groups will be provided with standardised information regarding general physical activity recommendations for adolescents and young adults. Outcomes will be assessed by a blinded assessor at baseline, after completion of the intervention, and at 3-months followup. Healthcare utilization will be assessed at 12 months from intervention completion. The primary outcome is change in moderate-to-vigorous physical activity participation measured objectively by accelerometry. Secondary outcomes include aerobic fitness, health-related quality of life, anxiety and depression and sleep quality. Discussion This trial will establish whether a web-based application can improve physical activity participation more effectively than usual care in the period following hospitalization for a respiratory exacerbation. The web-based application under investigation can be made readily and widely available to all individuals with CF, to support physical activity and exercise participation at a time and location of the user’s choosing, regardless of microbiological status. Trial registration Clinical trial registered on July 13, 2017 with the Australian and New Zealand Clinical Trials Register at (ACTRN12617001009303).

Sleep in Adolescents and Young Adults in the Year After Cancer Treatment

2017 ◽  
Vol 6 (4) ◽  
pp. 560-567 ◽  
Author(s):  
Lauren C. Daniel ◽  
Richa Aggarwal ◽  
Lisa A. Schwartz
Keyword(s):  
Young Adults ◽  
Cancer Treatment ◽  
Adolescents And Young Adults ◽  
After Cancer

scholarly journals Cancer-Related Fatigue in Adolescents and Young Adults After Cancer Treatment: Persistent and Poorly Managed

2017 ◽  
Vol 6 (3) ◽  
pp. 489-493 ◽  
Author(s):  
Anna Spathis ◽  
Helen Hatcher ◽  
Sara Booth ◽  
Faith Gibson ◽  
Paddy Stone ◽  
...  
Keyword(s):  
Young Adults ◽  
Cancer Treatment ◽  
Adolescents And Young Adults ◽  
Cancer Related Fatigue ◽  
After Cancer

Needs of adolescents and young adults after cancer treatment: a systematic review

2016 ◽  
Vol 27 (6) ◽  
pp. e12558 ◽  
Author(s):  
S. Galán ◽  
R. de la Vega ◽  
J. Miró
Keyword(s):  
Systematic Review ◽  
Young Adults ◽  
Cancer Treatment ◽  
Adolescents And Young Adults ◽  
After Cancer

scholarly journals The Use of AMH to Assess Ovarian Toxicity in Adolescents and Young Adults After Cancer Treatment

2020 ◽  
Vol 105 (8) ◽  
pp. e3006-e3007
Author(s):  
Richard A Anderson ◽  
W Hamish B Wallace
Keyword(s):  
Young Adults ◽  
Cancer Treatment ◽  
Adolescents And Young Adults ◽  
Ovarian Toxicity ◽  
After Cancer

A randomized controlled trial of a structured exercise intervention after the completion of acute cancer treatment in adolescents and young adults

2020 ◽  
Vol 68 (1) ◽  
Author(s):  
Morgan Atkinson ◽  
Andrew Murnane ◽  
Thomas Goddard ◽  
Cathy Pendergrast ◽  
Paul Rogers ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Young Adults ◽  
Cancer Treatment ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Adolescents And Young Adults ◽  
Randomized Controlled
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