Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer

2001 ◽  
Vol 36 (12) ◽  
pp. 823-829 ◽  
Author(s):  
Katsuki Ito ◽  
ChunLin Ye ◽  
Kenji Hibi ◽  
Chikako Mitsuoka ◽  
Reiji Kannagi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Marker ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Soluble E Selectin ◽  
Lewis A

scholarly journals Influence of Lewis α1-3/4-L-Fucosyltransferase (FUT3) Gene Mutations on Enzyme Activity, Erythrocyte Phenotyping, and Circulating Tumor Marker Sialyl-Lewis a Levels

1996 ◽  
Vol 271 (50) ◽  
pp. 32260-32268 ◽  
Author(s):  
Torben F. Ørntoft ◽  
Else Marie Vestergaard ◽  
Eric Holmes ◽  
Jørn Sinkbæk Jakobsen ◽  
Niels Grunnet ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Tumor Marker ◽  
Gene Mutations ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis A

Die Expression von Sialyl Lewis A, Sialyl Lewis X, Lewis Y und Thomsen-Friedenreich Antigen in zervikalen Dysplasien und invasiven Zervixkarzinomen

2011 ◽  
Vol 71 (05) ◽  
Author(s):  
V Engelstaedter ◽  
B Fluegel ◽  
S Kunze ◽  
F Bergauer ◽  
D Mayr ◽  
...  
Keyword(s):  
Sialyl Lewis X ◽  
Lewis X ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis Y ◽  
Lewis A

scholarly journals Discovery of sialyl Lewis A and Lewis X modified protein cancer biomarkers using high density antibody arrays

2014 ◽  
Vol 96 ◽  
pp. 291-299 ◽  
Author(s):  
Jung-hyun Rho ◽  
Judson R. Mead ◽  
W. Shea Wright ◽  
Dean E. Brenner ◽  
James W. Stave ◽  
...  
Keyword(s):  
Cancer Biomarkers ◽  
High Density ◽  
Lewis X ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Antibody Arrays ◽  
Lewis A

Abstract B122: Human monoclonal antibodies to sialyl‐Lewis‐A with potent CDC and ADCC activity

2009 ◽  
Author(s):  
Ritsuko Sawada ◽  
Shu‐Man Sun ◽  
Feng Hong ◽  
Govind Ragupathi ◽  
Philip O. Livingston ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Adcc Activity ◽  
Human Monoclonal Antibodies ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis A

scholarly journals SSEA3 and Sialyl Lewis a Glycan Expression Is Controlled by B3GALT5 LTR through Lamin A-NFYA and SIRT1-STAT3 Signaling in Human ES Cells

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 177
Author(s):  
Bi-He Cai ◽  
Hsueh-Yi Lee ◽  
Chi-Kan Chou ◽  
Po-Han Wu ◽  
Hsiang-Chi Huang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Es Cells ◽  
Lamin A ◽  
Es Cell ◽  
Stat3 Signaling ◽  
Sialyl Lewis ◽  
Human Es Cells ◽  
Sialyl Lewis A ◽  
Ltr Promoter ◽  
Lewis A

B3GALT5 is involved in the synthesis of embryonic stem (ES) cell marker glycan, stage-specific embryonic antigen-3 (SSEA3). This gene has three native promoters and an integrated retroviral long terminal repeat (LTR) promoter. We found that B3GALT5-LTR is expressed at high levels in human ES cells. B3GALT5-LTR is also involved in the synthesis of the cancer-associated glycan, sialyl Lewis a. Sialyl Lewis a is expressed in ES cells and its expression decreases upon differentiation. Retinoic acid induced differentiation of ES cells, decreased the short form of NFYA (NFYAs), increased phosphorylation of STAT3, and decreased B3GALT5-LTR expression. NFYAs activated, and constitutively-active STAT3 (STAT3C) repressed B3GALT5-LTR promoter. The NFYAs and STAT3C effects were eliminated when their binding sites were deleted. Retinoic acid decreased the binding of NFYA to B3GALT5-LTR promoter and increased phospho-STAT3 binding. Lamin A repressed NFYAs and SSEA3 expression. SSEA3 repression mediated by a SIRT1 inhibitor was reversed by a STAT3 inhibitor. Repression of SSEA3 and sialyl Lewis a synthesis mediated by retinoic acid was partially reversed by lamin A short interfering RNA (siRNA) and a STAT3 inhibitor. In conclusion, B3GALT5-LTR is regulated by lamin A-NFYA and SIRT1-STAT3 signaling that regulates SSEA3 and sialyl Lewis a synthesis in ES cells, and sialyl Lewis a is also a ES cell marker.

ChemInform Abstract: A Sialyl-Lewis A-Asparagine Building Block for Glycopeptide-Synthesis.

ChemInform ◽  
2000 ◽  
Vol 31 (40) ◽  
pp. no-no
Author(s):  
Karen Peilstoecker ◽  
Horst Kunz
Keyword(s):  
Building Block ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis A

scholarly journals Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers

Biology ◽  
2017 ◽  
Vol 6 (4) ◽  
pp. 16 ◽  
Author(s):  
Marco Trinchera ◽  
Adele Aronica ◽  
Fabio Dall’Olio
Keyword(s):  
Sialyl Lewis X ◽  
Gastrointestinal Cancers ◽  
Lewis X ◽  
Sialyl Lewis ◽  
Selectin Ligands ◽  
Sialyl Lewis A ◽  
Lewis A
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