CYP 17 and estrogen receptor α gene polymorphisms: association with breast cancer susceptibility and clinicopathological parameters in a cohort of Egyptian patients

2013 ◽  
Vol 23 (5) ◽  
pp. 1609-1617
Author(s):  
Nadida Gohar ◽  
Dina El Gayar ◽  
Marianne Samir M. Issac ◽  
Mohammed Shehata ◽  
Yasmine Khater ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Gene Polymorphisms ◽  
Cancer Susceptibility ◽  
Estrogen Receptor Α ◽  
Breast Cancer Susceptibility ◽  
Clinicopathological Parameters ◽  
Egyptian Patients ◽  
Estrogen Receptor Α Gene

scholarly journals The Breast Cancer Susceptibility Gene BRCA1 Regulates Progesterone Receptor Signaling in Mammary Epithelial Cells

2006 ◽  
Vol 20 (1) ◽  
pp. 14-34 ◽  
Author(s):  
Yongxian Ma ◽  
Pragati Katiyar ◽  
Laundette P. Jones ◽  
Saijun Fan ◽  
Yiyu Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Cancer Susceptibility ◽  
Susceptibility Gene ◽  
Estrogen Receptor Α ◽  
Breast Cancer Susceptibility ◽  
Breast Cancer Susceptibility Gene ◽  
Wild Type ◽  
Cancer Susceptibility Gene

Abstract The progesterone receptor (PR) plays roles in normal mammary development and breast cancer formation, where it may exert both stimulatory and inhibitory actions. Previously, the breast cancer susceptibility gene product BRCA1 was found to interact with and inhibit the transcriptional activity of estrogen receptor-α. In this study, we found that exogenous wild-type BRCA1 inhibited the activity of the PR in transient transfection assays utilizing a mouse mammary tumor virus-Luc reporter. Wild-type BRCA1 inhibited the activity of endogenous PR in human breast cancer cells (T47D and MCF-7) and inhibited the activity of exogenous PR-A, PR-B, and [PR-A plus PR-B] isoforms. On the other hand, knockdown of endogenous BRCA1 using small interfering RNA enhanced the progesterone-stimulated activity of the PR by about 4-fold. We documented an in vivo association of the endogenous BRCA1 with PR isoforms A and B and a direct in vitro interaction between BRCA1 and PR, which was partially mapped. Whereas down-regulation of the coactivator p300 contributes to the BRCA1-mediated repression of estrogen receptor-α, this mechanism does not contribute to inhibition of PR activity, because exogenous p300 did not rescue the BRCA1 repression of PR activity. The BRCA1-PR interaction has functional consequences. Thus, we showed that BRCA1 inhibits the expression of various endogenous progesterone-responsive genes and inhibits progesterone-stimulated proliferation of T47D cells. Finally, exogenous progesterone caused an exaggerated proliferative response in the mammary glands of mice harboring a mammary-targeted conditional deletion of the full-length isoform of Brca1. These findings suggest that BRCA1 regulates the activity of progesterone, a major hormone of pregnancy that may also participate in mammary carcinogenesis.

Estrogen Receptor α Gene Polymorphisms and Bone Mineral Density in Healthy Children and Young Adults

2004 ◽  
Vol 74 (6) ◽  
pp. 495-500 ◽  
Author(s):  
A. M. Boot ◽  
I. M. van der Sluis ◽  
S. M. P. F. de Muinck Keizer-Schrama ◽  
J. B. J. van Meurs ◽  
E. P. Krenning ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Young Adults ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Healthy Children ◽  
Mineral Density ◽  
Children And Young Adults ◽  
Estrogen Receptor Α Gene

Association between estrogen receptor-α gene polymorphisms and dermatomyositis in Bulgarian patients

2014 ◽  
Vol 53 (7) ◽  
pp. e363-e364 ◽  
Author(s):  
Lyubomir Dourmishev ◽  
Zornitsa Kamenarska ◽  
Radka Kaneva ◽  
Vanio Mitev ◽  
Maria Hristova ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

scholarly journals Preliminary genetic imaging study of the association between estrogen receptor-α gene polymorphisms and harsh human maternal parenting

2012 ◽  
Vol 525 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Benjamin B. Lahey ◽  
Kalina J. Michalska ◽  
Chunyu Liu ◽  
Qi Chen ◽  
Alison E. Hipwell ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Gene Polymorphisms ◽  
Imaging Study ◽  
Estrogen Receptor Α ◽  
Maternal Parenting ◽  
Estrogen Receptor Α Gene ◽  
Genetic Imaging

Cytokine Gene Polymorphisms and Breast Cancer Susceptibility

2006 ◽  
Vol 1089 (1) ◽  
pp. 104-109 ◽  
Author(s):  
L. SCOLA ◽  
M. VAGLICA ◽  
A. CRIVELLO ◽  
L. PALMERI ◽  
G. I. FORTE ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphisms ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

The Estrogen Receptor α Gene and Breast Cancer Risk (The Netherlands)

2005 ◽  
Vol 16 (10) ◽  
pp. 1195-1202 ◽  
Author(s):  
N. Charlotte Onland-Moret ◽  
Carla H. van Gils ◽  
Mark Roest ◽  
Diederick E. Grobbee ◽  
Petra H. M. Peeters
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
The Netherlands ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

scholarly journals Lack of an Association of Estrogen Receptor α Gene Polymorphisms and Transcriptional Activity With Alzheimer Disease

2000 ◽  
Vol 57 (2) ◽  
pp. 236 ◽  
Author(s):  
Hirofumi Maruyama ◽  
Hiromasa Toji ◽  
Charles R. Harrington ◽  
Ken Sasaki ◽  
Yuishin Izumi ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Alzheimer Disease ◽  
Gene Polymorphisms ◽  
Transcriptional Activity ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

Estrogen Receptor α Gene Polymorphisms Are Associated With Idiopathic Premature Ovarian Failure

2008 ◽  
Vol 63 (7) ◽  
pp. 435-436
Author(s):  
Karla L. Bretherick ◽  
Courtney W. Hanna ◽  
Lauren M. Currie ◽  
Margo R. Fluker ◽  
Geoffrey L. Hammond ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Premature Ovarian Failure ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Ovarian Failure ◽  
Estrogen Receptor Α Gene
Sign in / Sign up

Export Citation Format

Share Document