Some haematological parameters of albino mice experimentally inoculated with Trypanosoma brucei brucei after administration of Halofantrine hydrochloride, chloroquine and diaminazine aceturate

2017 ◽  
Vol 26 (4) ◽  
pp. 935-941
Author(s):  
Ijeoma Agbo ◽  
Chukwuebuka Iniobong Ikenna Ugochukwu ◽  
Emmanuel Ikenna Ugochukwu ◽  
Denchris Nnabuike Onah ◽  
Kingsley Tochukwu Ughamba
Keyword(s):  
Trypanosoma Brucei ◽  
Haematological Parameters ◽  
Trypanosoma Brucei Brucei ◽  
Albino Mice

Comparative effects of graded doses of diaminanzine ace-turate and fixed doses of levamisole in the treatment of albino mice experimentally infected with Trypanosoma brucei brucei

2016 ◽  
Vol 2 (1) ◽  
pp. 59-70
Author(s):  
Michael K. Ijomanta ◽  
Chukwuebuka I. Ugochukwu ◽  
Emmanuel I. Ugochukwu
Keyword(s):  
Body Weight ◽  
Trypanosoma Brucei ◽  
Rectal Temperature ◽  
Untreated Control ◽  
Haemoglobin Concentration ◽  
Post Treatment ◽  
Fixed Dose ◽  
Trypanosoma Brucei Brucei ◽  
Albino Mice ◽  
Group D

Trypanosomosis is a widespread and important disease of animals and humans in tsetse-infested areas of Africa, Nigeria inclusive. To investigate the comparative effects of graded doses of Diaminazine aceturate (DA) and fixed doses of Levamisole in the treatment of albino mice experimentally infected with field isolates of Trypanosoma brucei brucei. Thirty adult mice were used and were randomly divided into 6 groups of 5 mice each. After infection has been established, 3 groups (A, B and C) were treated with graded doses of DA at 7, 14 and 21mg/kg body weight respectively and a fixed dose of Levamisole at 7.5mg/kg body weight, whereas group D was treated with Levamisole only at the same dose.  Group E served as positive (infected untreated) control while group F served a negative (uninfected untreated) control. The following parameters were used to access the efficacy of the drugs: weekly rectal temperature, weight changes, packed cell volume, haemoglobin concentration, clinical signs or survivabilty and parasitaemia. The parasite cleared from groups A, B and C by the 48th hour post treatment, but remained in group D while all the mice in group E died within 65 days PI, those in group D died within 65 days PI, whereas those in Group D died within 35 days post treatment. Relapse infection was only recorded in group A at day 30 post treatment. There was no relapse in group B and C, but more deaths were recorded in group C. The significant reduction (p<0.05) in the weight, PCV and haemoglobin concentration and an increase in rectal temperature following infection was reversed by the treatments in groups A, B and C. The results obtained show that an increased dose of DA at 14mg/kg body weight and Levamisole at 7.5mg/kg body weight proved most effective in the treatment of clinical cases of infection with Trypanosoma brucei brucei.

Effects of n-hexane and ethylacetate fractions of Terminalia catappa leaf extract in experimental Trypanosoma brucei brucei infection in Wistar rats

2021 ◽  
Author(s):  
Folashade Sarah Ojeleye ◽  
Helen Ileigo Inabo ◽  
Clement Myah Zaman Whong ◽  
Bolanle Olufunke Priscilla Musa ◽  
Ochuko Orakpoghenor
Keyword(s):  
Trypanosoma Brucei ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Trypanosoma Brucei Brucei ◽  
Terminalia Catappa

Modulation of Early Immune Responses and Suppression of Trypanosoma brucei brucei Infections by Surgical Denervation of the Spleen

2000 ◽  
Vol 8 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Yajuan Liu ◽  
Manal Mustafa ◽  
Hu-Lun Li ◽  
Lauri Nuortio ◽  
Amged Mustafa ◽  
...  
Keyword(s):  
Immune Responses ◽  
Trypanosoma Brucei ◽  
Trypanosoma Brucei Brucei
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