Clinical and radiographic outcomes of concentrated bone marrow aspirate with allograft and demineralized bone matrix for posterolateral and interbody lumbar fusion in elderly patients

2015 ◽  
Vol 24 (11) ◽  
pp. 2567-2572 ◽  
Author(s):  
Remi M. Ajiboye ◽  
Jason T. Hamamoto ◽  
Mark A. Eckardt ◽  
Jeffrey C. Wang
Keyword(s):  
Bone Marrow ◽  
Elderly Patients ◽  
Bone Marrow Aspirate ◽  
Demineralized Bone Matrix ◽  
Lumbar Fusion ◽  
Bone Matrix ◽  
Radiographic Outcomes ◽  
Concentrated Bone Marrow ◽  
Demineralized Bone

scholarly journals Outcomes of Demineralized Bone Matrix Enriched with Concentrated Bone Marrow Aspirate in Lumbar Fusion

10.14444/3035 ◽  
2016 ◽  
Vol 10 ◽  
pp. 35 ◽  
Author(s):  
Remi M. Ajiboye ◽  
Mark A. Eckardt ◽  
Jason T. Hamamoto ◽  
Benjamin Plotkin ◽  
Michael D. Daubs ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Demineralized Bone Matrix ◽  
Lumbar Fusion ◽  
Bone Matrix ◽  
Concentrated Bone Marrow ◽  
Demineralized Bone

Does Age Influence the Efficacy of Demineralized Bone Matrix Enriched with Concentrated Bone Marrow Aspirate in Lumbar Fusions?

2018 ◽  
Vol 31 (1) ◽  
pp. E30-E35 ◽  
Author(s):  
Remi M. Ajiboye ◽  
Mark A. Eckardt ◽  
Jason T. Hamamoto ◽  
Akshay Sharma ◽  
Adam Z. Khan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Concentrated Bone Marrow ◽  
Demineralized Bone

scholarly journals Injection of Unicameral Bone Cysts with Bone Marrow Aspirate and Demineralized Bone Matrix Avoids Open Curettage and Bone Grafting in a Retrospective Cohort

2017 ◽  
Vol 11 (1) ◽  
pp. 486-492 ◽  
Author(s):  
Kenneth R. Gundle ◽  
Etasha M. Bhatt ◽  
Stephanie E. Punt ◽  
Viviana Bompadre ◽  
Ernest U. Conrad
Keyword(s):  
Bone Marrow ◽  
Bone Grafting ◽  
Retrospective Cohort ◽  
Bone Marrow Aspirate ◽  
Proximal Humerus ◽  
Demineralized Bone Matrix ◽  
Academic Medical Center ◽  
Bone Matrix ◽  
Bone Cysts ◽  
Demineralized Bone

Background:Many treatment options exist for unicameral bone cysts (UBC), without clear evidence of superiority. Meta-analyses have been limited by small numbers of patients in specific anatomic and treatment subgroups. The purpose of this study was to report the outcomes of injecting bone marrow aspirate and demineralized bone matrix (BMA/DBM) for the treatment of proximal humerus UBC.Methods:Fifty-one patients with proximal humerus lesions treated by BMA/DBM injection were retrospectively reviewed from a single academic medical center.Results:The mean number of injections performed per patient was 2.14 (range 1-5). Eleven patients underwent only one injection (22%), an additional 19 patients completed treatment after two injections (37%), four patients healed after three injections (8%), and one patient healed after four injections (2%). The cumulative success rate of serial BMA/DBM injections was 22% (11/51), 58% (30/51), 67% (34/51), and 69% (35/51). Eleven patients (22%) ultimately underwent open curettage and bone grafting, and five patients (10%) were treated with injection of calcium phosphate bone substitute.Conclusion:A BMA/DBM injection strategy avoided an open procedure in 78% of patients with a proximal humerus UBC. The majority of patients underwent at least 2 injection treatments.Level of Evidence:Level IV retrospective cohort study.

Grafting Long Bone Fractures With Demineralized Bone Matrix Putty Enriched With Bone Marrow: Pilot Findings

Orthopedics ◽  
2006 ◽  
Vol 29 (10) ◽  
pp. 939-941 ◽  
Author(s):  
Ronald W. Lindsey ◽  
Kalia K. Sadasivian ◽  
George W. Wood ◽  
Harrison A. Stubbs ◽  
Jon E. Block
Keyword(s):  
Bone Marrow ◽  
Bone Fractures ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Long Bone ◽  
Long Bone Fractures ◽  
Demineralized Bone

Demineralized bone matrix-based microcarrier scaffold favors vascularized large bone regeneration in vivo in a rat model

2018 ◽  
Vol 33 (2) ◽  
pp. 182-195 ◽  
Author(s):  
Qiannan Li ◽  
Wenjie Zhang ◽  
Guangdong Zhou ◽  
Yilin Cao ◽  
Wei Liu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Stem Cells ◽  
Bone Marrow ◽  
Bone Regeneration ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Matrix Group ◽  
Micro Computed Tomography ◽  
Demineralized Bone

Insufficient neo-vascularization of in vivo implanted cell-seeded scaffold remains a major bottleneck for clinical translation of engineered bone formation. Demineralized bone matrix is an ideal bone scaffold for bone engineering due to its structural and biochemical components similar to those of native bone. We hypothesized that the microcarrier form of demineralized bone matrix favors ingrowth of vessels and bone regeneration upon in vivo implantation. In this study, a rat model of femoral vessel pedicle-based bone engineering was employed by filling the demineralized bone matrix scaffolds inside a silicone chamber that surrounded the vessel pedicles, and to compare the efficiency of vascularized bone regeneration between microcarrier demineralized bone matrix and block demineralized bone matrix. The results showed that bone marrow stem cells better adhered to microcarrier demineralized bone matrix and produced more extracellular matrices during in vitro culture. After in vivo implantation, microcarrier demineralized bone matrix seeded with bone marrow stem cells formed relatively more bone tissue than block demineralized bone matrix counterpart at three months upon histological examination. Furthermore, micro-computed tomography three-dimensional reconstruction showed that microcarrier demineralized bone matrix group regenerate significantly better and more bone tissues than block demineralized bone matrix both qualitatively and quantitatively (p < 0.05). Moreover, micro-computed tomography reconstructed angiographic images also demonstrated significantly enhanced tissue vascularization in microcarrier demineralized bone matrix group than in block demineralized bone matrix group both qualitatively and quantitatively (p < 0.05). Anti-CD31 immunohistochemical staining of (micro-) vessels and semi-quantitative analysis also evidenced enhanced vascularization of regenerated bone in microcarrier demineralized bone matrix group than in block demineralized bone matrix group (p < 0.05). In conclusion, the microcarrier form of demineralized bone matrix is an ideal bone regenerative scaffold due to its advantages of osteoinductivity and vascular induction, two essentials for in vivo bone regeneration.

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