Dabrafenib monotherapy for a recurrent BRAFV600E-mutated TTF-1-positive posterior pituitary tumor

2022 ◽  
Author(s):  
Flavie Grenier-Chartrand ◽  
Sami Barrit ◽  
Marie Lucie Racu ◽  
Sylvie Luce ◽  
Julien Spitaels ◽  
...  
Keyword(s):  
Pituitary Tumor ◽  
Posterior Pituitary

TTF-1 positive posterior pituitary tumor: Limitations of current treatment and potential new hope in BRAF V600E mutation variants

2020 ◽  
Vol 196 ◽  
pp. 106059
Author(s):  
Fakhry M. Dawoud ◽  
Ryan M. Naylor ◽  
Caterina Giannini ◽  
Amy A. Swanson ◽  
Fredric B. Meyer ◽  
...  
Keyword(s):  
Pituitary Tumor ◽  
Current Treatment ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Posterior Pituitary

scholarly journals PATH-36. SYNCHRONOUS TTF-1-POSITIVE TUMORS AND PITUITARY ADENOMAS. ARE WE SENDING INSUFFICIENT TUMOR TISSUE FOR PATHOLOGY?

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii172-ii172
Author(s):  
Franco Rubino ◽  
Daniel Eichberg ◽  
Ashish shah ◽  
Evan Luther ◽  
Victor Lu ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Cushing Syndrome ◽  
Case Reports ◽  
Case Series ◽  
Pituitary Tumors ◽  
World Health ◽  
Low Grade ◽  
Posterior Pituitary ◽  
Female Ratio

Abstract BACKGROUND Tumors of the posterior pituitary are a distinct group of low-grade neoplasms arising from the sellar region. According to the most recent World Health Organization (WHO) guidelines, these tumors are grouped based on TTF-1 immunostain positivity. The coexistence of a posterior and anterior pituitary tumors is statistically extremely unlikely. OBJECTIVE In this study, we present a case of a 41-year-old woman suffering from Cushing syndrome with the presence of two pituitary masses on MRI. Also, the relevant literature is systematically reviewed. METHODS Two databases (PubMed and Google Scholar) and crossed references were systematically reviewed for TTF-1 pituitary tumors with coexisting pituitary adenoma or increased pituitary serum hormone levels. A literature review was performed according to PRISMA guidelines. Also, one patient from our institution is reported. Data regarding demographic features, type of anterior and posterior pituitary tumor, clinical features of the patients and lab results, MRI findings, and pathology results were extracted. RESULTS Seventeen retrospective case reports and case series were identified and included. Twenty-four patients were analyzed (including the reported case). The mean age was 46 ± 16 years, with a male-to-female ratio of 0.33:1. Pituicytomas and granular cell tumors were the only posterior pituitary tumors reported in 19 (79%) and 5 (21%) cases, respectively. There are only eight cases reported (including our patient) with a confirmed pituitary adenoma and a TTF-1 pituitary tumor (one GCT with GH-secreting adenoma, five pituicytoma with ACTH-secreting adenoma, one with GH-secreting adenoma and one with a null type adenoma). CONCLUSION We presented the eighth reported case of a TTF-1 pituitary tumor coexisting with a pituitary adenoma. We think that improving the amount of the tissue specimen available for pathology evaluation could increase the incidence of these very rare tumors.

Combined Endoscopic Endonasal and Video-microscopic Transcranial Approach with Preoperative Embolization for a Posterior Pituitary Tumor

2018 ◽  
Vol 119 ◽  
pp. 201-208 ◽  
Author(s):  
Keisuke Yoshida ◽  
Masahiro Toda ◽  
Takenori Akiyama ◽  
Satoshi Takahashi ◽  
Masaaki Nishimoto ◽  
...  
Keyword(s):  
Pituitary Tumor ◽  
Preoperative Embolization ◽  
Posterior Pituitary ◽  
Endoscopic Endonasal ◽  
Transcranial Approach

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

Endoscopic Pituitary Tumor Surgery: The Learning Curve

2014 ◽  
Vol 75 (S 01) ◽  
Author(s):  
Amjad Anaizi ◽  
Christopher Taylor ◽  
Jennifer Kosty ◽  
Lee Zimmer ◽  
Philip Theodosopoulos
Keyword(s):  
Learning Curve ◽  
Pituitary Tumor ◽  
Tumor Surgery

Integration of stimulatory and inhibitory signals in pituitary tumor cells through the PI3 kinase pathway

2006 ◽  
Vol 114 (08) ◽  
Author(s):  
T Colaco ◽  
C Onofri ◽  
M Theodoropoulou ◽  
M Kowarik ◽  
GK Stalla ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Pituitary Tumor ◽  
Pi3 Kinase ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway
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