Primary kidney growth and its consequences at the onset of diabetes mellitus

Amino Acids ◽  
2006 ◽  
Vol 31 (1) ◽  
pp. 1-9 ◽  
Author(s):  
J. Satriano ◽  
V. Vallon
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Growth ◽  
Onset Of Diabetes

scholarly journals Nociceptin Increases Antioxidant Expression in the Kidney, Liver and Brain of Diabetic Rats

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 621
Author(s):  
Ernest Adeghate ◽  
Crystal M. D’Souza ◽  
Zulqarnain Saeed ◽  
Saeeda Al Jaberi ◽  
Saeed Tariq ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Rats ◽  
Enzyme Linked Immunosorbent Assay ◽  
Kidney Tubules ◽  
Onset Of Diabetes ◽  
Endogenous Antioxidants ◽  
Kidney Liver ◽  
Convoluted Tubules ◽  
The Brain

Nociceptin (NC) consists of 17 amino acids (aa) and takes part in the processing of learning and memory. The role of NC in the induction of endogenous antioxidants in still unclear. We examined the effect of NC on the expression of endogenous antioxidants in kidney, liver, cerebral cortex (CC), and hippocampus after the onset of diabetes mellitus, using enzyme-linked immunosorbent assay and immunohistochemistry. Exogenous NC (aa chain 1–17; 10 µg/kg body weight) was given intraperitoneally to normal and diabetic rats for 5 days. Our results showed that catalase (CAT) is present in the proximal (PCT) and distal (DCT) convoluted tubules of kidney, hepatocytes, and neurons of CC and hippocampus. The expression of CAT was significantly (p < 0.05) reduced in the kidney of normal and diabetic rats after treatment with NC. However, NC markedly (p < 0.001) increased the expression CAT in the liver and neurons of CC of diabetic rats. Superoxide dismutase (SOD) is widely distributed in the PCT and DCT of kidney, hepatocytes, and neurons of CC and hippocampus. NC significantly (p < 0.001) increased the expression of SOD in hepatocytes and neurons of CC and the hippocampus but not in the kidney. Glutathione reductase (GRED) was observed in kidney tubules, hepatocytes and neurons of the brain. NC markedly increased (p < 0.001) the expression of GRED in PCT and DCT cells of the kidney and hepatocytes of liver and neurons of CC. In conclusion, NC is a strong inducer of CAT, SOD, and GRED expression in the kidney, liver and brain of diabetic rats.

scholarly journals High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yukimura Higashiura ◽  
Masato Furuhashi ◽  
Marenao Tanaka ◽  
Satoko Takahashi ◽  
Masayuki Koyama ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Liver ◽  
Male And Female ◽  
Nonalcoholic Fatty Liver ◽  
Liver Index ◽  
Fatty Liver Index ◽  
History Of ◽  
Onset Of Diabetes ◽  
High Level ◽  
New Onset

AbstractFatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals.

Subjective well-being before and after the onset of diabetes mellitus

2005 ◽  
Vol 19 (2) ◽  
pp. 88-95 ◽  
Author(s):  
Siri Naess ◽  
John Eriksen ◽  
Kristian Midthjell ◽  
Kristian Tambs
Keyword(s):  
Diabetes Mellitus ◽  
Well Being ◽  
Subjective Well Being ◽  
Before And After ◽  
Onset Of Diabetes

Psychologic predictors of compliance in children with recent onset of diabetes mellitus

1987 ◽  
Vol 110 (5) ◽  
pp. 805-811 ◽  
Author(s):  
Alan M. Jacobson ◽  
Stuart T. Hauser ◽  
Joseph I. Wolfsdorf ◽  
John Houlihan ◽  
Janet E. Milley ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Recent Onset ◽  
Onset Of Diabetes

Patient with Diabetes Mellitus and Ocular Complications: A Brief review

2021 ◽  
pp. 141-145
Author(s):  
Naveen K L ◽  
Grinton Josvi Veigas ◽  
Ananya Bhattacharjee
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Action ◽  
Vision Loss ◽  
Ocular Complications ◽  
Autoimmune Destruction ◽  
Young Stage ◽  
Onset Of Diabetes ◽  
Heart Blood ◽  
Health Complications

Diabetes mellitus is metabolic disorder characterised by hyperglycaemia of human blood due to inadequate secretion and action of hormone insulin. Different classes of DM are Type-1, Type-2, neonatal, gestational and maturity onset of diabetes at young stage. The main pathologic cause for the DM is autoimmune destruction of β-cells and insulin deficiency due to resistance of insulin action caused by the abnormalities in metabolism of carbohydrates, protein and lipids which intern cause lack of insulin action on target tissues. Chronic stage of hyperglycaemia is associated with permanent damage, failure and dysfunction of various organs system, which includes heart, blood vessel, eyes, neurones and kidney. Long term DM may causes some health complications in patient such as nephropathy, neuropathy, retinopathy and other complications like peripheral vasculopathy and ischemia of heart. In current era ocular complications associated with DM are rapid and progressive, becoming world top most cause of morbidity. This article covers brief information regarding ocular complications and vision loss in patient with DM.

scholarly journals Evidence from Transgenic Mice That Interferon-β May Be Involved in the Onset of Diabetes Mellitus

1998 ◽  
Vol 273 (20) ◽  
pp. 12332-12340 ◽  
Author(s):  
Mireia Pelegrin ◽  
Jean Christophe Devedjian ◽  
Cristina Costa ◽  
Joana Visa ◽  
Gemma Solanes ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Transgenic Mice ◽  
Interferon Β ◽  
Onset Of Diabetes

Insulin secretion improvement during steroid therapy for autoimmune pancreatitis according to the onset of diabetes mellitus

2019 ◽  
Vol 55 (2) ◽  
pp. 198-204 ◽  
Author(s):  
Kensaku Noguchi ◽  
Yousuke Nakai ◽  
Suguru Mizuno ◽  
Hiroyuki Isayama ◽  
Kenji Hirano ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Steroid Therapy ◽  
Autoimmune Pancreatitis ◽  
Onset Of Diabetes
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