Maternal l-proline supplementation during gestation alters amino acid and polyamine metabolism in the first generation female offspring of C57BL/6J mice

Amino Acids ◽  
2019 ◽  
Vol 51 (5) ◽  
pp. 805-811 ◽  
Author(s):  
Ning Liu ◽  
Zhaolai Dai ◽  
Yunchang Zhang ◽  
Hai Jia ◽  
Jiangqing Chen ◽  
...  
Keyword(s):  
Amino Acid ◽  
First Generation ◽  
Female Offspring ◽  
Polyamine Metabolism ◽  
Generation Female

scholarly journals Amino acid and mineral composition of milk from local Ukrainian cows and their crossbreedings with Brown Swiss and Montbeliarde breeds

2018 ◽  
Vol 43 (3) ◽  
pp. 238 ◽  
Author(s):  
A. A. Borshch ◽  
A.V. Borshch ◽  
M.M. Lutsenko ◽  
S.V. Merzlov ◽  
L.T. Kosior ◽  
...  
Keyword(s):  
Amino Acid ◽  
Mineral Composition ◽  
Milk Protein ◽  
First Generation ◽  
Essential Amino Acids ◽  
Technological Properties ◽  
Crossbred Cows ◽  
Brown Swiss ◽  
Pure Breed ◽  
Dairy Breed

The aim of this study was to analyze the mineral composition of milk, the amino acid composition of milk protein, and the productivity per 305 days of lactation in crossbred cows compared to pure-breed local Ukrainian analogues. The research was conducted at cows of the Ukrainian Black-Spotted (UBS) dairy breed and crossbred cows of the first-generation obtained as a result of crossing with Brown Swiss breed and at cows of the Ukrainian Red-Spotted (URS) dairy breed and crossbred cows of the first-generation obtained by crossing of the URS dairy breed with Montbeliarde breed. In both farms there were two groups of pure-breed and crossbred cows-analogues. The mineral composition of milk and its technological properties in crossbred cows were higher compared to the pure-breed analogues. The fat content of milk crossbred cows exceeded by 0.08-0.16%, protein exceeded by 0.15-0.22%, and the main trace elements include Ca and P – by 2.66-8.83 and 2.12-7.81 mg/100 g of milk, respectively. Milk protein of crossbred cows was marked by a more balanced composition of essential amino acids (EAAs) and their ratio suitable for processing. The amount of EAAs in 100 g of milk protein of crossbred cows was 3.11-6.25% higher compared to local analogues. Crossbred cows dominated pure-breed analogues by the mineral composition of milk. The authors recommend the use of Montbeliarde or Brown Swiss breeds in commercial herds to improve the technological properties of milk.

scholarly journals Interrogating Conflicting Narratives of Writing in the Academy: A Call for Research

2017 ◽  
Vol 27 ◽  
pp. 13-18
Author(s):  
Katie Byrant
Keyword(s):  
First Generation ◽  
Academic Work ◽  
Writing Studies ◽  
University Student ◽  
Safe Haven ◽  
Feminist Politics ◽  
Generation Female ◽  
Subjective Identity

A safe haven in an often unsafe place: I would use this metaphor to describe the space writing studies and a university writing centre have offered me, as I’ve attempted to find my own place as a feminist in the academy. I feel these two things are my rocks. They are firm, solid places for me to reside amongst the challenges I’ve experienced as a writer. The reasons for my struggles with writing for academic purposes are difficult to pinpoint. Some would say they stem from my lack of literacy, hinting that laziness could be a culprit. Others might suggest they are connected to my subjective identity as a first-generation, female university student. Or others might take the discussion of subjective identity a bit further, arguing that my identity as a feminist, and my determination to bring my feminist politics into my academic work explain these challenges.

scholarly journals SMOX and SMS Responsible for Polyamine Metabolism Enhanced Adipogenesis

2021 ◽  
Author(s):  
Xia Yi ◽  
Ping Wu ◽  
Jianyun Liu ◽  
Ying Gong ◽  
Xiaoyuan Xu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Adipocyte Differentiation ◽  
Metabolic Diseases ◽  
Human Mesenchymal Stem Cells ◽  
Reduction Process ◽  
Polyamine Metabolism ◽  
Spermine Synthase ◽  
Oxidation Reduction

Abstract Adipose tissue regulating carbohydrate and lipid metabolism had been extensively focused. However, the regulation of amino acid metabolism during adipocyte differentiation remained detailed. Here we applied RNA-Seq technique to establish the transcriptional landscapes of amino acid metabolism during adipogenesis. We totally screened 17 differentially expressed genes (DEGs) for amino acid metabolism at 7, 14, 21, and 28 days during adipogenesis from human mesenchymal stem cells (hMSCs), especially with 13 up-regulated genes most prevalent in our adipogenic anecdote. Small molecule metabolic process was the most enriched biological process following by oxidation-reduction process. Interestingly, the enforced expression of SMOX (spermine oxidase) responsible for polyamine metabolism in arginine and proline metabolism pathway facilitated adipogenesis more than SMS (spermine synthase) using RNA interference (RNAi). The established potential regulatory network further suggested that adipocyte differentiation tightly related with the basal metabolism of amino acid metabolism with the partially confirmed SMS-SMOX-PPARG signaling pathway. It would highlight the effect of adipogenesis on amino acid metabolism in adipocyte biology and provide the potential treatment strategy for the study of fat metabolic diseases.

Parasitylenchus myiophagus n. sp. (Nematoda: Parasitylenchidae), a tylenchid nematode parasite of long-legged flies (Diptera: Dolichopodidae)

Zootaxa ◽  
2021 ◽  
Vol 5072 (1) ◽  
pp. 43-52
Author(s):  
GEORGE POINAR ◽  
JUSTIN B. RUNYON
Keyword(s):  
First Generation ◽  
Second Generation ◽  
Host Record ◽  
Body Cavity ◽  
Nematode Parasite ◽  
New Host ◽  
New Host Record ◽  
Nematode Parasitism ◽  
Males And Females ◽  
Generation Female

A tylenchid nematode parasite of a male long-legged fly, Tachytrechus sanus Osten Sacken (Diptera: Dolichopodidae) from Montana, USA is described as Parasitylenchus myiophagus n. sp. (Nematoda: Parasitylenchidae). The new species is characterized by the presence of an extremely long first generation female and numerous short and wide second generation males and females produced in “enclosed” clusters in the host’s body cavity. Both generation female nematodes are ovoviviparous, with short stylets lacking knobs and simple tails lacking spikes, palps or mucrons. The second generation males have paired, separate spicules, short stylets, and a bursa but no visible gubernaculum. The fly host shows evidence of demasculinization, which is attributed to nematode parasitism. The gonads of the second generation adults are infected with a microsporidium (Microsporidia), which is a new host record for tylenchid nematodes. A tylenchid-infected Baltic amber dolichopodid shows that associations between these two organisms extend back at least to the Eocene.  

Steinernema nguyeni n. sp. (Rhabditida: Steinernematidae), a new entomopathogenic nematode from South Africa

Nematology ◽  
2016 ◽  
Vol 18 (5) ◽  
pp. 571-590 ◽  
Author(s):  
Antoinette P. Malan ◽  
Rinus Knoetze ◽  
Louwrens R. Tiedt
Keyword(s):  
South Africa ◽  
New Species ◽  
Ribosomal Dna ◽  
First Generation ◽  
Entomopathogenic Nematode ◽  
Infective Juvenile ◽  
Lateral Field ◽  
Spicule Length ◽  
Molecular Features ◽  
Generation Female

Steinernema nguyenin. sp. was recovered by baiting from beneath anOlea africanatree in South Africa. The combination of morphological and molecular features suggests thatS. nguyenin. sp. is a member of thefeltiae-kraussei-oregonensegroup, clustering with members of this group in Clade III. The new species is morphologically characterised by the infective juvenile body length of 737 (673-796) μm and the number of ridges in the infective juvenile lateral field is 2, 8, 2. The male of the first generation can be recognised by the spicule length of 66 (58-75) μm and a gubernaculum length of 43 (30-55) μm. The first generation female can be recognised by the vulval lips only slightly protruding and the presence of low, double-flapped epiptygmata. Analysis of the ITS and D2-D3 regions of the ribosomal DNA confirms thatS. nguyenin. sp. differs from all other knownSteinernemaspecies.

scholarly journals Measuring immigration stress of first-generation female Korean immigrants in California: psychometric evaluation of Demand of Immigration Scale

2011 ◽  
Vol 16 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Ding Ding ◽  
C. Richard Hofstetter ◽  
Gregory J. Norman ◽  
Veronica L. Irvin ◽  
Douglas Chhay ◽  
...  
Keyword(s):  
First Generation ◽  
Psychometric Evaluation ◽  
Korean Immigrants ◽  
Generation Female ◽  
Immigration Stress

From Folklore to Molecular Pharmacophores: Cultivating STEM Students among Young, First-Generation Female Mexican-Americans

2011 ◽  
Vol 88 (1) ◽  
pp. 41-43 ◽  
Author(s):  
Jessica Gardea ◽  
Laura Rios ◽  
Rituraj Pal ◽  
Jorge L. Gardea-Torresdey ◽  
Mahesh Narayan
Keyword(s):  
Mexican Americans ◽  
First Generation ◽  
Stem Students ◽  
Generation Female

scholarly journals Risk of malignant neoplasms in the first generation offspring of female workers of Mayak Production Association

2021 ◽  
Vol 30 (4) ◽  
pp. 143-155
Author(s):  
S.F. Sosnina ◽  
◽  
P.V. Okatenko ◽  
M.E. Sokolnikov ◽  
◽  
...  
Keyword(s):  
Relative Risk ◽  
Cancer Incidence ◽  
First Generation ◽  
Female Offspring ◽  
Main Group ◽  
Production Association ◽  
Female Workers ◽  
Significant Difference ◽  
Mayak Production Association ◽  
Generation Offspring

The study of the role of parental preconception exposure in development of malignant neo-plasms (MN) in the offspring is a topical point in cancerogenic factors’ research. The objective of the work is assessment of cancer risk among the offspring of female workers of the country’s first atomic production facility – Mayak Production Association (PA) – exposed to long-term occupa-tional radiation exposure prior to conception. We have performed a retrospective epidemiological analysis in a cohort of offspring born in 1949-1990 that contained 2061 children from 1404 fe-male workers. Mothers of 1145 children (55.6%) had accumulated doses of preconception exter-nal gamma-exposure to the ovaries (main group); the remaining 916 children (44.4%) were re-garded as internal control (comparison group) as the offspring of female workers that were not exposed to preconception irradiation of genital organs. We have followed up the vital status and cancer incidence in the offspring up to 31.12.2018. We have performed an analysis of the struc-ture and cancer incidence rates. We had calculated the relative risk (RR) and the excess relative risk (ERR) to a dose unit of external gamma-exposure with a 95% confidence interval using the AMFIT module of the EPICURE software. A total of 92 MN cases were registered in 1949-2018 among the first generation offspring of female workers. A comparative analysis of cancer inci-dence showed no significant difference in the structure and incidence rate of MN in the groups. The only exception were the offspring of the females not exposed to preconception occupational irradiation of genital organs; in this group we had indicated a significant increase of brain MN in male offspring and of the MN of corpus uteri among female offspring. We had registered MN of digestive organs and MN of breast most often in the main group of the offspring. The range of maternal doses of preconception external gamma-exposure to the ovaries varied greatly: maxi-mum dose in male offspring reached 2954.82 mGy and 4075.61 in female offspring. Calculation of RR of MN in the offspring of the main group showed no significant difference from the com-parison group for all the MN, for solid cancers separately, and for other most frequent cancers. Assessment of ERR coefficients in relation to maternal accumulated absorbed dose of precon-ception external gamma radiation to the ovaries had revealed no statistically significant increase of cancer incidence among the offspring of female workers exposed to occupational irradiation of genital organs. We had obtained no reliable evidence in our investigation of the relation be-tween MN in the offspring of Mayak PA female workers and accumulated doses of preconception external gamma-exposure to the gonads. Further research is needed taking into account relative-ly young average age of the observed cohort of the offspring.

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