Prognostic role of Oct4, CD44 and c-Myc in radio–chemo-resistant oral cancer patients and their tumourigenic potential in immunodeficient mice

2015 ◽  
Vol 20 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Sharada Sawant ◽  
Ravindran Gokulan ◽  
Harsh Dongre ◽  
Milind Vaidya ◽  
Devendra Chaukar ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Prognostic Role ◽  
Immunodeficient Mice ◽  
Oral Cancer Patients

scholarly journals Droplet Digital PCR Analysis of Liquid Biopsy Samples Unveils the Diagnostic Role of hsa-miR-133a-3p and hsa-miR-375-3p in Oral Cancer

Biology ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 379
Author(s):  
Salvatore Crimi ◽  
Luca Falzone ◽  
Giuseppe Gattuso ◽  
Caterina Maria Grillo ◽  
Saverio Candido ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Liquid Biopsy ◽  
Digital Pcr ◽  
Droplet Digital Pcr ◽  
Pcr Analysis ◽  
Screening Programs ◽  
Diagnostic Potential ◽  
Oral Cancer Patients

Despite the availability of screening programs, oral cancer deaths are increasing due to the lack of diagnostic biomarkers leading to late diagnosis and a poor prognosis. Therefore, there is an urgent need to discover novel effective biomarkers for this tumor. On these bases, the aim of this study was to validate the diagnostic potential of microRNAs (miRNAs) through the analysis of liquid biopsy samples obtained from ten oral cancer patients and ten healthy controls. The expression of four selected miRNAs was evaluated by using droplet digital PCR (ddPCR) in a pilot cohort of ten oral cancer patients and ten healthy donors. Bioinformatics analyses were performed to assess the functional role of these miRNAs. The expression levels of the predicted down-regulated hsa-miR-133a-3p and hsa-miR-375-3p were significantly reduced in oral cancer patients compared to normal individuals while no significant results were obtained for the up-regulated hsa-miR-503-5p and hsa-miR-196a-5p. ROC analysis confirmed the high sensitivity and specificity of hsa-miR-375-3p and hsa-miR-133a-3p. Therefore, both miRNAs are significantly down-regulated in cancer patients and can be used as biomarkers for the early diagnosis of oral cancer. The analysis of circulating miRNAs in a larger series of patients is mandatory to confirm the results obtained in this pilot study.

Abstract 3700: Role of salivary miRNAs and their target genes in oral cancer patients as a potential diagnostic tool

2020 ◽  
Author(s):  
Muhammad Jawad Khan ◽  
Andleeb Zahra ◽  
Ghulam Rabia ◽  
Syeda Aba Ali ◽  
Shanza Sahar ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Diagnostic Tool ◽  
Target Genes ◽  
Oral Cancer Patients

scholarly journals Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients

2016 ◽  
Vol 21 (01) ◽  
pp. 21-27 ◽  
Author(s):  
Saurabh Bobdey ◽  
Balasubramaniam Ganesh ◽  
Prabhashankar Mishra ◽  
Aanchal Jain
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Neutrophil To Lymphocyte Ratio ◽  
Monocyte Count ◽  
Lymphocyte Ratio ◽  
Oral Cancer Patients

The Role of Socioeconomic Status and Literacy in the treatment delay in Oral Cancer patients Visiting Mayo Hospital

2021 ◽  
Vol 15 (8) ◽  
pp. 1785-1787
Author(s):  
Ahmad Liaquat ◽  
Rabia Naseer ◽  
Muhammad Rashid ◽  
Saqib Mehmood Khan ◽  
Ehsan Ul Haq ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Treatment Delay ◽  
Stage Iii ◽  
Care Hospital ◽  
Low Socioeconomic ◽  
Oral Cancer Patients ◽  
Late Stages

Background: One of the most important prognostic factors of oral cancer is the stage at the time of diagnosis. Unfortunately, most of the patients present in the late stages (stage III and IV). Aim: To assess the role of socioeconomic status and literacy in the treatment delay in patients of oral cancer. By identifying their role, we can educate the general public and healthcare doctors to detect and treat oral cancer. Method: This was a prospective study conducted in the Mayo hospital, a tertiary care hospital of Pakistan, from June 2018 to June 2020. Results: Out of 120 patients, 84 (70%) were males and 36 (30%) were females. The age range was 14 to 85 years. One hundred and eight patients (90%) presented with the late stages (stage III and IV). These late-stage presenter patients belonged to the low socioeconomic status (88.88%) and 83.33% of them were illiterate (<high school education). Only twelve patients (10%) presented with the early stage at the time of diagnosis. Conclusion: Low socioeconomic and lack of education have a significant association with the late presentation of oral cancer patients in the Pakistani population. Keywords: squamous cell carcinoma, treatment delay, socioeconomic status

Detection of oncometabolite nicotine imine in the nail of oral cancer patients and predicted as an inhibitor of DNMT1

2021 ◽  
Vol 16 ◽  
Author(s):  
Anwesha Deep Dutta ◽  
Ajay Kumar ◽  
Kiran Bharat Lokhande ◽  
Manmohan Mitruka ◽  
K. Venkateswara Swamy ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Dna Methyltransferase ◽  
Biological Fluids ◽  
Md Simulations ◽  
Dynamics Simulation ◽  
Dna Hypomethylation ◽  
Oral Cancer Patients

Background: Nicotine-metabolized product nicotine imine is suggested to play a role in metabolic changes in oral cancer. There is a significant gap in the detection of oncometabolite nicotine imine in biological fluids and nails of oral cancer patients. Oncometabolites are designated as metabolites those are usually elevated in cancer cells over normal cells. Interestingly, a direct or indirect link is missing that establishes a role of nicotine imine in pro-cancer cellular events including global DNA hypomethylation, a potential metabolic-epigenetic axis in oral cancer. Methods: A novel vertical tube gel electrophoresis (VTGE) system assisted purification and liquid chromatography-high resolution mass spectrometry (LC-HRMS) based identification of nicotine imine in the nails of oral cancer patients. Further, nicotine imine was evaluated for its molecular interactions with various methyltransferases including DNA methyltransferase 1 (DNMT1) by molecular docking and molecular dynamics (MD) simulations. Results: Data suggested the presence of nicotine imine in the nails of oral cancer patients. Molecular docking and MD simulations revealed a specific binding affinity by nicotine imine with DNMT1. Binding by nicotine imine is within the CXCC regulatory domain of DNMT1 including key residues as ARG690, PRO574, VAL658, PRO692 and ALA695. Similar binding residues are displayed by DNMT1 inhibitor 5'-Aza-2'-deoxycytidine. Conclusion : Nicotine imine is suggested as a predictive biomarker for oral cancer patients in nails and this finding is a first report. Molecular docking and dynamics simulation propose the role of nicotine imine as an inhibitor of DNMT1. This work supports the involvement of synergistic pro-tumor metabolic-epigenomic axis by nicotine imine that may contribute towards potential mutagenesis of normal squamous epithelium.

Risk factors for osteonecrosis of the jaw in oral cancer patients after surgery and eventual adjuvant treatment: The potential role of chemotherapy

2017 ◽  
Vol 123 (3) ◽  
pp. 406-411 ◽  
Author(s):  
Tzu-Yu Lai ◽  
Ti-Hao Wang ◽  
Chia-Jen Liu ◽  
Tze-Fan Chao ◽  
Tzeng-Ji Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Adjuvant Treatment ◽  
Potential Role ◽  
Osteonecrosis Of The Jaw ◽  
Oral Cancer Patients

scholarly journals The role of teledentistry in oral cancer patients during the COVID-19 pandemic: an integrative literature review

2021 ◽  
Author(s):  
Helbert Eustáquio Cardoso da Silva ◽  
Glaucia Nize Martins Santos ◽  
André Ferreira Leite ◽  
Carla Ruffeil Moreira Mesquita ◽  
Paulo Tadeu de Souza Figueiredo ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Literature Review ◽  
Cancer Patients ◽  
Oral Cancer Patients

The role of perineural invasion in treatment decisions for oral cancer patients: A review of the literature

2017 ◽  
Vol 45 (6) ◽  
pp. 821-825 ◽  
Author(s):  
Ioannis Chatzistefanou ◽  
Joshua Lubek ◽  
Konstantinos Markou ◽  
Robert A. Ord
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Perineural Invasion ◽  
Treatment Decisions ◽  
Review Of The Literature ◽  
Oral Cancer Patients
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