scholarly journals Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients

2016 ◽  
Vol 21 (01) ◽  
pp. 21-27 ◽  
Author(s):  
Saurabh Bobdey ◽  
Balasubramaniam Ganesh ◽  
Prabhashankar Mishra ◽  
Aanchal Jain
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Neutrophil To Lymphocyte Ratio ◽  
Monocyte Count ◽  
Lymphocyte Ratio ◽  
Oral Cancer Patients

scholarly journals Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Yun Yang ◽  
Rongxun Liu ◽  
Feng Ren ◽  
Rui Guo ◽  
Pengfei Zhang
Keyword(s):  
Oral Cancer ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Tumor Stage ◽  
Neutrophil To Lymphocyte Ratio ◽  
Advanced Tumor Stage ◽  
Lymphocyte Ratio ◽  
Advanced Tumor ◽  
Oral Cancer Patients ◽  
Clinicopathological Significance

Objectives: Many studies have examined the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in oral cancer; however, the results are contradictory. We, therefore, conducted a meta-analysis aiming to clarify the prognostic value of the NLR in oral cancer patients. Methods: A literature search was conducted in the PubMed, Web of Science, and Embase databases. Stata version 12.0 was used for statistical analysis. Results: A total of 14 studies with 3216 patients were finally included. The results indicated that a high NLR was significantly associated with worse DFS (n=10, HR = 1.73, 95% confidence interval [CI] = 1.44–2.07, P<0.001). Similar results were observed for overall survival (OS) (n=9, HR = 1.61, 95% CI = 1.39–1.86, P<0.001). Moreover, a high NLR was also correlated with lymph node metastasis (n=7, odds ratio [OR] = 1.62, 95% CI = 1.32–1.98, P<0.001), advanced tumor stage (n=7, OR = 2.63, 95% CI = 2.12–3.25, P<0.001), T stage (n=6, OR = 3.22, 95% CI = 2.59–4.01, P<0.001), tumor differentiation (n=5, OR = 1.48, 95% CI = 1.03–2.11, P=0.033), and perineural invasion (n=4, OR = 1.83, 95% CI = 1.4–2.39, P<0.001). However, an elevated NLR was not correlated with gender. Conclusion: This meta-analysis showed that the NLR might be a potential independent prognostic factor in patients with oral cancer.

scholarly journals Systemic Inflammatory Response Based on Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker in Bladder Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Hyung Suk Kim ◽  
Ja Hyeon Ku
Keyword(s):  
Inflammatory Response ◽  
Cancer Patients ◽  
Systemic Inflammatory Response ◽  
Neutrophil To Lymphocyte Ratio ◽  
Oncologic Outcomes ◽  
Survival Outcomes ◽  
Lymphocyte Ratio ◽  
The Past ◽  
Differential White Blood Cell

A growing body of evidence suggests that systemic inflammatory response (SIR) in the tumor microenvironment is closely related to poor oncologic outcomes in cancer patients. Over the past decade, several SIR-related hematological factors have been extensively investigated in an effort to risk-stratify cancer patients to improve treatment selection and to predict posttreatment survival outcomes in various types of cancers. In particular, one readily available marker of SIR is neutrophil-to-lymphocyte ratio (NLR), which can easily be measured on the basis of absolute neutrophils and absolute lymphocytes in a differential white blood cell count performed in the clinical setting. Many investigators have vigorously assessed NLR as a potential prognostic biomarker predicting pathological and survival outcomes in patients with urothelial carcinoma (UC) of the bladder. In this paper, we aim to present the prognostic role of NLR in patients with UC of the bladder through a thorough review of the literature.

Prognostic role of Oct4, CD44 and c-Myc in radio–chemo-resistant oral cancer patients and their tumourigenic potential in immunodeficient mice

2015 ◽  
Vol 20 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Sharada Sawant ◽  
Ravindran Gokulan ◽  
Harsh Dongre ◽  
Milind Vaidya ◽  
Devendra Chaukar ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Prognostic Role ◽  
Immunodeficient Mice ◽  
Oral Cancer Patients

scholarly journals Droplet Digital PCR Analysis of Liquid Biopsy Samples Unveils the Diagnostic Role of hsa-miR-133a-3p and hsa-miR-375-3p in Oral Cancer

Biology ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 379
Author(s):  
Salvatore Crimi ◽  
Luca Falzone ◽  
Giuseppe Gattuso ◽  
Caterina Maria Grillo ◽  
Saverio Candido ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Liquid Biopsy ◽  
Digital Pcr ◽  
Droplet Digital Pcr ◽  
Pcr Analysis ◽  
Screening Programs ◽  
Diagnostic Potential ◽  
Oral Cancer Patients

Despite the availability of screening programs, oral cancer deaths are increasing due to the lack of diagnostic biomarkers leading to late diagnosis and a poor prognosis. Therefore, there is an urgent need to discover novel effective biomarkers for this tumor. On these bases, the aim of this study was to validate the diagnostic potential of microRNAs (miRNAs) through the analysis of liquid biopsy samples obtained from ten oral cancer patients and ten healthy controls. The expression of four selected miRNAs was evaluated by using droplet digital PCR (ddPCR) in a pilot cohort of ten oral cancer patients and ten healthy donors. Bioinformatics analyses were performed to assess the functional role of these miRNAs. The expression levels of the predicted down-regulated hsa-miR-133a-3p and hsa-miR-375-3p were significantly reduced in oral cancer patients compared to normal individuals while no significant results were obtained for the up-regulated hsa-miR-503-5p and hsa-miR-196a-5p. ROC analysis confirmed the high sensitivity and specificity of hsa-miR-375-3p and hsa-miR-133a-3p. Therefore, both miRNAs are significantly down-regulated in cancer patients and can be used as biomarkers for the early diagnosis of oral cancer. The analysis of circulating miRNAs in a larger series of patients is mandatory to confirm the results obtained in this pilot study.

scholarly journals Prognostic role of high neutrophil-to-lymphocyte ratio in breast cancer patients receiving neoadjuvant chemotherapy

Medicine ◽  
2019 ◽  
Vol 98 (1) ◽  
pp. e13842 ◽  
Author(s):  
Ling Bo Xue ◽  
Yong Hong Liu ◽  
Bo Zhang ◽  
Yan Fang Yang ◽  
Dong Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Neutrophil To Lymphocyte Ratio ◽  
Breast Cancer Patients ◽  
Prognostic Role ◽  
Lymphocyte Ratio

Prognostic role of neutrophil-to-lymphocyte ratio in castration-resistant prostate cancer patients treated with docetaxel.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e16050-e16050
Author(s):  
Atike Pinar ◽  
Ahmet Ozveren ◽  
Zeki Gokhan Surmeli ◽  
Ulus Ali Sanli ◽  
Ruchan Uslu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Neutrophil To Lymphocyte Ratio ◽  
Castration Resistant Prostate Cancer ◽  
Prognostic Role ◽  
Lymphocyte Ratio ◽  
Castration Resistant

Abstract 3700: Role of salivary miRNAs and their target genes in oral cancer patients as a potential diagnostic tool

2020 ◽  
Author(s):  
Muhammad Jawad Khan ◽  
Andleeb Zahra ◽  
Ghulam Rabia ◽  
Syeda Aba Ali ◽  
Shanza Sahar ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Diagnostic Tool ◽  
Target Genes ◽  
Oral Cancer Patients

The Role of Socioeconomic Status and Literacy in the treatment delay in Oral Cancer patients Visiting Mayo Hospital

2021 ◽  
Vol 15 (8) ◽  
pp. 1785-1787
Author(s):  
Ahmad Liaquat ◽  
Rabia Naseer ◽  
Muhammad Rashid ◽  
Saqib Mehmood Khan ◽  
Ehsan Ul Haq ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Treatment Delay ◽  
Stage Iii ◽  
Care Hospital ◽  
Low Socioeconomic ◽  
Oral Cancer Patients ◽  
Late Stages

Background: One of the most important prognostic factors of oral cancer is the stage at the time of diagnosis. Unfortunately, most of the patients present in the late stages (stage III and IV). Aim: To assess the role of socioeconomic status and literacy in the treatment delay in patients of oral cancer. By identifying their role, we can educate the general public and healthcare doctors to detect and treat oral cancer. Method: This was a prospective study conducted in the Mayo hospital, a tertiary care hospital of Pakistan, from June 2018 to June 2020. Results: Out of 120 patients, 84 (70%) were males and 36 (30%) were females. The age range was 14 to 85 years. One hundred and eight patients (90%) presented with the late stages (stage III and IV). These late-stage presenter patients belonged to the low socioeconomic status (88.88%) and 83.33% of them were illiterate (<high school education). Only twelve patients (10%) presented with the early stage at the time of diagnosis. Conclusion: Low socioeconomic and lack of education have a significant association with the late presentation of oral cancer patients in the Pakistani population. Keywords: squamous cell carcinoma, treatment delay, socioeconomic status

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