scholarly journals Usefulness of hemoglobin examination in gingival crevicular fluid during supportive periodontal therapy to diagnose the pre-symptomatic state in periodontal disease

2020 ◽  
Author(s):  
Hiroshi Ito ◽  
Yukihiro Numabe ◽  
Shuichi Hashimoto ◽  
Sunao Uehara ◽  
Ya-Hsin Wu ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Supportive Periodontal Therapy ◽  
Crevicular Fluid

scholarly journals Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population

2017 ◽  
Vol 18 (11) ◽  
pp. 1085-1089 ◽  
Author(s):  
Monica J Mahajani ◽  
Varsha A Jadhao ◽  
Pooja S Wankhade ◽  
Emmanuel Samson ◽  
Vishwas D Acharya ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Interleukin 18 ◽  
Periodontal Health ◽  
Group I ◽  
Nonsurgical Periodontal Therapy ◽  
Health And Disease ◽  
Group Ii ◽  
Crevicular Fluid

ABSTRACT Aim The incidence and progression of the periodontal disease depend on periodontal microflora and the multifaceted response of the host, and these interactions are mediated by cytokines and chemokines. Interleukin-18 (IL-18) is a proinflammatory cytokine of the IL-1 superfamily. The aim of the present study was the assessment of the periodontal therapy in IL-18 level in periodontal disease and health. Materials and methods Based on clinical attachment loss (CAL), probing pocket depth (PPD), gingival index (GI), and plaque index (PI) patients were divided into three groups: Group I with healthy patients, group II with chronic periodontitis, and group III with posttreatment patients having periodontitis. Results Mean PI, PPD, CAL, and gingival crevicular fluid (GCF) volume were significantly higher in groups II and III compared with group I. However, there were no significant differences between GI in groups I, II, and III. The total amount of IL-18 in GCF was significantly higher in group II when compared with groups I and III (p < 0.05). Conclusion The present study confirmed that the IL-18 level in GCF was lower in healthy patients, higher in periodontally involved patients, and reduced at baseline, 3 and 6 weeks after nonsurgical periodontal therapy. Clinical significance The IL-18 might be hypothetically beneficial in distinguishing health from disease and monitoring periodontal disease activity. How to cite this article Mahajani MJ, Jadhao VA, Wankhade PS, Samson E, Acharya VD, Tekale PD. Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population. J Contemp Dent Pract 2017;18(11):1085-1089.

scholarly journals Phospholipase A2Activity in Gingival Crevicular Fluid from Patients with Periodontal Disease: A possible Marker of Disease Activity

1994 ◽  
Vol 3 (1) ◽  
pp. 17-21 ◽  
Author(s):  
H. Ishida ◽  
H. Shinohara ◽  
T. Nagata ◽  
S. Nishikawa ◽  
Y. Wakano
Keyword(s):  
Enzyme Activity ◽  
Periodontal Disease ◽  
Disease Activity ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Phospholipase A ◽  
Bleeding On Probing ◽  
Before And After ◽  
Crevicular Fluid

The activity of phospholipase A2in human gingival crevicular fluid (GCF) associated with periodontal disease was demonstrated. Based upon the presence or absence of bleeding on probing (BOP), which is a marker for the disease activity, there were higher levels of the enzyme activity in BOP positive, than in negative sites. When the BOP positive sites became negative after periodontal therapy, the enzyme activity decreased dramatically to almost undetectable levels. There were no significant differences between the activity before and after treatment when the BOP positive sites remained unchanged. These results suggest that the activity in GCF reflects periodontal disease conditions and that it can be used as a marker for disease activity.

Salivary Diagnosis - Clinical Uses in Assessing Oral Inflammation

2017 ◽  
Vol 68 (6) ◽  
pp. 1201-1204 ◽  
Author(s):  
Iulia Ioana Stanescu ◽  
Alexandra Totan ◽  
Florentina Rus ◽  
Daniela Miricescu ◽  
Brandusa Mocanu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Oxidative Stress Marker ◽  
Clinical Settings ◽  
Tissue Destruction ◽  
Whole Saliva ◽  
Oral Inflammation ◽  
Positive Correlations ◽  
Crevicular Fluid

The past decades demonstrated that saliva and its components represent a remarkable diagnosis fluid with valuable clinical uses for both oral and systemic diseases. At the same time it is well established that oxidative stress is involved in a wide number of pathologies, including periodontitis. The specific aim of the present study which included 50 subjects is to determine if saliva can be used in clinical settings to correlate oxidative stress and tissue destruction markers with the severity of periodontal disease. An important oxidative stress marker - 8-hydroxydesoxyguanosine (8-OHdG) and a collagen degradation marker - beta-crosslaps (b-CTX) were quantified in both saliva and gingival crevicular fluid (GCF) using ELISA kits and were found to be significantly increased in the chronic periodontitis group when compared to respective controls (p[0.05). At the same time positive correlations were observed between whole saliva and gingival crevicular fluid (p[0.05). Significant correlations were also determined between GCF and salivary markers and clinical parameters of periodontal disease. Present results demonstrate that saliva and its components can successfully be used in clinical settings and represents a reliable tool for assessing periodontal disease severity.

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