Pathological Evaluation of Renal Tumors in Children: International Society of Pediatric Oncology Approach

1998 ◽  
Vol 1 (3) ◽  
pp. 243-248 ◽  
Author(s):  
Liliane A. Boccon-Gibod
Keyword(s):  
International Society ◽  
Pediatric Oncology ◽  
Wilms Tumor ◽  
Risk Group ◽  
Renal Tumors ◽  
Pathological Evaluation ◽  
Methods Of Treatment ◽  
New Criteria

In the majority of European countries, children with renal tumors now enter the SIOP-93-01 Trial and Study. The objective of this Study is to refine methods of treatment especialy in stage I patients. The role of institutional pathologists is important in this trial. There are new criteria for stages I and II, a new SIOP Working Classification of Renal Tumors of Childhood, and morphologic and prognostic similarities of pretreated and non-pretreated anaplastic cases. Specific problems encountered in assessing tumors treated with preoperative chemotherapy, administered to the majority of children over 6 months of age entering the SIOP Study, are discussed. The identification of a new low-risk group, the completely necrotic Wilms tumor, is outlined.

Results of children with renal tumors treated in the Austrian–Hungarian Wilms Tumor Study 1989 and the International Society of Pediatric Oncology (SIOP) 93-01/GPOH trial in Austria

2012 ◽  
Vol 5 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Claudia Zimmermann ◽  
Ulrike Pötschger ◽  
Gabriele Amann ◽  
Ernst Horcher ◽  
Karin Dieckmann ◽  
...  
Keyword(s):  
International Society ◽  
Pediatric Oncology ◽  
Wilms Tumor ◽  
Renal Tumors ◽  
Tumor Study

Using metaphors to get rid of a speech defect by Roman Jacobsen: توظيف الاستعارة في التخلص من العيب النطقي عند رومان جاكوبسن

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Huda Salah Rashid, Hatem Kareem Huseen
Keyword(s):  
Speech Defect ◽  
Linguistic Differences ◽  
Medical Office ◽  
Roman Jakobson ◽  
Definition Of ◽  
Methods Of Treatment

Praise be to Allah the Lord of the Worlds, prayer and peace be upon Ashraf senders and his family and his family companions either after: Vtad studies linguistics and one of the science of language that has developed a fast in a period of short, entered most of the fields of science and life different, and addressed various phenomena of language and non - language, has had to Ross's role significantly in the development and continuation of this field of scientific their researches and symposia and institutions of different, and these scientists Roman Jakobson, who has the role of a great in the development and discovery of theories and issues of linguistic differences, as well as for diseases of language, and the issues of technical and other, and the issues that dealt with Roman Jakobson with regard to diseases of words is aphasia verbal and treatment employing metaphor to get rid of these defects articulatory, and based also on the development of scientific The medical office in America used it to serve and treat verbal aphasia, as well as its classification of verbal confinement. The stated research entitled (employment of metaphor in the disposal of the defect Alntqa when Roman Jakobson), was a plan research dealt with the definition of abbreviated Proman Jacobson, then the definition of imprisonment verbal and types, definition Borrowing and types when Roman Jakobson, followed by methods of treatment for by metaphor, and a the conclusion that summarizes the most important what reached the search of results

Histopathological classification of childhood rhabdomyosarcoma: A report from the international society of pediatric oncology pathology panel

1989 ◽  
Vol 17 (5-6) ◽  
pp. 391-400 ◽  
Author(s):  
J. M. Caillaud ◽  
R. Gérard-Marchant ◽  
H. B. Marsden ◽  
A. J. M. Van Unnik ◽  
C. Rodary ◽  
...  
Keyword(s):  
International Society ◽  
Pediatric Oncology ◽  
Histopathological Classification ◽  
Childhood Rhabdomyosarcoma

Results of the Sixth International Society of Pediatric Oncology Wilms' Tumor Trial and Study: a risk-adapted therapeutic approach in Wilms' tumor.

1993 ◽  
Vol 11 (6) ◽  
pp. 1014-1023 ◽  
Author(s):  
M F Tournade ◽  
C Com-Nougué ◽  
P A Voûte ◽  
J Lemerle ◽  
J de Kraker ◽  
...  
Keyword(s):  
International Society ◽  
Pediatric Oncology ◽  
Wilms Tumor ◽  
Group Versus ◽  
Disease Free Survival ◽  
Stage I ◽  
Stage Ii ◽  
High Rate ◽  
Stage Iii ◽  
Sixth International

PURPOSE The Sixth International Society of Pediatric Oncology study (SIOP6) concerned Wilms' tumor with favorable histology, preoperatively treated to obtain a high rate of stage I patients, and sought to reduce treatment for patients with stage I and stage II negative nodes (IIN0) tumors and to find better therapy to prevent relapses in stage II positive nodes (IIN1) and stage III patients. PATIENTS AND METHODS Eligible patients (N = 509) had received four weekly doses of vincristine (VCR) and two courses of dactinomycin (AMD) preoperatively and were assigned after surgery, according to stage and lymph node involvement, to three different prognostic groups, which were to be randomized. Stage I patients (n = 303) received VCR and AMD either for 17 weeks (S) or 38 weeks (L). Stage IIN0 patients (n = 123) received either 20 Gy irradiation (R+) or no irradiation (R-) and received VCR and AMD for 38 weeks. Stage IIN1 and III patients (n = 83) received intensified VCR and AMD (INTVCR) versus VCR, AMD, and Adriamycin (ADRIA; Doxorubicin Farmitalia Carbo Erba, Rueil, Malmaison, France; doxorubicin). Assessment criteria were 2-year disease-free survival (DFS) and 5-year survival (SURV) percentages. A stopping rule was added that took into account abdominal recurrences for the stage IIN0 trial. RESULT A 52% rate of stage I tumors was obtained, with a low rate of ruptures (7%). The 2-year DFS and 5-year SURV rates according to the different therapeutic groups were stage I, 92% versus 88% (equivalent) and 95% versus 92% for S and L, respectively; stage IIN0, 72% versus 78% (stage equivalent) and 88% versus 85% for R+ and R-, respectively; and stage IIN1 and stage III, 49% versus 74% (P < .029) and 77% versus 80% for INTVCR and ADRIA, respectively, which results in an 82% DFS and 89% SURV rate for the entire trial population. However, six abdominal metastases observed during the first year of follow-up (FU) in the R- group versus none in the R+ group resulted in discontinuation of the stage IIN0 trial. CONCLUSION Risk-adapted therapy to limit risk of sequelae is possible. More intensive chemotherapy is necessary to prevent abdominal recurrences in nonirradiated stage IIN0 patients treated preoperatively. A three-drug protocol is necessary in stage IIN1 and stage III patients.

Revised International Society of Paediatric Oncology (SIOP) working classification of renal tumors of childhood

2002 ◽  
Vol 38 (2) ◽  
pp. 79-82 ◽  
Author(s):  
Gordan M. Vujani? ◽  
Bengt Sandstedt ◽  
Dieter Harms ◽  
Anna Kelsey ◽  
Ivo Leuschner ◽  
...  
Keyword(s):  
International Society ◽  
Paediatric Oncology ◽  
Renal Tumors

The role of biopsy in the diagnosis of renal tumors of childhood: Results of the UKCCSG Wilms tumor study 3

2002 ◽  
Vol 40 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Gordan M. Vujani? ◽  
Anna Kelsey ◽  
Chris Mitchell ◽  
Rosemary S. Shannon ◽  
Peter Gornall
Keyword(s):  
Wilms Tumor ◽  
Renal Tumors ◽  
Tumor Study

scholarly journals Characteristics and outcome of children with renal tumors in the Netherlands: The first five-year’s experience of national centralization

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0261729
Author(s):  
Prakriti Roy ◽  
Sophie E. van Peer ◽  
Martin M. de Witte ◽  
Godelieve A. M. Tytgat ◽  
Henrike E. Karim-Kos ◽  
...  
Keyword(s):  
The Netherlands ◽  
Pediatric Oncology ◽  
Renal Tumor ◽  
Wilms Tumor ◽  
Survival Rates ◽  
Renal Tumors ◽  
Childhood Malignancies ◽  
Netherlands Cancer Registry ◽  
Central Pathology ◽  
Centralized Care

Around 6% of all childhood malignancies represent renal tumors, of which a majority includes Wilms tumor (WT). Although survival rates have improved over the last decades, specific patients are still at risk for adverse outcome. In the Netherlands, since 2015, pediatric oncology care for renal tumors has been centralized in the Princess Máxima Center for Pediatric Oncology. Here, we describe experiences of the first 5 years of centralized care and explore whether this influences the epidemiological landscape by comparing data with the Netherlands Cancer Registry (NCR). We identified all patients <19 years with a renal mass diagnosed between 01-01-2015 and 31-12-2019 in the Princess Máxima Center. Epidemiology, characteristics and management were analyzed. We identified 164 patients (including 1 patient who refused consent for registration), in our center with a suspicion of a renal tumor. The remaining 163 cases included WT (n = 118)/cystic partially differentiated nephroblastoma (n = 2)/nephrogenic rests only (n = 6) and non-WT (n = 37). In this period, the NCR included 138 children, 1 17-year-old patient was not referred to the Princess Máxima Center. Central radiology review (before starting treatment) was performed in 121/163 patients, and central pathology review in 148/152 patients that underwent surgery. Treatment stratification, according to SIOP/EpSSG protocols was pursued based on multidisciplinary consensus. Preoperative chemotherapy was administered in 133 patients, whereas 19 patients underwent upfront surgery. Surgery was performed in 152 patients, and from 133 biomaterial was stored. Centralization of care for children with renal tumors led to referral of all but 1 new renal tumor cases in the Netherlands, and leads to referral of very rare subtypes not registered in the NCR, that benefit from high quality diagnostics and multidisciplinary decision making. National centralization of care led to enhanced development of molecular diagnostics and other innovation-based treatments for the future.

scholarly journals Current role of imaging in the management of children with Wilms tumor according to the new umbrella protocol

2020 ◽  
pp. 51-63
Author(s):  
Varchetta Giovanni ◽  
Tanzillo Paolina ◽  
Mei Sara
Keyword(s):  
Wilms Tumor ◽  
Abdominal Mass ◽  
Epidemiological Data ◽  
Renal Tumors ◽  
Postoperative Treatment ◽  
Malignant Rhabdoid Tumor ◽  
Presumptive Diagnosis ◽  
Medical Checkup ◽  
Abdominal Masses

Wilms tumor is the most common primary renal tumor in childhood. Children with Wilms tumor typically present with an asymptomatic abdominal mass, usually detected on a routine medical checkup or discovered coincidentally by parents. The initial differential diagnosis is with extrarenal abdominal masses; once a tumor of renal origin is established, distinguishing between Wilms tumor and other primary renal neoplasms such as congenital mesoblastic nephroma, clear cell sarcoma, malignant rhabdoid tumor and renal cell carcinoma may not be easy. However, in many cases imaging findings in conjunction with the patient's clinical and epidemiological data, allow the diagnosis of Wilms tumor. Wilms tumor care offers one of the most striking examples of success of pediatric oncology. Over the last decades the European SIOP studies have been the key to developing standardized diagnostic procedures, improved risk stratification, and adjusted treatment recommendations for children with Wilms tumor and this has resulted rate of overall survival is currently greater than 90%. As in previous SIOP trials and studies, the new protocol for the diagnosis and treatment of childhood renal tumors, the UMBRELLA SIOP–RTSG 2016, mandates preoperative chemotherapy without preceding mandatory histological assessment. Therefore, imaging studies are essential to obtain a presumptive diagnosis of WT, to provide disease staging information and to measure the tumor volume after neoadjuvant chemotherapy for the purposes of postoperative treatment stratification. This review describes role of imaging in the management of children with Wilms tumor, according to the current recommendations of the UMBRELLA protocol.

Long-term Follow-up of Infantile Wilms Tumor Treated According to International Society of Pediatric Oncology Protocol: Seven Years' Follow-up

Urology ◽  
2011 ◽  
Vol 77 (2) ◽  
pp. 446-451 ◽  
Author(s):  
Heba Abdel Razik Sayed ◽  
Amany Mohamed Ali ◽  
Hesham Mahmoud Hamza ◽  
Medhat Ahmed Abdalla
Keyword(s):  
International Society ◽  
Pediatric Oncology ◽  
Wilms Tumor ◽  
Long Term Follow Up
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