scholarly journals Review and reflections about pulsatile ventricular assist devices from history to future: concerning safety and low haemolysis—still needed

2020 ◽  
Vol 23 (4) ◽  
pp. 303-314
Author(s):  
Inge Köhne
Keyword(s):  
Continuous Flow ◽  
Pediatric Patients ◽  
Low Cost ◽  
Ventricular Assist Devices ◽  
Assist Device ◽  
Ventricular Assist ◽  
Pump Failure ◽  
Blood Pumps ◽  
Rotary Pumps

AbstractSince the first use of a ventricular assist device in 1963 many extracorporeal and implantable pulsatile blood pumps have been developed. After the invention of continuous flow blood pumps the implantable pulsatile pumps are not available anymore. The new rotary pumps spend a better quality of life because many of the patients can go home. Nevertheless, the extracorporeal pulsatile pumps have some advantages. They are low-cost systems, produce less haemolysis and heart-recovery can be tested easily. Pump failure is easy to realize because the pumps can be observed visually. Pump exchange can be done easily without any chirurgic surgery. As volume displacement pumps they can produce high blood pressure, so they are the only ones suitable for pediatric patients. Therefore, they are indispensable for clinical use today and in the future. In this work, nearly all pulsatile blood pumps used in clinical life are described.

scholarly journals Haemolysis induced by mechanical circulatory support devices: unsolved problems

Perfusion ◽  
2020 ◽  
Vol 35 (6) ◽  
pp. 474-483
Author(s):  
Inge Köhne
Keyword(s):  
Shear Stress ◽  
Continuous Flow ◽  
Mechanical Circulatory Support ◽  
Ventricular Assist Devices ◽  
Circulatory Support ◽  
Ventricular Assist ◽  
Theoretical Approaches ◽  
Blood Pumps ◽  
Mechanical Circulatory Support Devices ◽  
Support Devices

Since the use of continuous flow blood pumps as ventricular assist devices is standard, the problems with haemolysis have increased. It is mainly induced by shear stress affecting the erythrocyte membrane. There are many investigations about haemolysis in laminar and turbulent blood flow. The results defined as threshold levels for the damage of erythrocytes depend on the exposure time of the shear stress, but they are very different, depending on the used experimental methods or the calculation strategy. Here, the results are resumed and shown in curves. Different models for the calculation of the strengths of erythrocytes are discussed. There are few results reported about tests of haemolysis in blood pumps, but some theoretical approaches for the design of continuous flow blood pumps according to low haemolysis have been investigated within the last years.

scholarly journals Asynchronous Pumping of a Pulsatile Ventricular Assist Device in a Pediatric Anastomosis Model

2017 ◽  
Vol 8 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Bryan C. Good ◽  
William J. Weiss ◽  
Steven Deutsch ◽  
Keefe B. Manning
Keyword(s):  
Phase Shift ◽  
Continuous Flow ◽  
Power Loss ◽  
Graft Failure ◽  
Congenital Heart ◽  
Ventricular Assist Devices ◽  
Oscillatory Shear Index ◽  
Assist Device ◽  
Ventricular Assist ◽  
Aortic Anastomosis

Background: Both pulsatile and continuous flow ventricular assist devices are being developed for pediatric congenital heart defect patients. Pulsatile devices are often operated asynchronously with the heart in either an “automatic” or a fixed beat rate mode. However, most studies have only investigated synchronized ejection. Methods: A previously validated viscoelastic blood solver is used to investigate the parameters of pulsatility, power loss, and graft failure in a pediatric aortic anastomosis model. Results: Pulsatility was highest with synchronized flow and lowest at a 90° phase shift. Power loss decreased at 90° and 180° phase shifts but increased at a 270° phase shift. Similar regions of potential intimal hyperplasia and graft failure were seen in all cases but with phase-shifted ejection leading to higher wall shear stress on the anastomotic floor and oscillatory shear index on the anastomotic toe. Conclusion: The ranges of pulsatility and hemodynamics that can result clinically using asynchronous pulsatile devices were investigated in a pediatric anastomosis model. These results, along with the different postoperative benefits of pump modulation, can be used to design an optimal weaning protocol.

Trends in Body Mass Index and Association With Outcomes in Pediatric Patients on Continuous Flow Ventricular Assist Device Support

ASAIO Journal ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kriti Puri ◽  
Iki Adachi ◽  
Claire E. Bocchini ◽  
Joseph A. Spinner ◽  
Susan W. Denfield ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Ventricular Assist Device ◽  
Continuous Flow ◽  
Pediatric Patients ◽  
Assist Device ◽  
Ventricular Assist

HeartMate II Continuous Flow Left Ventricular Assist Device Improves Functional Capacity and Quality of Life

2007 ◽  
Vol 13 (6) ◽  
pp. S111 ◽  
Author(s):  
David B. Dyke ◽  
Francis D. Pagani ◽  
Stuart D. Russell ◽  
Andrew Boyle ◽  
David J. Farrar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Capacity ◽  
Left Ventricular Assist Device ◽  
Continuous Flow ◽  
Left Ventricular ◽  
Assist Device ◽  
Heartmate Ii ◽  
Ventricular Assist ◽  
Left Ventricular Assist
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