Anti-inflammatory, counteractive, and preventive effects of orally administrated oat extracts on dextran sulfate sodium-induced colitis in mice

2015 ◽  
Vol 24 (2) ◽  
pp. 619-628 ◽  
Author(s):  
Md. Abul Hasnat ◽  
Mehnaz Pervin ◽  
Sa Ra Park ◽  
Yong Chang Jang ◽  
Ji Hong Lim ◽  
...  
Keyword(s):  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Anti Inflammatory ◽  
Preventive Effects

scholarly journals Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2630
Author(s):  
Jiah Yeom ◽  
Seongho Ma ◽  
Jeong-Keun Kim ◽  
Young-Hee Lim
Keyword(s):  
Inflammatory Cytokine ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Intestinal Inflammation ◽  
Mucus Layer ◽  
Beneficial Effects ◽  
Intestinal Mucus ◽  
Anti Inflammatory ◽  
Apoptotic Effects ◽  
Intestinal Mucus Layer

Colitis causes destruction of the intestinal mucus layer and increases intestinal inflammation. The use of antioxidants and anti-inflammatory agents derived from natural sources has been recently highlighted as a new approach for the treatment of colitis. Oxyresveratrol (OXY) is an antioxidant known to have various beneficial effects on human health, such as anti-inflammatory, antibacterial activity, and antiviral activity. The aim of this study was to investigate the therapeutic effect of OXY in rats with dextran sulfate sodium (DSS)-induced acute colitis. OXY ameliorated DSS-induced colitis and repaired damaged intestinal mucosa. OXY downregulated the expression of pro-inflammatory cytokine genes (TNF-α, IL-6, and IL-1β) and chemokine gene MCP-1, while promoting the production of anti-inflammatory cytokine IL-10. OXY treatment also suppressed inflammation via inhibiting cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in the colon, as well as the activity of myeloperoxidase (MPO). OXY exhibited anti-apoptotic effects, shifting the Bax/Bcl-2 balance. In conclusion, OXY might improve DSS-induced colitis by restoring the intestinal mucus layer and reducing inflammation within the intestine.

scholarly journals Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1895
Author(s):  
Azra Memon ◽  
Bae Yong Kim ◽  
Se-eun Kim ◽  
Yuliya Pyao ◽  
Yeong-Geun Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Animal Model ◽  
Gastric Ulcer ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Inos Expression ◽  
Gastrointestinal Inflammation ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
Inflammatory Effect

Background: Phytoncide is known to have antimicrobial and anti-inflammatory properties. Purpose: This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. Methods: We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Result: In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (p < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (p < 0.05). Conclusions: Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.

Antioxidant and anti-inflammatory effect of plumieride in dextran sulfate sodium-induced colitis in mice

2018 ◽  
Vol 99 ◽  
pp. 697-703 ◽  
Author(s):  
Thaise Boeing ◽  
Priscila de Souza ◽  
Tiago José Bonomini ◽  
Luísa Nathália Bolda Mariano ◽  
Lincon Bordignon Somensi ◽  
...  
Keyword(s):  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Evaluation of the Anti-Inflammatory Effect of Baicalein on Dextran Sulfate Sodium-Induced Colitis in Mice

Planta Medica ◽  
2002 ◽  
Vol 68 (3) ◽  
pp. 268-271 ◽  
Author(s):  
Tie Hong ◽  
Guang-Bi Jin ◽  
Shigefumi Cho ◽  
Jong-Chol Cyong
Keyword(s):  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Carbon Monoxide Liberated from Carbon Monoxide-Releasing Molecule Exerts an Anti-inflammatory Effect on Dextran Sulfate Sodium-Induced Colitis in Mice

2010 ◽  
Vol 56 (6) ◽  
pp. 1663-1671 ◽  
Author(s):  
Tomohisa Takagi ◽  
Yuji Naito ◽  
Kazuhiko Uchiyama ◽  
Takahiro Suzuki ◽  
Ikuhiro Hirata ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Effects of anti-inflammatory therapy on bursting pressure of colonic anastomosis in murine dextran sulfate sodium induced colitis

2015 ◽  
Vol 50 (8) ◽  
pp. 991-1001 ◽  
Author(s):  
Pär Myrelid ◽  
Sa’ad Y. Salim ◽  
Trevor Darby ◽  
Sven Almer ◽  
Silvia Melgar ◽  
...  
Keyword(s):  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Colonic Anastomosis ◽  
Bursting Pressure ◽  
Anti Inflammatory
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