Effects of statin and deferoxamine administration on neurological outcomes in a rat model of intracerebral hemorrhage

2011 ◽  
Vol 33 (2) ◽  
pp. 289-296 ◽  
Author(s):  
Hyoung-Joon Chun ◽  
Dong Won Kim ◽  
Hyeong-Joong Yi ◽  
Young Soo Kim ◽  
Eun Hyun Kim ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Rat Model ◽  
Neurological Outcomes

Mild therapeutic hypothermia improves neurological outcomes in a rat model of cardiac arrest

2021 ◽  
Author(s):  
Liangliang Zhang ◽  
Wei Liang ◽  
Yiling Li ◽  
Jie Yan ◽  
Jingwen Xue ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Rat Model ◽  
Mild Therapeutic Hypothermia ◽  
Neurological Outcomes

Ginsenoside Rg2 Ameliorates Brain Injury After Intracerebral Hemorrhage in a Rat Model of Preeclampsia

2021 ◽  
Author(s):  
Liying Cai ◽  
Feifei Hu ◽  
Wenwen Fu ◽  
Xiaofeng Yu ◽  
Weijie Zhong ◽  
...  
Keyword(s):  
Brain Injury ◽  
Intracerebral Hemorrhage ◽  
Rat Model

scholarly journals Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207098 ◽  
Author(s):  
Linghui Yang ◽  
Jing Wang ◽  
Yan Deng ◽  
Cansheng Gong ◽  
Qin Li ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Rat Model ◽  
Mitochondrial Function ◽  
Neurological Outcomes

Abstract P150: Sex Differences In Augmentation Index And Aortic Pulse Pressure Among Patients Diagnosed With Acute Primary Intracerebral Hemorrhage

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Fatima Ryalat ◽  
Hossam A Shaltout ◽  
Debra I DIZ ◽  
Stacey Q Wolfe
Keyword(s):  
Sex Differences ◽  
Pilot Study ◽  
Arterial Stiffness ◽  
Intracerebral Hemorrhage ◽  
Sex Difference ◽  
Augmentation Index ◽  
Institutional Research ◽  
Neurological Outcomes ◽  
Blood Pressures ◽  
Ich Score

Introduction: Intracerebral hemorrhage (ICH) is the second most common subtype of stroke. Hypertension is a major cause of primary spontaneous ICH. However, sex difference in blood pressure (BP) and arterial stiffness among ICH patients is not well characterized. Methods: A prospective pilot study to investigate the feasibility of measuring arterial stiffness in acute primary ICH patients was approved by the institutional research board at Wake Forest Baptist Health. Eligible subjects with primary ICH were enrolled in the study within 7 days of onset. Non-invasive measurements of brachial BP, aortic BP, augmentation index at heart rate of 75 beats per minute (AIx75), and carotid-femoral pulse wave velocity (cf-PWV) were measured at the patient’s bedside, using the SphygmoCor XCEL System v1 (AtCor Medical Pty Ltd., Sydney, Australia). Results: A total of 20 patients have been enrolled in the study over 5 months. Over half the patients enrolled were female (55%, n = 11), including 82% (n = 9) White, 9% (n = 1) Asian and 9% (n = 1) Hispanic. There was increased diversity in the male patients (45%, n = 9) including 44% (n = 4) Black, 22% (n = 2) White, 22% (n = 2) Hispanic, and 11% (n = 1) Asian. Men were significantly younger than women (57 ± 5 years vs 74 ± 3 years, respectively, P = 0.009). There were no significant differences in BMI or ICH score. At the time of measurement, there were no significant sex differences in brachial or aortic blood pressures (systolic and diastolic), however, females had significantly higher AIx75 (35 ± 4 vs 20 ± 6, P = 0.036) and aortic PP (53 ± 2 mm Hg vs 42 ± 4 mm Hg, P = 0.020) than males. Sex difference in cf-PWV was not statistically significant (p = 0.054). Conclusion: In the current feasibility pilot study, preliminary data show that females had higher arterial stiffness measured as AIx75 and aortic PP than males in the acute setting of ICH. Further study will be required to ascertain whether this is related to higher age at presentation in females. Whether sex differences in arterial stiffness predict differences in the outcome among ICH patients is not well characterized; thus, assessment of 30-day functional and neurological outcomes will be performed with NIHSS and modified Rankin Scores.

Does Dabigatran Increase the Risk of Delayed Hematoma Expansion in a Rat Model of Collagenase-induced Intracerebral Hemorrhage?

2015 ◽  
Vol 24 (2) ◽  
pp. 374-380 ◽  
Author(s):  
Shunsuke Tanoue ◽  
Joji Inamasu ◽  
Masayuki Yamada ◽  
Hiroshi Toyama ◽  
Yuichi Hirose
Keyword(s):  
Intracerebral Hemorrhage ◽  
Rat Model ◽  
Hematoma Expansion

Highest In-Hospital Glucose Measurements are Associated With Neurological Outcomes After Intracerebral Hemorrhage

2018 ◽  
Vol 27 (10) ◽  
pp. 2662-2668 ◽  
Author(s):  
Jonathan Rosenthal ◽  
Aaron Lord ◽  
Koto Ishida ◽  
Jose Torres ◽  
Barry M. Czeisler ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Neurological Outcomes

scholarly journals Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Gang Chen ◽  
Jingru Li ◽  
Jianjie Wang ◽  
Bihua Chen ◽  
Yongqin Li
Keyword(s):  
Cardiac Arrest ◽  
Rat Model ◽  
Animal Studies ◽  
Onset Time ◽  
Quantitative Eeg ◽  
Permutation Entropy ◽  
Sprague Dawley ◽  
Ctrl Group ◽  
Neurological Outcomes ◽  
Prognostic Accuracy

Background. Electroencephalography (EEG) is commonly used to assess the neurological prognosis of comatose patients after cardiac arrest (CA). However, the early prognostic accuracy of EEG may be affected by postresuscitation interventions. Recent animal studies found that hydrogen inhalation after CA greatly improved neurological outcomes by selectively neutralizing highly reactive oxidants, but the effect of hydrogen inhalation on EEG recovery and its prognostication value are still unclear. The present study investigated the effects of hydrogen inhalation on early postresuscitation EEG characteristics in an asphyxial CA rat model. Methods. Cardiopulmonary resuscitation was initiated after 5 min of untreated CA in 40 adult female Sprague-Dawley rats. Animals were randomized for ventilation with 98% oxygen plus 2% hydrogen (H2) or 98% oxygen plus 2% nitrogen (Ctrl) under normothermia for 1 h. EEG characteristics were continuously recorded for 4 h, and the relationships between quantitative EEG characteristics and 96 h neurological outcomes were investigated. Results. No differences in baseline and resuscitation data were observed between groups, but the survival rate was significantly higher in the H2 group than in the Ctrl group (90% vs. 40%, P<0.01). Compared to the Ctrl group, the H2 group showed a shorter burst onset time (21.85 [20.00–23.38] vs. 25.70 [22.48–30.05], P<0.01) and time to normal trace (169.83 [161.63–208.55] vs. 208.39 [186.29–248.80], P<0.01). Additionally, the burst suppression ratio (0.66 ± 0.09 vs. 0.52 ± 0.17, P<0.01) and weighted‐permutation entropy (0.47 ± 0.16 vs. 0.34 ± 0.13, P<0.01) were markedly higher in the H2 group. The areas under the receiver operating characteristic curves for the 4 EEG characteristics in predicting survival were 0.82, 0.84, 0.88, and 0.83, respectively. Conclusions. In this asphyxial CA rat model, the improved postresuscitation EEG characteristics for animals treated with hydrogen are correlated with the better 96 h neurological outcome and predicted survival.

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