Correction to: Validity of the Italian multiple sclerosis neuropsychological screening questionnaire

AbstractCognitive dysfunction, a common feature of multiple sclerosis (MS), frequently leads to impaired activities of daily living, social skills deficits, diminished social support, and unemployment. There is growing evidence indicating that cognitive impairment is amenable to the effects of medication and behavioral counseling. Unfortunately, routine neuropsychological testing is rare in MS clinics because screening is ineffective and testing strategies are often too cumbersome or expensive. Recent research supports the reliability of a brief screening test called the Multiple Sclerosis Neuropsychological Screening Questionnaire as well as a minimal neuropsychological battery called the Minimal Assessment of Cognitive Function in Multiple Sclerosis. Data indicate that the Multiple Sclerosis Neuropsychological Screening Questionnaire has excellent split-half and test-retest reliability, and that it predicts neuropsychological deficiency with good sensitivity and specificity. Recently acquired data also show that the Minimal Assessment of Cognitive Function in Multiple Sclerosis tests have good test-retest reliability, discriminate MS patients from normal controls, and predict unemployment in MS patients. Thus, these or similar methods should be employed for the routine monitoring of cognitive functioning of MS patients.

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Validation of the Multiple Sclerosis Neuropsychological Screening Questionnaire in Argentina

Multiple Sclerosis Journal ◽

10.1177/1352458508097924 ◽

2008 ◽

Vol 15 (2) ◽

pp. 244-250 ◽

Cited By ~ 15

Author(s):

S Vanotti ◽

RHB Benedict ◽

L Acion ◽

F Cáceres ◽

Keyword(s):

Multiple Sclerosis ◽

Cognitive Impairment ◽

High Risk ◽

Reliability And Validity ◽

Patient Report ◽

Screening Questionnaire ◽

Neuropsychological Screening ◽

Neuropsychological Status ◽

Report Measure ◽

Normal Controls

Backgrounds Considering the lack of screening technology that would permit neurologists to identify patients who may benefit from formal or more comprehensive assessment of neuropsychological status in patients with multiple sclerosis (MS) in Argentina, we felt the need to validate the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ) developed by Benedict, et al. Objective The objective in this multicenter study was to test the reliability and validity of the MSNQ after translation into Spanish in Argentina. We also compared the MSNQ yield by the patient report with that of the two different informants. The sample included 125 patients with MS and 36 normal controls, 27 patients had two informants available and 23 patients and their informants were examined twice at 1-week intervals (test–retest group). All participants completed the MSNQ, RAO BRB, Beck Depression Inventory-Fast Screen, EDSS, and MS Functional Composite. Results We found that an MSNQ-I score of 26 or more resulted in classifications yielding sensitivity of 0.91 and specificity of 0.80, suggesting some utility for this Argentine, informant-report measure. Conclusions This Spanish version of the MSNQ is reliable and useful as a screening test for identifying patients at high risk for cognitive impairment in MS.

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Validity of the Italian multiple sclerosis neuropsychological screening questionnaire

Neurological Sciences ◽

10.1007/s10072-021-05141-1 ◽

2021 ◽

Author(s):

Simone Migliore ◽

Doriana Landi ◽

Francesca Proietti ◽

Giulia D’Aurizio ◽

Ferdinando Squitieri ◽

...

Keyword(s):

Multiple Sclerosis ◽

Screening Questionnaire ◽

Neuropsychological Screening

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Repeated assessment of neuropsychological deficits in multiple sclerosis using the Symbol Digit Modalities Test and the MS Neuropsychological Screening Questionnaire

Multiple Sclerosis Journal ◽

10.1177/1352458508090923 ◽

2008 ◽

Vol 14 (7) ◽

pp. 940-946 ◽

Cited By ~ 121

Author(s):

RHB Benedict ◽

JA Duquin ◽

S Jurgensen ◽

RA Rudick ◽

J Feitcher ◽

...

Keyword(s):

Multiple Sclerosis ◽

Self Report ◽

Screening Tests ◽

Screening Methods ◽

Medical Patients ◽

Repeated Testing ◽

Screening Questionnaire ◽

Neuropsychological Screening ◽

Relative Contribution ◽

Independent Information

Background Brief cognitive performance tests and self-report measures of neuropsychological symptoms have been proposed for screening purposes in multiple sclerosis (MS) clinics. To better understand the reliability of screening methods, two tests, the Symbol Digit Modalities Test (SDMT) and the MS Neuropsychological Screening Questionnaire (MSNQ), were administered to 76 patients with MS and 25 healthy controls, matched on demographic characteristics. Methods Tests were administered at monthly intervals, over 6 months. In addition, the Beck Depression Inventory Fast Screen for medical patients (BDIFS) was administered to monitor for changes in depression. Our objectives were to determine the reliability of these measures and the relative contribution of cognitive impairment and depression in predicting self-report MSNQ scores. Results Results showed that both the SDMT and MSNQ have good to excellent reproducibility over repeated testing. In MS, there are minimal practice effects over successive tests, in the order of 0.2 SD for SDMT and minimal change in the MSNQ. Regression analyses modeled to predict MSNQ based on SDMT and BDIFS showed significant contribution for both, but with the majority of variance being accounted for depression. Conclusions We conclude that these brief screening tests provide some independent information about the mental status of patients with MS and are reliable, even when used in monthly, successive examinations.

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Validation and interpretation of the Dutch version of the Multiple Sclerosis Neuropsychological Screening Questionnaire

Journal of the Neurological Sciences ◽

10.1016/j.jns.2012.06.024 ◽

2012 ◽

Vol 320 (1-2) ◽

pp. 91-96 ◽

Cited By ~ 14

Author(s):

Judith M. Sonder ◽

Lidwine B. Mokkink ◽

Femke A.H. van der Linden ◽

Chris H. Polman ◽

Bernard M.J. Uitdehaag

Keyword(s):

Multiple Sclerosis ◽

Dutch Version ◽

Screening Questionnaire ◽

Neuropsychological Screening

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The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire

Multiple Sclerosis Journal ◽

10.1177/1352458518777295 ◽

2018 ◽

Vol 25 (11) ◽

pp. 1543-1546 ◽

Cited By ~ 4

Author(s):

Ilse M Nauta ◽

Lisanne J Balk ◽

Judith M Sonder ◽

Hanneke E Hulst ◽

Bernard MJ Uitdehaag ◽

...

Keyword(s):

Multiple Sclerosis ◽

Operating Characteristic ◽

Cognitively Impaired ◽

Clinical Value ◽

Screening Questionnaire ◽

Neuropsychological Screening ◽

Impaired Cognitive Function ◽

Clinical Applicability ◽

Patient Reported ◽

Cognitive Problems

Background: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS). Objective: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P). Methods: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses. Results: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition. Conclusion: Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.

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A brief neuropsychological screening test battery for cognitive dysfunction in Brazilian multiple sclerosis patients

Brain Injury ◽

10.1080/02699050801998243 ◽

2008 ◽

Vol 22 (5) ◽

pp. 419-426 ◽

Cited By ~ 10

Author(s):

Marco Aurélio Negreiros ◽

Paulo Mattos ◽

J. Landeira-Fernandez ◽

Renata Alves Paes ◽

Regina Papais Alvarenga

Keyword(s):

Multiple Sclerosis ◽

Cognitive Dysfunction ◽

Screening Test ◽

Test Battery ◽

Neuropsychological Screening ◽

Multiple Sclerosis Patients

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Validity of an Internet version of the Multiple Sclerosis Neuropsychological Questionnaire

Multiple Sclerosis Journal ◽

10.1177/1352458510379615 ◽

2010 ◽

Vol 16 (12) ◽

pp. 1500-1506 ◽

Cited By ~ 7

Author(s):

Nadine Akbar ◽

Kimia Honarmand ◽

Nancy Kou ◽

Brian Levine ◽

Neil Rector ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Impairment ◽

Sensitivity And Specificity ◽

Depression Scale ◽

Epidemiological Studies ◽

Self Report ◽

The Internet ◽

Roc Curve Analysis ◽

Internal Reliability ◽

Neuropsychological Screening

Background: Neuropsychological batteries are long and require expertise to administer. For this reason, the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) was developed as it is quick and easy to complete. The informant version of the scale has proven to be a useful screen for cognitive impairment in multiple sclerosis (MS). Objective: The objective was to validate an Internet version of the MSNQ. Methods: The following psychometric data were collected at home over the Internet in 82 MS patients: (a) patient self-report version MSNQ (P-MSNQ), (b) informant version MSNQ (I-MSNQ), and (c) Center for Epidemiological Studies Depression Scale (CES-D). Thereafter patients underwent in-office testing with the Brief Repeatable Battery of Neuropsychological Tests (BRB-N). The sensitivity and specificity of the Internet MSNQ to detect cognitive impairment relative to the BRB-N was determined using receiver operating characteristic (ROC) curve analysis. Results: Thirty-five percent of the sample was cognitively impaired. The P-MSNQ was correlated with depression and two tests of the BRB-N. The I-MSNQ was correlated with depression and all five tests of the BRB-N. A cut-off score of 26 on the I-MSNQ gave a sensitivity and specificity of 72% and 60% respectively. Test-retest and internal reliability analyses were strong for both the P-MSNQ and I-MSNQ. Conclusion: This is the first attempt at an Internet validation of the MSNQ. The modest sensitivity and specificity values suggest that further research is needed before either the patient or informant version of the MSNQ can be used for neuropsychological screening purposes over the Internet.

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