Sarcopenia in patients with dementia: correlation of temporalis muscle thickness with appendicular muscle mass

Abstract The age-associated loss of muscle mass and strength in older adults is called sarcopenia, and it is associated with increased rates of falls, fractures, hospitalizations and death. Sarcopenia is one of the most common physical etiologies for increased frailty in older adults, and some recent work has suggested the use of Point-of care ultrasound (PoCUS) measures as a potential measure of muscle mass. The objective of this study was to examine the association of PoCUS measures of muscle thickness (MT) with measures of frailty in community-dwelling older adults. We recruited 150 older adults (age >= 65; mean age 80.0±0.5 years, 66 women, 84 men) sequentially from 5 geriatric medicine clinics (Vancouver General Hospital). We measured lean muscle mass (LMM, by bioimpedance assay) and an ultrasonic measure of muscle quantity (MT, vastus medialis muscle thickness) in all subjects, as well as two outcome measures of frailty (FFI, Fried Frailty Index; RCFS, Rockwood Clinical Frailty Scale). In our models, MT showed an inverse correlation with the FFI (Standardized β=-0.2320±0.107, p=0.032) but no significant correlation with the RCFS (Standardized β = -0.025±0.086, p=0.776). LMM showed no significant association with either FFI (Standardized β=-0.232±0.120, p=0.055) or RCFS (Standardized β = -0.043±0.119, p=0.719). Our findings indicate that PoCUS measures show potential as a way to screen for physical manifestations of frailty and might be superior to other bedside methods such as bioimpedance assay. However, PoCUS measures of muscle thickness will likely miss patients showing frailty in the much broader context captured by the RCFS.

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AB0267 BODY COMPOSITION IN PATIENTS WITH RHEUMATOID ARTHRITIS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.2318 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1432.2-1432

Author(s):

N. Toroptsova ◽

O. Dobrovolskaya ◽

N. Demin ◽

L. Shornikova

Keyword(s):

Rheumatoid Arthritis ◽

Body Composition ◽

Muscle Mass ◽

Dual Energy ◽

X Ray ◽

T Score ◽

Osteosarcopenic Obesity ◽

The Mean ◽

Total Fat ◽

Appendicular Muscle Mass

Background:Rheumatoid arthritis (RA) is a complex inflammatory disease that modifies body composition. Using the dual-energy x-ray absorptiometry (DXA) in RA patients could be a method for body composition changes detection.Objectives:To study the body composition using DXA in patients with RA.Methods:The study involved 79 women with RA, median age 60 [55; 65] years. The bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry using «Discovery A» (Hologic, USA). Assessment of body composition was carried out, using the program «Whole body». Sarcopenia (SP) was diagnosed as a decrease in appendicular mass index (AMI) <6.0 kg/m2. Osteoporosis (OP) was diagnosed as a decrease in T-score <-2.5 SD. Osteosarcopenia was determined when T-score was <-1.0 SD, AMI was <6.0 kg/m2, osteosarcopenic obesity - T-score was <-1.0 SD, AMI was <6.0 kg/m2and total fat was >35%.Results:The mean duration of RA was 9 [3; 11] years. The mean body mass index (BMI) was 27.6±4.8 kg/m2. Disease activity score in 28 joints-erythrocyte sedimentation rate was 4.5±1.3 points for the group. 39 (49.3%) patients used oral glucocorticoids continuously. Appendicular muscle mass and AMI were on average 17.8±3.0 kg and 6.8±1.0 kg/m2, respectively. AMI <6 kg/m2was detected in 20 (25.3%) patients. 56 (70.9%) women with RA had total fat > 35%, while only 22 (27.8%) of women with RA had obesity according to BMI (BMI >30 kg/m2). Isolated OP was found in 13 (16.5%), osteosarcopenia in 7 (8.9%) and osteosarcopenic obesity in 13 (16.5%) patients RA. No cases with isolated sarcopenia or sarcopenic obesity were detected. Only 3 (3.8%) patients did not have appendicular muscle mass, AMI and BMD decrease and overfat or obesity.Conclusion:About 97% women with RA had abnormal body composition phenotype: 16,5% - OP, 8.9% -osteosarcopenia, 16,5% - osteosarcopenic obesity and 54,4% - overfat.Disclosure of Interests:None declared

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Relationship between trunk muscle strength and trunk muscle mass and thickness using bioelectrical impedance analysis and ultrasound imaging

Bio-Medical Materials and Engineering ◽

10.3233/bme-211218 ◽

2021 ◽

pp. 1-10

Author(s):

Ryo Miyachi ◽

Nana Koike ◽

Suzu Kodama ◽

Junya Miyazaki

Keyword(s):

Muscle Strength ◽

Muscle Mass ◽

Ultrasound Imaging ◽

Bioelectrical Impedance Analysis ◽

Muscle Thickness ◽

Bioelectrical Impedance ◽

Impedance Analysis ◽

Trunk Muscle ◽

Trunk Muscles ◽

Trunk Muscle Strength

BACKGROUND: Although trunk muscles are involved in many important functions, evaluating trunk muscle strength is not an easy task. If trunk muscle mass and thickness could be used as indicators of trunk muscle strength, the burden of measurement would be reduced, but the relationship between trunk muscle strength and trunk muscle mass and thickness has not been clarified. OBJECTIVE: The purpose of this study was to clarify the relationship between trunk muscle strength and trunk muscle mass by bioelectrical impedance analysis and trunk muscle thickness by ultrasound imaging in healthy adults. METHODS: One hundred and twenty-one healthy university students were included in this study. Trunk flexion/extension muscle strength and trunk muscle mass by bioelectrical impedance analysis, and trunk muscle thickness by ultrasound imaging were measured. RESULTS: Both trunk flexion strength and trunk extension strength were significantly correlated with trunk muscle mass and oblique and rectus abdominis muscle thickness. Multiple regression analysis showed that trunk extension muscle strength had an independent relationship with trunk muscle mass. CONCLUSIONS: This study demonstrated that trunk muscle mass or trunk muscle thickness can be used as an alternative means for evaluating trunk muscle strength, making the evaluation of trunk muscles less burdensome.

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ESTIMATION OF APPENDICULAR MUSCLE MASS IN HOSPITALIZED OLDER ADULTS USING BIOELECTRICAL IMPEDANCE

Innovation in Aging ◽

10.1093/geroni/igx004.455 ◽

2017 ◽

Vol 1 (suppl_1) ◽

pp. 109-109

Author(s):

R.R. Deer ◽

L. Akhverdiyeva ◽

E. Volpi

Keyword(s):

Older Adults ◽

Muscle Mass ◽

Bioelectrical Impedance ◽

Hospitalized Older Adults ◽

Appendicular Muscle Mass

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Relationship between Masseter Muscle Thickness and Skeletal Muscle Mass in Elderly Persons Requiring Nursing Care in North East Japan

International Journal of Oral-Medical Sciences ◽

10.5466/ijoms.15.152 ◽

2017 ◽

Vol 15 (3-4) ◽

pp. 152-159 ◽

Cited By ~ 3

Author(s):

Kento Umeki ◽

Yutaka Watanabe ◽

Hirohiko Hirano

Keyword(s):

Skeletal Muscle ◽

Muscle Mass ◽

Nursing Care ◽

Masseter Muscle ◽

Skeletal Muscle Mass ◽

Muscle Thickness ◽

Elderly Persons ◽

North East

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Simple Estimation of Appendicular Muscle Mass using the Maximum Calf Circumference of Elderly Inpatients

Rigakuryoho Kagaku ◽

10.1589/rika.31.511 ◽

2016 ◽

Vol 31 (4) ◽

pp. 511-515 ◽

Cited By ~ 1

Author(s):

Tadashi ITO ◽

Yoshihito SAKAI ◽

Yoshifumi MORITA ◽

Makoto OIKAWA ◽

Kazuya GOTO ◽

...

Keyword(s):

Muscle Mass ◽

Calf Circumference ◽

Elderly Inpatients ◽

Simple Estimation ◽

Appendicular Muscle Mass

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Simplified morphological evaluation of skeletal muscle mass and maximum muscle strength in healthy young women: Comparison between thigh and calf

Women s Health ◽

10.1177/1745506520962009 ◽

2020 ◽

Vol 16 ◽

pp. 174550652096200

Author(s):

Tomohiro Yasuda

Keyword(s):

Skeletal Muscle ◽

Regression Analysis ◽

Muscle Mass ◽

Young Women ◽

Skeletal Muscle Mass ◽

Handgrip Strength ◽

Muscle Thickness ◽

Skeletal Muscle Index ◽

Stand Test ◽

Sit To Stand

Objectives: The purpose of this study was to examine the prediction of skeletal muscle mass and maximum muscle strength using simplified morphology evaluation in young Japanese women from the thigh and calf perspective. Methods: A total of 249 Japanese young women (aged 18–25 years) were used for data analyses in this study. Thigh and calf girths were measured using a tape measure at 50% of thigh length and at 30% proximal of calf length, respectively. Muscle thickness was measured using B-mode ultrasound at the anterior and posterior thigh (at 50% of thigh length) and at the posterior lower leg (at 30% proximal of calf length), respectively. The measurements were carried out on the right side of the body while the participants stood with their elbows extended and relaxed. A stepwise multiple regression analysis (method of increasing and decreasing the variables; criterion set at p < 0.05) was performed for skeletal muscle index (defined by appendicular skeletal muscle mass/height2), handgrip strength, or sit-to-stand test and five variable factors (girth (thigh and calf) and muscle thickness (anterior and posterior thigh and posterior calf)). Results: Unlike the sit-to-stand test, skeletal muscle index or handgrip strength was correlated ( p < 0.001) with the girth or muscle thickness for both thigh and calf. Unlike the sit-to-stand test, the prediction equations for skeletal muscle index and handgrip strength estimation showed significant correlations with multiple regression analysis of data obtained from the calf girth and muscle thickness. In both skeletal muscle index and handgrip strength, calf girth was adopted as a Step 1, respectively. Conclusion: Our results indicated that skeletal muscle index and handgrip strength could be evaluated by the simplified morphology methods, especially that for the calf girth measurement, which may be a good indicator of screening/preventing for sarcopenia in healthy Japanese young women.

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ROUNDS Studies: Relation of OUtcomes with Nutrition Despite Severity—Round One: Ultrasound Muscle Measurements in Critically Ill Adult Patients

Journal of Nutrition and Metabolism ◽

10.1155/2018/7142325 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Carlos Alfredo Galindo Martín ◽

Reyna del Carmen Ubeda Zelaya ◽

Enrique Monares Zepeda ◽

Octavio Augusto Lescas Méndez

Keyword(s):

Intensive Care Unit ◽

Logistic Regression ◽

Intensive Care ◽

Muscle Mass ◽

Sofa Score ◽

Protective Factor ◽

Severity Of Illness ◽

Muscle Thickness ◽

Rectus Femoris ◽

Adult Patients

Malnutrition (undernutrition) encompasses low intake or uptake, loss of fat mass, and muscle wasting and is associated with worse outcomes. Ultrasound has been introduced in the intensive care unit as a tool to assess muscle mass. The aim of the present study is to explore the relation between initial muscle mass and mortality in adult patients admitted to the intensive care unit. Methods. Rectus femoris and vastus intermedius thicknesses were measured by B-mode ultrasound in adult patients at admission, along with demographic characteristics, illness severity, comorbidities, biochemical variables, treatments, and in-hospital mortality as main outcomes. Analysis was made comparing survivors versus nonsurvivors and finally using binary logistic regression with mortality as dependent variable. Results. 59 patients were included in the analysis, severity measured by sequential organ failure assessment (SOFA) score was greater in nonsurvivors (17 (7) versus 24 (10) and 3 (1–5) versus 7 (3–10), resp.). Also, muscle thickness was lower in the latter group (1.44 (0.59) cm versus 0.98 (0.3) cm). Logistic regression showed severity by SOFA score as a risk factor and muscle thickness as a protective factor for mortality. Conclusion. Muscle mass showed to be a protective factor despite severity of illness; there is much more work to do regarding interventions and monitoring in order to prevent or overcome low muscle mass at admission to the intensive care unit.

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