Polymorphisms in host genes encoding NOSII, C-reactive protein, and adhesion molecules thrombospondin and E-selectin are risk factors for Plasmodium falciparum malaria in India

2015 ◽  
Vol 34 (10) ◽  
pp. 2029-2039 ◽  
Author(s):  
K. Kanchan ◽  
◽  
S. S. Pati ◽  
S. Mohanty ◽  
S. K. Mishra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasmodium Falciparum ◽  
Adhesion Molecules ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Genes Encoding ◽  
Host Genes

Determination of PCT on admission is a useful tool for the assessment of disease severity in travelers with imported Plasmodium falciparum malaria

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Elda Righi ◽  
Maria Merelli ◽  
Alessandra Arzese ◽  
Paola Della Siega ◽  
Claudio Scarparo ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Disease Severity ◽  
Plasmodium Falciparum Malaria ◽  
C Reactive Protein ◽  
Reactive Protein

AbstractProcalcitonin (PCT) and C-reactive protein (CRP) may be useful to predict complicated forms of malaria. A total of 30 consecutive travelers diagnosed with

Imported Plasmodium falciparum malaria in Istanbul, Turkey: risk factors for severe course and mortality

2013 ◽  
Vol 43 (4) ◽  
pp. 129-133 ◽  
Author(s):  
Ferhat Arslan ◽  
Ali Mert ◽  
Ayse Batirel ◽  
Asuman Inan ◽  
Ilker Inanc Balkan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria

scholarly journals Epidemiology of Plasmodium falciparum Malaria and Risk Factors for Severe Disease in Hubei Province, China

2020 ◽  
Vol 103 (4) ◽  
pp. 1534-1539
Author(s):  
Jing Xia ◽  
Dongni Wu ◽  
Kai Wu ◽  
Hong Zhu ◽  
Lingcong Sun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Severe Disease ◽  
Plasmodium Falciparum Malaria ◽  
Hubei Province

scholarly journals Fibrinogen and C-Reactive Protein Significance in Children Infected by Plasmodium falciparum Species in Enugu, Enugu State, Nigeria

2021 ◽  
pp. 1-8
Author(s):  
Linda Nnenna Ogbonna ◽  
Silas Anayo Ufelle ◽  
Emmanuel Ifeanyi Obeagu ◽  
Pat Uzo Okpala ◽  
Bessie N. Esimai ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Parasite Density ◽  
Health Centre ◽  
Blood Film ◽  
University Teaching ◽  
Morbidity Rate ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Enugu State

Malaria accounts for a considerable mortality and morbidity rate with children bearing the greatest burden. The study investigated fibrinogen and C-reactive protein (CRP) value alterations in children infected by Plasmodium falciparum (P. falciparum) species. A case control study with a total of ninety-five microscopically confirmed P. falciparum malaria infected children and fifty apparently healthy age and gender matched controls from Enugu State University Teaching Hospital, Parklane, Wesley Specialist Hospital and Akpugo Community Health Centre, Enugu were recruited for the study. Fibrinogen level was determined by clauss clotting time method using sodium citrated plasma. Giemsa stained thick and thin blood film was used for parasite identification and calculation of parasite density. Serum CRP values was determined by immunoturbidimetric method. Fibrinogen levels were significantly increased (p < 0.05) in P. falciparum infected children (324.03 + 59.87) mg/dl as compared to the control (224.74 + 34.88) mg/dl. Parasite density showed a weak positive correlation between fibrinogen (p < 0.01, r = 0.461) and CRP (p < 0.01, r = 0.232). CRP was significantly increased (p < 0.05) in P. falciparum malaria infected children (21.52 + 35.59) mg/l as compared to the control (2.43 + 0.97) mg/l. In conclusion, P. falciparum malaria infection demonstrated a significant impact on fibrinogen and CRP.

Risk factors of chloroquine resistance in Plasmodium falciparum malaria

Acta Tropica ◽  
1996 ◽  
Vol 61 (4) ◽  
pp. 293-306 ◽  
Author(s):  
Folke I. Hess ◽  
Aniello Iannuzzi ◽  
Judson Leafasia ◽  
David Cowdrey ◽  
Hans D. Nothdurft ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Chloroquine Resistance

scholarly journals Rapid diagnostic test negative Plasmodium falciparum malaria in a traveller returning from Ethiopia

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Stefan Schlabe ◽  
Ingrid Reiter-Owona ◽  
Tamara Nordmann ◽  
Ramona Dolscheid-Pommerich ◽  
Egbert Tannich ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
False Negative ◽  
Plasmodium Falciparum Malaria ◽  
Negative Results ◽  
First Case ◽  
False Negative Results ◽  
Genes Encoding ◽  
Life Threatening ◽  
And Control

Abstract Background Plasmodium falciparum strains with mutations/deletions of the genes encoding the histidine-rich proteins 2/3 (pfhrp2/3) have emerged during the last 10 years leading to false-negative results in HRP2-based rapid diagnostic tests (RDTs). This can lead to unrecognized infections in individuals and to setbacks in malaria control in endemic countries where RDTs are the backbone of malaria diagnostics and control. Case description Here the detection of a pfhrp2/3-negative P. falciparum infection acquired in Ethiopia by a 63-year old female traveller is presented. After onset of symptoms during travel, she was first tested negative for malaria, most probably by RDT, at a local hospital in Harar, Ethiopia. Falciparum malaria was finally diagnosed microscopically upon her return to Germany, over 4 weeks after infection. At a parasite density of approximately 5387 parasites/µl, two different high-quality RDTs: Palutop + 4 OPTIMA, NADALRMalaria PF/pan Ag 4 Species, did not respond at their respective P. falciparum test lines. pfhrp2/3 deletion was confirmed by multiplex-PCR. The patient recovered after a complete course of atovaquone and proguanil. According to the travel route, malaria was acquired most likely in the Awash region, Central Ethiopia. This is the first case of imported P. falciparum with confirmed pfhrp2/3 deletion from Ethiopia. Conclusion HRP2-negative P. falciparum strains may not be recognized by the presently available HRP2-based RDTs. When malaria is suspected, confirmation by microscopy and/or qPCR is necessary in order to detect falciparum malaria, which requires immediate treatment. This case of imported P. falciparum, non-reactive to HRP2-based RDT, possibly underlines the necessity for standardized, nationwide investigations in Ethiopia and should alert clinicians from non-endemic countries to the possibility of false-negative RDT results which may increase in returning travellers with potentially life-threatening infections.

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